Patents Assigned to Chiron
  • Carrier for tool holders
    Patent number: 7255667
    Abstract: A carrier for tool holders of a machine tool has at least one movable jaw which can be pivoted about a pivot axis that runs transversely with respect to a longitudinal axis of said tool holders. Said movable jaw can be pivoted between an expanded position and a closed position in which it grasps in a form-fitting manner a tool holder which is inserted into said carrier.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: August 14, 2007
    Assignee: Chiron-Werke GmbH & Co. KG
    Inventors: Dirk Prust, Hans-Henning Winkler
  • Streptococcus pneumoniae knockout mutants
    Publication number: 20070184443
    Abstract: 91 genes have been identified in Streptococcus pneumoniae that, when knocked out, result in a lethal phenotype. A further 10 genes have been identified that, when knocked out, result in poor growth characteristics when cultured in the absence of blood. These 101 genes are essential to bacterial growth and are thus useful antibiotic targets. Their invention includes knockout mutants for these 101 genes and screening methods involving the protein products of the 101 genes.
    Type: Application
    Filed: August 9, 2004
    Publication date: August 9, 2007
    Applicant: CHIRON SRL
    Inventor: Antonello Covacci
  • Pyrrole based inhibitors of glycogen synthase kinase 3
    Patent number: 7250443
    Abstract: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: July 31, 2007
    Assignee: Chiron Corporation
    Inventors: Manoj C. Desai, Simon Ng, Zhi-Jie Ni, Keith B. Pfister, Savithri Ramurthy, Sharadha Subramanian, Allan S. Wagman
  • Human cyclin-dependent kinase ()
    Patent number: 7250256
    Abstract: A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: July 31, 2007
    Assignee: Chiron Corporation
    Inventor: Christoph Reinhard
  • Truncated keratinocyte growth factor (KGF) having increased biological activity
    Patent number: 7247452
    Abstract: The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: July 24, 2007
    Assignee: Chiron Corporation
    Inventors: Denis J. Gospodarowicz, Frank R. Masiarz
  • Immunisation against Chlamydia pneumoniae
    Publication number: 20070116726
    Abstract: The published genomic sequence of Chlamydia pneumoniae reveals over 1000 putative encoded proteins but does not itself indicate which of these might be useful antigens for immunisation and vaccination or for diagnosis. This difficulty is addressed by the invention, which provides a number of C. pneumoniae protein sequences suitable for vaccine production and development and/or for diagnostic purposes.
    Type: Application
    Filed: May 1, 2006
    Publication date: May 24, 2007
    Applicant: Chiron S.r.I.
    Inventors: Guilio Ratti, Guido Grandi
  • Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process
    Publication number: 20070117131
    Abstract: Novel processes for the replication of influenza viruses in cell culture, and vaccines and diagnostic compositions which contain the influenza viruses obtainable by the process or constituents thereof, are described.
    Type: Application
    Filed: November 3, 2006
    Publication date: May 24, 2007
    Applicant: CHIRON BEHRING GMBH & CO.
    Inventor: Albrecht Groner
  • Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia
    Publication number: 20070110754
    Abstract: Methods of therapy for treating a subject for chronic lymphocytic leukemia are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CN40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing chronic lymphocytic leukemia cells.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 17, 2007
    Applicant: Chiron Corporation
    Inventors: Li Long, Mohammad Luqman, Asha Yabannavar, Isabet Zaror, Sharon Aukerman
  • Methods of therapy for b cell-related cancers
    Publication number: 20070098718
    Abstract: Methods of treating a human subject for a cancer characterized by neoplastic B cell growth are provided. The methods comprise administering combination antibody therapy to the subject, where an effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof in combination with an anti-CD20 antibody or antigenbinding fragment thereof is administered to the subject. The invention further comprises pharmaceutical compositions with combinations of these antibodies in a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 3, 2007
    Applicant: Chiron
    Inventors: Li Long, Mohammad Luqman, Asha Yabannavar, Isabel Zaror
  • Methods of therapy for solid tumors expressing the cd40 cell-surface antigen
    Publication number: 20070098717
    Abstract: Methods of therapy are provided for treating a subject for a solid tumor that comprises carcinoma cells expressing the CD40 cell-surface antigen. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a subject in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Binding of the anti-CD4 antibody or suitable antigen-binding fragment thereof beneficially inhibits growth of solid tumors via ADCC-dependent killing of the CD40-expressing carcinoma cells.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 3, 2007
    Applicant: Chiron Corporation
    Inventors: Li Long, Mohammad Lugman, Asha Yabannavar, Isabel Zaror
  • Machine tool
    Patent number: 7211033
    Abstract: A machine tool has at least one working spindle, in which a tool receptacle for tool holders is provided. Furthermore, there is a tool-changing arm with a gripper, for a tool holder in order to transfer this tool holder between its magazine position, which is spaced apart from the tool receptacle, and its working position, in which the tool holder can be clamped into the tool receptacle. Orientation means are provided between the gripper and the tool holder supported by it and secure the tool holder in a nonrotatable manner on the gripper at least during its transfer between the magazine position and the working position and release it after it has been clamped into the tool receptacle, with the result that the tool holder can be rotated in relation to the gripper.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: May 1, 2007
    Assignee: Chiron-Werke GmbH & Co. KG
    Inventors: Dirk Prust, Rudolf Haninger, Hans-Henning Winkler
  • Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
    Patent number: 7211659
    Abstract: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: May 1, 2007
    Assignee: Chiron Corporation
    Inventors: Jan zur Megede, Susan Barnett
  • Injectable vaccines against multiple meningococcal serogroups
    Publication number: 20070082014
    Abstract: An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said capsular saccharides are conjugated to carrier protein(s) and/or are oligosaccharides, and wherein (i) the composition comprises <50 ?g meningococcal saccharide per dose, and/or (ii) the composition further comprises an antigen from one or more of: (a) serogroup B N. meningitidis; (b) Haemophilus influenzae type B; and/or (c) Streptococcus pneumoniae. Saccharide antigens in the compositions are generally conjugated to a carrier.
    Type: Application
    Filed: January 30, 2004
    Publication date: April 12, 2007
    Applicant: CHIRON SRL
    Inventor: Paolo Costantino
  • Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers
    Patent number: 7198899
    Abstract: This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies capable of specifically binding to NRG4.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: April 3, 2007
    Assignee: Chiron Corporation
    Inventors: Siew C. Schleyer, Anne B. Jefferson, Judith A. Abraham, W. Michael Kavanaugh
  • GSK3 polypeptides
    Patent number: 7195886
    Abstract: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3? and GSK3? polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: March 27, 2007
    Assignee: Chiron Corporation
    Inventors: Stephen D Harrison, John A Hall, Maria Calderon-Cacia, Ziyang Zhong, Eric Y Fang, Doris G Coit, Steve H Nguyen, Angelica Medina-Selby
  • Immunogenic compositions for streptococcus pyogenes
    Publication number: 20070065464
    Abstract: The invention includes a GAS antigen, GAS 40, which is particularly suitable for use either alone or in combinations with additional GAS antigens, such as GAS 117, GAS 130, GAS 277, GAS 236, GAS 40, GAS 389, GAS 504, GAS 509, GAS 366, GAS 159, GAS 217, GAS 309, GAS 372, GAS 039, GAS 042, GAS 058, GAS 290, GAS 511, GAS 533, GAS 527, GAS 294, GAS 253, GAS 529, GAS 045, GAS 095, GAS 193, GAS 137, GAS 084, GAS 384, GAS 202, and GAS 057.
    Type: Application
    Filed: July 30, 2004
    Publication date: March 22, 2007
    Applicant: CHIRON CORPORATION
    Inventors: Guido Grandi, John Telford, Giuliano Bensi
  • Methods for purifying authentic IGF from yeast hosts
    Patent number: 7193042
    Abstract: Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 20, 2007
    Assignees: Chiron Corporation, Cephalon, Inc.
    Inventors: Cynthia Cowgill, Luis Juarbe-Osorio, Patricio Riquelme, Glenn Dorin, Christopher M. Bussineau, Robert D. Kudrna, Carl Scandella, Russell A. Brierley, Joan N. Abrams, John M. Hanson, Francis C. Maslanka
  • Guanidino compounds
    Patent number: 7189727
    Abstract: Compounds having the general structure III are provided: where D is N or C; W is selected from Z1, Z2, and Z3 are independently selected from CR8 and N; and the other variables have the values described herein. Compounds of formula III have useful properties for controlling diseases related to MC4-R action in humans including obesity and type II diabetes.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: March 13, 2007
    Assignee: Chiron Corporation
    Inventors: Rustum Boyce, David Duhl
  • Protein associated with cell stress response
    Patent number: 7186530
    Abstract: A stress-phosphorylated endoplasmic reticulum protein, Nogo B, is provided. The protein is hyperphosphorylated as a result of exposure of cells to stress. Two transcripts of Nogo B are identified in human tissues, and the longer transcript is predominant in human brain tumor samples.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 6, 2007
    Assignee: Chiron Corporation
    Inventors: Dong Wei, Robert F. Halenbeck, Lewis T. Williams
  • Estrogen receptor modulators
    Patent number: RE39708
    Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: June 26, 2007
    Assignee: Chiron Corporation
    Inventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj C. Desai, Beata Krywult, Rajinder Singh, Liang Wang