Patents Assigned to Chiroscience Limited
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Patent number: 7012135Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF?. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF?.Type: GrantFiled: June 6, 2001Date of Patent: March 14, 2006Assignee: Celltech Chiroscience LimitedInventors: Diljeet Singh Athwal, Derek Thomas Brown, Andrew Neil Charles Weir, Andrew George Popplewell, Andrew Paul Chapman, David John King
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Patent number: 6242464Abstract: Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O,O′-diaroyltartaric acid as resolving agent.Type: GrantFiled: January 22, 1997Date of Patent: June 5, 2001Assignee: Chiroscience LimitedInventors: Michael Christopher James Harris, Hooshang Zavareh
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Patent number: 5891878Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumour Necrosis Factor activity. The compounds of the invention have the general formula (I): ##STR1## The compounds of the invention encompassed by formula (I) include enantiomers, diastereoisomers and mixtures, including racemic mixtures.Type: GrantFiled: August 2, 1996Date of Patent: April 6, 1999Assignee: Chiroscience LimitedInventors: Steven Colin Beasley, John Gary Montana, Hazel John Dyke, Alan Findlay Haughan, Karen Ann Runcie, David Thomas Manallack, George Martin Buckley, Robert James Maxey, Hannah Jayne Kendall, Andrew Douglas Baxter
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Patent number: 5872146Abstract: Described herein are compounds of formula (I): ##STR1## which have MMP and TNF inhibitory activity.Type: GrantFiled: April 4, 1997Date of Patent: February 16, 1999Assignee: Chiroscience LimitedInventors: Andrew Douglas Baxter, John Gary Montana, David Alan Owen
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Patent number: 5853623Abstract: The present invention concerns novel mercaptoalkylpeptidyl compounds of formula (I) which are useful inhibitors of matrix metalloproteinase and/or TNF-mediated diseases including degenerative diseases and certain cancers. The invention also concerns methods of treating patients suffering from disorders or diseases which can be attributed to or are associated with matrix metalloproteinase or TNF activity.Type: GrantFiled: May 10, 1996Date of Patent: December 29, 1998Assignee: Chiroscience LimitedInventors: John Montana, David Alan Owen, Jonathan Dickens, Andrew Douglas Baxter
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Patent number: 5840923Abstract: An optically-purified enantiomer of the lactone 4-hydroxy-2-oxabicyclo-?3.3.0!oct-7-en-3-one or an acylate thereof can be obtained by biotransformation. It is a useful synthon in the preparation of an enantiomer of 3-hydroxymethyl-2-hydroxycyclopentene that can be used to prepare carbocyclic nucleosides as a desired enantiomer.Type: GrantFiled: October 21, 1994Date of Patent: November 24, 1998Assignee: Chiroscience LimitedInventors: Stanley Michael Roberts, Horacio F. Olivo, Raymond McCague
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Patent number: 5834485Abstract: The subject invention pertains to quinolinesulfonamides. The subject compounds can be used to treat disease states, such as those that are associated with proteins that mediate cellular activity, for example, by inhibiting phosphodiesterase IV (PDE IV) or tumor necrosis factor (TNF). The invention also pertains to methods of treating disease states, including those states capable of being modulated by inhibition of PDE IV or TNF.Type: GrantFiled: May 20, 1997Date of Patent: November 10, 1998Assignee: Chiroscience LimitedInventors: Hazel Joan Dyke, John Gary Montana
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Patent number: 5821366Abstract: 1,3-Disubstituted-zanthines have therapeutic utility via TNF or phosphodiesterase inhibition.Type: GrantFiled: May 20, 1996Date of Patent: October 13, 1998Assignee: Chiroscience LimitedInventor: John Gary Montana
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Patent number: 5821369Abstract: A process for the racemization of an enantiomerically-enriched compound of formula (3), comprises treatment of enantiomerically-enriched (3) with a base to obtain anion (4), optionally in protonated form, which is then combined with CH.sub.2 =CH--Y.sup.1 to form racemic (3), ##STR1## wherein Ar=aryl or heteroaryl; Ak=C.sub.1-20 alkyl; X=CN, CO.sub.2 R, CONR.sup.1 R.sup.2, and COR; Y and Y.sup.1 are independently selected from CN, CO.sub.2 R, CONR.sup.1 R.sup.2 and R, R.sub.1 and R.sub.2 are independently selected from H and C.sub.1-20 alkyl; optionally as a salt thereof.This racemization process can be used as part of an efficient synthesis of enantiomerically-enriched verapamil or aminoglutethimide.Type: GrantFiled: February 7, 1997Date of Patent: October 13, 1998Assignee: Chiroscience LimitedInventor: Raymond McCague
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Patent number: 5811558Abstract: The subject invention pertains to a process for the resolution of etodolac comprising the use of the resolving agent glucamine or a N-(C.sub.1-4 alkyl)-glucamine. The subject invention also concerns a process for converting a single enantiomer of etodolac into the racemate. The method comprises forming all ester of the carboxylate function of the enantiomer and treating with an acid or base.Type: GrantFiled: December 6, 1996Date of Patent: September 22, 1998Assignee: Chiroscience LimitedInventors: Brian Michael Adger, Ulrich Conrad Dyer, Martin Woods, John Francis Paul Andrews, Helen Frances Baker
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Patent number: 5804588Abstract: The subject invention concerns novel compounds of the general formula (i) ##STR1## that are useful in treating disease states, such as those states associated with proteins that mediate cellular activity. The compounds of the subject invention can be used, for example, to inhibit tumor necrosis factor and/or phosphodiesterase IV, The subject invention also concerns methods for treating disease states using the compounds of the invention.Type: GrantFiled: May 20, 1997Date of Patent: September 8, 1998Assignee: Chiroscience LimitedInventors: Hazel Joan Dyke, John Gary Montana, Christopher Lowe, Hannah Jayne Kendall, Verity Margaret Sabin
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Patent number: 5792774Abstract: A compound of formula (I) ##STR1## or a pharmaceutically-acceptable salt, solvate or hydrate thereof.Type: GrantFiled: February 21, 1997Date of Patent: August 11, 1998Assignee: Chiroscience LimitedInventors: Alan Findlay Haughan, Steven Colin Beasley, John Gary Montana, Robert John Watson
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Patent number: 5786484Abstract: A process for the racemisation of an optically-enriched piperidine-2-carboxanilide compound, comprises heating the compound in the presence of an alkanoic or arylalkanoic acid. A process for the asymmetric transformation of such a compound comprises heating the compound in the presence of an acid as defined above, a chiral acid resolving agent and an inert cosolvent.Type: GrantFiled: May 30, 1997Date of Patent: July 28, 1998Assignee: Chiroscience LimitedInventors: Ulrich Conrad Dyer, Christopher James Lock, Martin Woods
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Patent number: 5777124Abstract: A process for preparing levobupivacaine, racemic bupivacaine or another N-alkyl analogue thereof, comprises chlorinating pipecolic acid hydrochloride, amidation of the resultant pipecolyl chloride hydrochloride in solvent, without isolation, with 2,6-dimethylaniline, and alkylation of the resultant pipecolic acid 2,6-xylidide. Alternatively, the alkylation may be followed by the amidation.Type: GrantFiled: April 25, 1997Date of Patent: July 7, 1998Assignee: Chiroscience LimitedInventors: Hooshang Shahriari Zavareh, Graham Anthony Charles Frampton
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Patent number: 5753666Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumor Necrosis Factor activity.Type: GrantFiled: August 2, 1996Date of Patent: May 19, 1998Assignee: Chiroscience LimitedInventors: Steven Colin Beasley, John Gary Montana, Hazel Joan Dyke, Alan Findlay Haughan, George Martin Buckley, Andrew Douglas Baxter
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Patent number: 5739332Abstract: A process for the product of a 2,3-cis-dihydroxycycloalkane-1-carboxamide, comprises dihydroxylation of the corresponding cycloalkene-1-carboxamide. Some products are new. The stereoselective dihydroxylation is surprising.Type: GrantFiled: June 4, 1996Date of Patent: April 14, 1998Assignee: Chiroscience LimitedInventors: Raymond McCague, Graham Ruecroft, Christopher Palmer
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Patent number: 5736549Abstract: Compounds of formula I ##STR1## where n=0-2;R.sup.1 is H, NH.sub.2 or a halogen;R.sup.2 is H or NH.sub.2 ;R.sup.3 is any of the four groups ##STR2## where m=0 or 1; andX is O, NR.sup.5, or S(O).sub.0-2 and, in group (b), the X's may be the same or different.Compounds of the invention have utility as inhibitors of purine nucleoside phosphyorylase (PNP).Type: GrantFiled: October 5, 1995Date of Patent: April 7, 1998Assignee: Chiroscience LimitedInventors: Steven Colin Beasley, Alan Findlay Haughan, John Montana, Robert John Watson
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Patent number: 5733754Abstract: An enzyme is provided which has acylase activity capable of hydrolyzing N-acetyl-(R,S)-pipecolic acid stereoselectively to give (S)-pipecolic acid, wherein this activity is greater than that on N-acetyl-S-proline, at pH 7.5, 25.degree. C., and substrate concentration 20 g/l, in 75 mM Tris buffer. The enzyme is obtainable from the species of Alcaligenes denitrificans deposited as NCIMB 40587. A microorganism having therein the enzyme also is provided, as is a process for preparing (S)-pipecolic acid comprising contacting a mixture of enantiomers of an N-acyl-pipe colic acid with the enzyme or microorganism.Type: GrantFiled: April 8, 1996Date of Patent: March 31, 1998Assignee: Chiroscience LimitedInventors: Richard Anthony Wisdom, Caroline Susan Lee, Paul Maurice Ricaud
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Patent number: 5728712Abstract: 3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.Type: GrantFiled: May 20, 1996Date of Patent: March 17, 1998Assignee: Chiroscience LimitedInventors: John Gary Montana, Hazel Joan Dyke, Robert James Maxey, Christopher Lowe
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Patent number: 5714351Abstract: The individual enantiomers of the compounds (Ia), (Ib), (IIa) or (IIb), optionally substituted by non-interfering substituent(s). The novel enantiomers can be obtained by biotransformation. The (Ia) or (IIa) compounds can be used for the synthesis of chiral carbocyclic nucleosides.Type: GrantFiled: February 13, 1995Date of Patent: February 3, 1998Assignee: Chiroscience LimitedInventors: Christopher Thomas Evans, Stanley Michael Roberts, Karoline Shoberu, Rosemary Mackeith