Abstract: Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O, O′-diaroyltartaric acid as resolving agent.
Type:
Grant
Filed:
April 17, 2001
Date of Patent:
March 11, 2003
Assignee:
Chiroscience, Ltd.
Inventors:
Michael Christopher James Harris, Hooshang Zavareh
Abstract: Benzofuran carboxides and sulphonamides have therapeutic utility, e.g. in the treatment of inflammation and asthma, by virtue of their ability to inhibit phosphodiesterases and tumor necrosis factor.
Type:
Grant
Filed:
December 5, 1996
Date of Patent:
June 30, 1998
Assignee:
Chiroscience, Ltd.
Inventors:
Hazel Joan Dyke, Hannah Jayne Kendall, Christopher Lowe, John Gary Montana
Abstract: Lactams of 1-amino-3-carboxylic acid cyclic compounds are provided in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferably 2-azabicyclo?2.2.1!hept-5-en-3-one.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
November 18, 1997
Assignee:
Chiroscience, Ltd.
Inventors:
Christopher Thomas Evans, Stanley Micahel Roberts
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