Patents Assigned to Chondrogene Limited
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Patent number: 7432049Abstract: The invention provides for nucleic acid sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild osteoarthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these nucleic acid sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the nucleic acids of the invention or alter the anabolic level of a chondrocyte.Type: GrantFiled: February 28, 2002Date of Patent: October 7, 2008Assignee: Chondrogene LimitedInventors: Choong-Chin Liew, Wayne Marshall, Hongwei Zhang
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Publication number: 20040265868Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 30, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040265869Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 30, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040248170Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 9, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040248169Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 9, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040241729Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 2, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040241726Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 2, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040241728Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 2, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040241727Abstract: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-specific genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen.Type: ApplicationFiled: March 30, 2004Publication date: December 2, 2004Applicant: ChondroGene LimitedInventor: Choong-Chin Liew
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Publication number: 20040209275Abstract: The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.Type: ApplicationFiled: September 12, 2003Publication date: October 21, 2004Applicant: Chondrogene LimitedInventors: Choong-Chin Liew, K. Wayne Marshall, Hongwei Zhang
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Publication number: 20040127445Abstract: The invention relates to the discovery of the role of beta-2 microglobulin (B2M) in the pathogenesis of osteoarthritis (OA) and the ability of B2M to inhibit chondrocyte proliferation. The invention further relates to the identification of genes regulated by B2M (the “B2M related genes”).Type: ApplicationFiled: August 26, 2003Publication date: July 1, 2004Applicant: Chondrogene LimitedInventors: Choong-Chin Liew, K. Wayne Marshall, Hongwei Zhang