Abstract: This invention discloses a single-needle medication mixer, dual hard ports, and a soft intravenous bag, pertaining to the field of medical apparatus technologies. The medication mixer comprises a base, a medication mixing passage, a medication mixing cup, and a piercing needle. The base, the medication mixing passage and the medication mixing cup are integrally formed, the medication mixing cup consists of cup wall and cup bottom, the lower end of the medication mixing passage penetrates through the base, and the upper end penetrates through the cup bottom; the upper end of the medication mixing passage is provided with the piercing needle having a hollow passage, the lower end of the piercing needle is connected to the upper end of the medication mixing passage in a sealing way, and the hollow passage is communicated therewith. The medication mixer of this invention is convenient to use and has no potential safety hazard.

Abstract: This invention discloses a medication mixer, dual hard dual ports, and a soft intravenous bag. The medication mixer comprises a base, a medication mixing passage, a medication mixing cup, and a cross needle which are integrally formed. The medication mixing cup consists of a cup wall and a cup bottom. The cross needle consists of an integrated needle plate, and an upper needle and lower needle with hollow passages which are communicated with each other. The lower end of the medication mixing passage penetrates through the base, with the upper ends penetrating through the cup bottom. A membrane is arranged in the medication mixing passage between the base and the cup bottom, and a rubber plug is arranged in the medication mixing passage between the membrane and the cup bottom. A limit protrusion is arranged on an inner wall of the cup wall.

Abstract: The present invention discloses an assembly machine for a medicine mixer, comprising a rack, a medicine mixing cup mounting device, a rubber plug mounting device, an elastic clip mounting device, a puncture needle mounting device, a coverplate mounting device, a soldering device and an output device. The medicine mixing cup mounting device, the rubber plug mounting device, the elastic clip mounting device, the puncture needle mounting device, the coverplate mounting device, the soldering device and the output device are arranged annularly along an outer circumference of the dividing table successively. The assembly machine for a medicine mixer according to the present invention is controlled by PLC. A feeding system consisting of a plurality of groups of oscillating disks and tracks conveys each part at an interface of the medicine mixer to given positions of the equipment.

Abstract: A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7).

Abstract: An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.

Abstract: A double-headed transfusion container comprises a body portion (1), both the top and the bottom of the body portion (1) being provided with an opening portion (2). The body portion (1) and the opening portion (2) are integrally formed of polypropylene blending plastic through blow molding, so as to obtain a seamless transparent polypropylene blending plastic transfusion container, which has advantages of a light weight and a low cost, further has good self-draining performance, and can steadily drain the liquid in the container from the container without any vent needle. Both the top and the bottom of the body portion (1) are provided with the opening portion (2), which facilitates connection to another independent auxiliary instrument better and can improve the safety of the transfusion product.

Abstract: An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.

Abstract: A preassembled medicine mixer comprises a rotary sleeve (4), a guide sleeve I (3), a guide sleeve II (6), a guide part, a dosing barrel (1), and a dosing double needle (2). The guide sleeve I (3) extends into the guide sleeve II (6) and is connected to the rotary sleeve (4). A guide groove (8) is provided on the side wall of the guide sleeve I (3), and two ends of the guide groove (8) are extended by a distance towards opposite directions. A guide spiral groove (7) is provided on an inner wall of the guide sleeve II (6). The guide part is disposed in the guide sleeve I (3) and has a guide block (9) at the outer side thereof. The guide block (9) penetrates through the guide groove (8) and extends into the guide spiral groove (7).

Abstract: A doser having two needles. The two needles consist of a needle seat (1), an upper needle (2), and a lower needle (3). The upper needle (2) and the lower needle (3) are arranged at two sides of the needle seat (1), and the upper needle (2) and the lower needle (3) both have a hollow structure and are in communication with each other. A medicine mixing body (4) of a cup structure is formed through extension in the direction along the edge of the needle seat (1) toward the upper needle (2). When the doser having two needle is used, it is only required that the upper needle (1) penetrates through a sealing plug of a medicine container and the lower needle (3) simultaneously penetrates through a sealing plug inside a sealing cover on a transfusion container, and by squeezing the transfusion container, medicine in the medicine container can be mixed with a solution in the transfusion container, which makes the medicine mixing operation simpler and more time saving.

Abstract: The invention belongs to the pharmaceutical field, and particularly relates to a lyophilized formulation of pectin-adriamycin conjugate and a preparation method thereof. In order to solve insolubility problem of the pectin-adriamycin conjugate (hereinafter referred to as PAC), improve bioavailability and facilitate preparation, the inventor prepared the PAC into a nanosuspension. However, as long-term stability of the nanosuspension is poor, the inventor proposed to prepare the nanosuspension into a lyophilized formulation, that is, an insoluble pectin-adriamycin conjugate is prepared into a suspension or nanosuspension, and a lyophilized support agent is added to the suspension for lyophilization treatment to prepare the lyophilized formulation. Lyophilized products prepared from the nanosuspension are characterized by enhanced stability of nano-particle size and enhanced stability of drug loading rate, which provides a new solution for clinical application of the PAC.

Abstract: The invention relates to a passive solid tumor-targeted anticancer prodrug and a preparation method thereof, belonging to the field of antitumor drugs. The preparation method includes the following steps: reacting low molecular weight pectin with Mw of 5,000-45,000 with doxorubicin to obtain a pectin-doxorubicin conjugate with Mw of 100,000-1,000,000, preparing the conjugate into a suspension, and treating the suspension in an ultra-high pressure nano homogenizer to obtain the passive solid tumor-targeted anticancer prodrug with particle size of 100 nm-200 nm and melting point of 220-245°, wherein the pectin and doxorubicin are linked by an amide bond, and the pectin is linked by an ester bond formed by condensing carboxyl groups and hydroxyl groups of pectin molecules. Cell inhibition rate of the anticancer prodrug for humanized lung cancer cells NCI-H446 and A549 is equivalent to that of doxorubicin hydrochloride.