Patents Assigned to Chongqing Runze Pharmaceutical Co., Ltd
  • Patent number: 10913923
    Abstract: The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: February 9, 2021
    Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
    Inventor: Lei Ye
  • Patent number: 10835641
    Abstract: A porous material and preparation method thereof is provided. The material includes a material body. The body consists of pore cavities classified according to pore size of material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities framed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing raw powders with pore-forming agent for the smallest-level pore cavities of porous material to formulate slurry; uniformly filling the slurry into polymer material support to form green body and get dried and smashed to obtain mixed grains; uniformly mixing the mixed grains with pore-forming agent for upper-level pore cavities greater than the smallest-level pore cavities of porous material to make compact green body; performing vacuum sintering; performing the conventional follow-up treatment according to the raw materials process of porous material.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 17, 2020
    Assignee: CHONGQING RUNZE PHARMACEUTICALS CO., LTD.
    Inventor: Lei Ye
  • Patent number: 10597755
    Abstract: The present invention relates to a porous material, wherein the pores of the porous material are uniformly distributed. The uniform distribution of the pores means that the pores are evenly distributed at any unit-level volume of the porous material. The elastic modulus of the porous material is reduced by 10-99% compared to that of the raw material used to make the porous material. This kind of porous material ensures the uniformity of its various properties. It is a porous material with excellent performance and quality. Its uniformity also ensures that its elastic modulus can be effectively reduced to meet multiple purposes.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: March 24, 2020
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20190024031
    Abstract: The present invention provides a culture device for tissue cell, and the culture device for tissue cell includes a tissue cell culture body. The porous material of the tissue cell culture body is composed by pore cavities which are classified according to the material pore size and cavity walls which are formed around the pore cavity at all levels. And the lower level small pore cavities are provided on the cavity wall formed around the upper level large pore cavities. The pore cavities within the same level are in communication with each other. And the pore cavities at all levels are also be in communication with each other. This device is particularly benefit for cell culture, so that tissue cells can freely and normally grow in three-dimensional space.
    Type: Application
    Filed: August 9, 2016
    Publication date: January 24, 2019
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20190024032
    Abstract: The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space.
    Type: Application
    Filed: August 9, 2016
    Publication date: January 24, 2019
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20180305791
    Abstract: The present invention relates to a porous material, the pores of the porous material are uniformly distributed. The uniform distribution of the pores means that the pores are evenly distributed at any unit-level volume of the porous material. The elastic modulus of the porous material is reduced by 10-99% compared to that of the raw material used to make the porous material. This kind of porous material ensures the uniformity of its various properties. It is a porous material with excellent performance and quality. Its uniformity also ensures that its elastic modulus can be effectively reduced to meet multiple purposes.
    Type: Application
    Filed: August 15, 2016
    Publication date: October 25, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20180243093
    Abstract: The present invention relates to a new application of a porous material. The porous material is composed of pore cavities and cavity walls surrounding the pore cavities, wherein the pore cavities of the porous material are three-dimensionally interconnected; the capillary force of the porous material is 5 Pa or more; and a contact angle between a surface of the cavity wall of the porous material and a liquid phase material circulating therein is less than 90°. The porous material is applied as a microcirculation power source. The porous material is used in a circulation system as a microcirculation power source for providing material exchange. The porous material is used in a separation system as a microcirculation power source for providing material separation and movement. The porous material is used in a medical implant system as a microcirculation power source for providing tissue cell growth.
    Type: Application
    Filed: September 8, 2016
    Publication date: August 30, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20180236137
    Abstract: A hierarchical porous material consists of multistage porous materials, comprising a material body, the body is formed bar a pore cavity graded according to the pore size of the material and a cavity wall surrounding to form the pore cavity. The pore cavities are uniformly distributed. The characteristics are as follows. A lower-level pore cavities are disposed on the cavity wall of an upper-level pore cavity formed by surrounding a three-dimensional space. Each level of pore cavities are mutually connected and the pore cavities within same level are also connected with each other. The uniform distribution of the pore cavities means that similar amount of pore cavities are distributed under any unit volume of the hierarchical porous material. The hierarchical structure of the cavity of the material enables it to meet a wide range of functional requirements.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20180237733
    Abstract: The present invention relates to a culture device for tissue cell suspension. The culture device includes a tissue cell culture body. The tissue cell culture body is a porous material. The porous material is formed by cavities classified into different levels according to the pore size of material and cavity walls surrounding to form the cavities. A lower level of small cavities is provided to surround the cavity wall which forms the upper level of large cavity. Cavities of each level are in communication with each other, and cavities between respective levels are also in communication with each other. The culture device further includes a swirler device provided therein. Such culture device can particularly facilitate normal and unrestricted growth of the suspension of cells in three-dimensional space, obstructing the formation of over-dense cell region or nutrient-rich region during the cell culturing.
    Type: Application
    Filed: August 9, 2016
    Publication date: August 23, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Publication number: 20180237888
    Abstract: A multilevel porous metal material, where the levels are classified based on the pore size of the material. The number of classified levels are at least more than two. The pore size of the smallest level of porous metal material is less than 1 micrometer. The elasticity modulus of the smallest level of porous metal material is less than 80 GPa. The porosity is no less than 48%. The preparation method thereof is as follows. The raw material powder used to prepare porous metal material and the pore-forming agent used to prepare the smallest level of pores cavities are mixed to prepare the slurry. The slurry is uniformly filled into polymer material support to form a green body. The green body is dried and crushed to obtain mixed grains.
    Type: Application
    Filed: August 16, 2016
    Publication date: August 23, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei YE
  • Publication number: 20180236138
    Abstract: A porous material and preparation method thereof is provided. The material includes a material body. The body consists of pore cavities classified according to pore size of material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities framed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing raw powders with pore-forming agent for the smallest-level pore cavities of porous material to formulate slurry; uniformly filling the slurry into polymer material support to form green body and get dried and smashed to obtain mixed grains; uniformly mixing the mixed grains with pore-forming agent for upper-level pore cavities greater than the smallest-level pore cavities of porous material to make compact green body; performing vacuum sintering; performing the conventional follow-up treatment according to the raw materials process of porous material.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Applicant: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Patent number: 9440918
    Abstract: A method for purifying (S)-oxiracetam is disclosed. Crude (S)-oxiracetam with the purity of 89% is dissolved in water; the solution is allowed to stand for 1 to 3 days at 0° C. to 18° C.; a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water to 0° C. to 5° C.; and the product is dried in vacuum to obtain high-purity (S)-oxiracetam.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: September 13, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventors: Lei Ye, Zuyuan Rong
  • Patent number: 9427268
    Abstract: A porous tantalum rod is provided, which is a medical implantation used for treating collapsed articular surface of the femoral head or necrosis of the femoral head in phase I or phase II. The implantation includes a fastening structure formed on one end of the porous tantalum rod used for connecting with the osseous tissues and a through hole formed on the center of the porous tantalum rod. The porous tantalum rod is made of the porous tantalum material, which is produced by foam impregnation and had a foam structure with three-dimensional interconnecting pores, wherein the foam structure has a foam skeleton, tantalum particles located on the foam skeleton, and multiple sintering neck structures formed between the tantalum particles.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: August 30, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventor: Lei Ye
  • Patent number: 9295475
    Abstract: A drill bit locking device and a drill bit are provided. The locking device includes a boss with a through hole, a bearing and a support member are arranged an inner wall of a small cylinder above the boss; a locking sleeve is sleeved over the boss, a first bulge is on an inner wall of an upper part of the locking sleeve, and a second bulge is on an inner wall of a lower part; a spring is between the second bulge and an upper bottom surface of the boss; a press plate is threadedly connected with an outer wall of a top part of the small cylinder and presses against the first bulge; holes of different sizes are on the inner wall of the small cylinder and the support member to form a stepped hole, and a steel ball is arranged in the stepped hole.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: March 29, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventors: Lei Ye, Jian Zhou, Hua Feng, Fei Li, Hengyang Zhu, Congxiao Li
  • Patent number: 9295480
    Abstract: A craniotomy drill includes a main machine, a retarder and a locking seat. A drill transmission rod connected to the output shaft of the retarder is inserted in the locking seat. The main machine comprises a handle at the lower portion and an accommodating part at the upper portion, with a stator and a rotor of a DC electric motor being provided inside the accommodating part and a wall of the accommodating part being the stator housing of the DC electric motor. This craniotomy drill has a simple structure with the wall of the accommodating part as the stator housing of the electric motor, such that the volume and the weight are reduced. It is safe in use without the risk of the electric motor sliding out. By utilizing materials and processes of water resistant technology and an integrative design, a relatively good water resistant performance is achieved.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: March 29, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventors: Lei Ye, Jian Zhou, Hua Feng, Fei Li, Hengyang Zhu, Congxiao Li
  • Patent number: 9282982
    Abstract: A surgical milling cutter bracket includes a retaining base having a through hole. The upper part of the retaining base is provided with a finger guide having an L-shaped support frame on the top of the finger guide. A downward protrusion is provided at the end of the short side of the L-shaped support frame. The lowest point of the protrusion is lower than the lowest point of the cylindrical head of the milling cutter during normal operation of the milling cutter. A bolt having a through hole at the center is fixed within the cavity of the finger guide. A depressor is provided on the upper part of the retaining base. The bolt passes through a hole of the depressor and is connected to a nut. The protrusion is able to prevent an object from contacting the cylindrical head, thus avoiding cutting the object unevenly.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: March 15, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventors: Lei Ye, Jian Zhou, Hua Feng, Fei Li, Hengyang Zhu, Congxiao Li
  • Patent number: 9254136
    Abstract: A drill head locking apparatus and a drill head are provided. The locking apparatus includes a protruding platform having a through hole, a bearing on the inner wall of a small cylinder on the protruding platform, a locking sleeve fitted on the protruding platform, and a protrusion arranged on the upper part of the inner wall of the locking sleeve. The lower part of the inner wall of the locking sleeve is a conical face. A spring is arranged between the bottom face of the conical face and an upper bottom face of the protruding platform. A press plate is connected with a screw thread on the outer wall of the top part of the small cylinder on the protruding platform and presses down on the protrusion. A conical hole is arranged on the wall of the small cylinder and communicates with the through hole of the protruding platform.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: February 9, 2016
    Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
    Inventors: Lei Ye, Jian Zhou, Hua Feng, Fei Li, Hengyang Zhu, Congxiao Li
  • Patent number: 9238622
    Abstract: A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: January 19, 2016
    Assignee: CHONGQING RUNZE PHARMACEUTICAL CO., LTD.
    Inventors: Chao You, Hua Feng, Qi Pang, Lei Ye, Yuying Chen, Zuyuan Rong, Lei Jin, Nan Xu, Fei Li, Bo Li
  • Patent number: 9126928
    Abstract: Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: September 8, 2015
    Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
    Inventor: Lei Ye
  • Patent number: 9126929
    Abstract: An (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide racemate referred to as (S)-oxiracetam crystal form II has a diffraction peak at a diffraction angle 2? of 10.669, 13.25, 13.847, 14.198, 16.729, 17.934, 18.746, 18.816, 20.273, 20.413, 21.431, 21.617, 21.663, 23.38, 24.324, 24.415, 26.069, 26.107, 27.901, 28.621, 28.925, 29.449, 29.484, 31.702, 36.516, 37.685, or 39.721 degrees. The purity of the (S)-oxiracetam crystal form II can be up to 98.5%, and the (S)-oxiracetam crystal form II has the advantages of simple preparation method, mild control condition, low production cost, and the produced oxiracetam hydrate crystal form II has a high purity (the oxiracetam hydrate crystal form having a purity of 8%˜98.5% can be prepared by a crude levo-oxiracetam having a purity of 92%, and thus having a good reproducibility in production.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: September 8, 2015
    Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
    Inventor: Lei Ye