Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
July 23, 2019
Assignees:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., CHONGQING ZEIN PHARMACEUTICAL CO., LTD
Inventors:
Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
Type:
Grant
Filed:
February 18, 2015
Date of Patent:
January 16, 2018
Assignees:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., CHONGQING ZEIN PHARMACEUTICAL CO., LTD
Inventors:
Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.
Type:
Grant
Filed:
January 22, 2014
Date of Patent:
July 11, 2017
Assignees:
H. Lee Moffitt Cancer Center and Research Institute, Inc., Chongqing Zein Pharmaceutical Co., Ltd.
Inventors:
Yong Qin, Chunwei Cheng, Hao Song, Rongshi Li, Yan Liu