Abstract: The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid.
Type:
Application
Filed:
May 26, 2008
Publication date:
February 24, 2011
Applicants:
CHONGQING ZHIEN PHARMACEUTICAL CO., LTD., SICHUAN UNIVERSITY
Inventors:
Yong Qin, Xianglin Deng, Xuan Zhou, Guofeng Yu, Ke Wang, Hao Song, Xiaolin Wang, Shan Huang