Patents Assigned to CHONNAM NATIONAL UNIVERSITY HOSPITAL
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Patent number: 11690727Abstract: The present disclosure relates to an artificial ankle joint tibial component and, more particularly, to an artificial ankle joint tibial component of an implant that is implanted into a body, the implant including: a body part having a contact surface in contact with a resected surface of a distal end of a tibia of a joint and a joint surface facing a joint; and a fixing part formed to extend a predetermined length upwards from the contact surface, wherein the fixing part is configured as a single body formed to extent a predetermined length upwards from the center in the front area of the contact surface and includes a wing extending to one side, and wherein the wing includes at least one posterior wing that extends at a predetermined angle relative to an AP line, thereby preventing stress from being concentrated on one wing to avoid a fracture thereof and increasing the contact area between a bone and an implant to strengthen fixing force, prevent rotation, and disperse stress, so that bone resorption arounType: GrantFiled: August 28, 2018Date of Patent: July 4, 2023Assignees: CORENTEC CO., LTD., CHONNAM NATIONAL UNIVERSITY HOSPITAL, INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITYInventors: Keun-Bae Lee, Tae-Jin Shin
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Patent number: 11033598Abstract: A method for preventing or treating hearing loss includes administering a composition comprising an oat extract to a subject. The method may use avenanthramide or a derivative thereof an oat extract. The oat extract has an effect on hair cells of the cochlea, spinal ganglion cells, and angiocytes, and an effect of inhibiting occurrence of hearing loss and can be usefully used for preventing or treating hearing loss. In particular, since the oat extract is a natural product and has stability without cytotoxicity, the composition containing the oat extract as an active ingredient has a safety advantage for long-term use without side effects on the human body.Type: GrantFiled: September 17, 2018Date of Patent: June 15, 2021Assignees: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY, CHONNAM NATIONAL UNIVERSITY HOSPITAL, REPUBLIC OF KOREA (MANAGEMENT : RURAL DEVELOPMENT ADMINISTRATION)Inventors: Hyong Ho Cho, Hyung Seok Kim, Sung Su Lee, Yu Young Lee
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Publication number: 20210170076Abstract: A tacrolimus drug-eluting stent manufacturing method according to the present invention enables a tacrolimus drug to be strongly and stably bound onto a stent, while also not necessarily involving a separate step of introducing a surface-binding functional group for the binding of a drug onto a stent and a step of introducing, into the drug, a functional group capable of binding to the surface-binding functional group, and a tacrolimus drug-eluting stent manufactured by the manufacturing method has a greater total drug elution amount and has a more excellent delayed drug-elution property.Type: ApplicationFiled: December 19, 2018Publication date: June 10, 2021Applicants: Industry Foundation of Chonnam National University, Chonnam National University HospitalInventors: Myung Ho JEONG, Dae Sung PARK, In-Ho BAE, Kyung Seob LIM, Jae Won SHIM, So Youn LEE, Eun Jae JANG, Doo Sun SIM, In Soo KIM, Jun Kyu PARK
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Patent number: 10343184Abstract: Provided is a drug-eluting coronary stent. In the drug-eluting coronary stent according to the present invention, electrospinning is used, thereby making it possible to precisely control a total content of an everolimus-based drug bound thereto and form a uniform layer in spite of not using a polymer causing late thrombosis, or the like.Type: GrantFiled: September 26, 2017Date of Patent: July 9, 2019Assignee: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Dae Sung Park, In-Ho Bae, Jae Won Shim, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Jun Kyu Park, In Soo Kim, Doo Sun Sim, Myung Ho Jeong
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Patent number: 10299697Abstract: The present disclosure relates to a microelectrode for measuring EMG signals of a laboratory microfauna. The present disclosure includes a metal plate with an insulating plate deposited on a surface, a plurality of silicon substrates disposed on the insulating plate, the silicon substrates being electrically connected to the metal plate, covered with an insulator, and adjacent to one another, and a plurality of needle electrodes, each formed on the respective silicon substrates as an integral part thereof, wherein the needle electrodes have the same predetermined length, have a tapered shape from the respective silicon substrates, are spaced apart from each other by a predetermined distance, and wherein a metallic layer is formed on each of the needle electrodes by depositing metal materials, the insulator is formed on the metallic layer, and a portion of the metallic layer at a tip is exposed.Type: GrantFiled: November 3, 2015Date of Patent: May 28, 2019Assignees: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY, CHONNAM NATIONAL UNIVERSITY HOSPITAL, DAEGU GYEONGBUK INSTITUTE OF SCIENCE & TECHNOLOGYInventors: Sung-Joon Cho, Seok-Yong Choi, Tai-Seung Nam, Dong-Hak Byun, So-Hee Kim, Myeong-Kyu Kim
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Patent number: 10232091Abstract: Provided are a stent in which a surface of a stent strut is treated by femtosecond laser radiation and is modified by a natural polymer and a method of preparing the stent. The stent and the preparing method may inhibit restenosis and stimulate reendothelialization.Type: GrantFiled: December 27, 2016Date of Patent: March 19, 2019Assignees: CHONNAM NATIONAL UNIVERSITY HOSPITAL, JEONNAM TECHNOPARKInventors: In Ho Bae, Dae Sung Park, So Youn Lee, Eun Jae Jang, Jae Won Shim, Kyung Seob Lim, Jun Kyu Park, Kwang Hwan Oh, Myung Ho Jeong
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Patent number: 10221227Abstract: A peptide has the amino acid sequence of SEQ ID NO: 1. The peptide exhibits the activity of a differentiation factor by promoting differentiation by acting on osteoblasts or vascular endothelial cells. Additionally, the peptide can be used for ameliorating or treating the diseases or conditions of effectiveness of osteogenic differentiation factor or bone morphogenetic factor or vascularization factor.Type: GrantFiled: April 25, 2016Date of Patent: March 5, 2019Assignees: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY, CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Taek Rim Yoon, Hyung Keun Kim, Jong Keun Seon, Ji Hyun Kim, Ju Yeon Kang
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Patent number: 9974889Abstract: The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.Type: GrantFiled: December 5, 2016Date of Patent: May 22, 2018Assignee: Chonnam National University HospitalInventors: Jin Sook Kwon, Young Keun Ahn, Myung Ho Jeong, Sun Jung Song, Dong Lyun Cho
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Patent number: 9795987Abstract: Provided is a drug-eluting coronary stent. In the drug-eluting coronary stent according to the present invention, electrospinning is used, thereby making it possible to precisely control a total content of an everolimus-based drug bound thereto and form a uniform layer in spite of not using a polymer causing late thrombosis, or the like.Type: GrantFiled: August 29, 2016Date of Patent: October 24, 2017Assignee: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Dae Sung Park, In-Ho Bae, Jae Won Shim, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Jun Kyu Park, In Soo Kim, Doo Sun Sim, Myung Ho Jeong
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Patent number: 9757356Abstract: A pharmaceutical composition and a method for preventing or treating a cardiovascular disease are provided. The pharmaceutical composition includes a BIO compound ((2?Z,3?E)-6-bromoindirubin-3?-oxime) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition can specifically act on different types of cells constituting heart tissues, that is, can induce the growth of cardiomyocytes, and can also inhibit proliferation of cardiac fibroblasts and strongly suppress inflammatory mediators in macrophages, thereby significantly recovering the tissues and functions of the heart after the onset of myocardial infarction. Therefore, the pharmaceutical composition can be effectively used to treat various cardiovascular diseases including myocardial infarction.Type: GrantFiled: July 29, 2016Date of Patent: September 12, 2017Assignee: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Youngkeun Ahn, Yong Sook Kim, Hye-yun Jeong, Darren R. Williams, Da-Woon Jung
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Publication number: 20170100372Abstract: A pharmaceutical composition and a method for preventing or treating a cardiovascular disease are provided. The pharmaceutical composition includes a BIO compound ((2?Z,3?E)-6-bromoindirubin-3?-oxime) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition can specifically act on different types of cells constituting heart tissues, that is, can induce the growth of cardiomyocytes, and can also inhibit proliferation of cardiac fibroblasts and strongly suppress inflammatory mediators in macrophages, thereby significantly recovering the tissues and functions of the heart after the onset of myocardial infarction. Therefore, the pharmaceutical composition can be effectively used to treat various cardiovascular diseases including myocardial infarction.Type: ApplicationFiled: July 29, 2016Publication date: April 13, 2017Applicant: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Youngkeun AHN, Yong Sook KIM, Hye-yun JEONG, Darren R. WILLIAMS, Da-Woon JUNG
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Patent number: 9603892Abstract: Provided are a peptide compound prepared by additional synthesis in a drug having an effect of inhibiting restenosis, a composition for inhibiting restenosis and promoting re-endothelialization including the peptide compound, and a stent having a surface coated by using the composition, in order to overcome a restenosis problem in the stent.Type: GrantFiled: April 27, 2016Date of Patent: March 28, 2017Assignee: Chonnam National University HospitalInventors: In-Ho Bae, Dae Sung Park, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Myung Ho Jeong
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Patent number: 9603893Abstract: Provided are a peptide compound prepared by additional synthesis in a drug having an effect of inhibiting restenosis, a composition for inhibiting restenosis and promoting re-endothelialization including the peptide compound, and a stent having a surface coated by using the composition, in order to overcome a restenosis problem in the stent.Type: GrantFiled: April 27, 2016Date of Patent: March 28, 2017Assignee: Chonnam National University HospitalInventors: In-Ho Bae, Dae Sung Park, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Myung Ho Jeong
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Patent number: 9603891Abstract: Provided are a peptide compound prepared by additional synthesis in a drug having an effect of inhibiting restenosis, a composition for inhibiting restenosis and promoting re-endothelialization including the peptide compound, and a stent having a surface coated by using the composition, in order to overcome a restenosis problem in the stent.Type: GrantFiled: June 17, 2015Date of Patent: March 28, 2017Assignee: Chonnam National University HospitalInventors: In-Ho Bae, Dae Sung Park, So Youn Lee, Eun Jae Jang, Kyung Seob Lim, Myung Ho Jeong
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Patent number: 9545400Abstract: Disclosed is an analgesic composition including an opioid analgesic and a therapeutically effective amount of P7C3, and the present analgesic composition may treat acute and facilitated pain very effectively, and has a significantly high synergistic effect compared to the effect by administration of individual drugs.Type: GrantFiled: July 29, 2014Date of Patent: January 17, 2017Assignee: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Myung Ha Yoon, Sang Wan Ryu
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Patent number: 9533074Abstract: The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.Type: GrantFiled: December 2, 2011Date of Patent: January 3, 2017Assignee: Chonnam National University HospitalInventors: Jin Sook Kwon, Young Keun Ahn, Myung Ho Jeong, Sun Jung Song, Dong Lyun Cho
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Patent number: 9238055Abstract: Disclosed are a peptide for promoting osteogenesis and vascularization, and the use thereof. The peptide has a low molecular weight so that it can be economically produced. In addition, it promotes osteoblastic differentiation, thus inducing osteogenesis. Further, the peptide can promote the expression of VEGF, resulting in vascularization. Accordingly, the peptide is useful for the delay of the onset of ischemic diseases and the therapy of ischemic diseases.Type: GrantFiled: January 13, 2014Date of Patent: January 19, 2016Assignee: Chonnam National University HospitalInventors: Taek Rim Yoon, Hyung Keun Kim, Ji Hyun Kim, Myung Ho Jeong
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Publication number: 20140200174Abstract: Disclosed are a peptide for promoting osteogenesis and vascularization, and the use thereof. The peptide has a low molecular weight so that it can be economically produced. In addition, it promotes osteoblastic differentiation, thus inducing osteogenesis. Further, the peptide can promote the expression of VEGF, resulting in vascularization. Accordingly, the peptide is useful for the delay of the onset of ischemic diseases and the therapy of ischemic diseases.Type: ApplicationFiled: January 13, 2014Publication date: July 17, 2014Applicant: Chonnam National University HospitalInventors: Taek Rim YOON, Hyung Keun KIM, Ji Hyun KIM, Myung Ho JEONG
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Publication number: 20140018908Abstract: The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.Type: ApplicationFiled: December 2, 2011Publication date: January 16, 2014Applicant: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Jin Sook Kwon, Young Keun Ahn, Myung Ho Jeong, Sun Jung Song, Dong Lyun Cho
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Publication number: 20120309675Abstract: Disclosed are a peptide for promoting osteogenesis and vascularization, and the use thereof. The peptide has a low molecular weight so that it can be economically produced. In addition, it promotes osteoblastic differentiation, thus inducing osteogenesis. Further, the peptide can promote the expression of VEGF, resulting in vascularization. Accordingly, the peptide is useful for the prophylaxis or therapy of ischemic diseases.Type: ApplicationFiled: June 1, 2012Publication date: December 6, 2012Applicant: CHONNAM NATIONAL UNIVERSITY HOSPITALInventors: Taek Rim YOON, Hyung Keun KIM, Ji Hyun KIM