Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
Type:
Application
Filed:
August 24, 2023
Publication date:
December 7, 2023
Applicants:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: This disclosure relates to a process for producing Crystalline Beta Nicotinamide Riboside Triacetate Chloride with improved physical property characteristics. A substantially crystalline Beta Nicotinamide Riboside Triacetate Chloride, or a salt, or a solvate thereof is described having a chemical purity of greater than about 90% (w/w) and containing less than about 5000 ppm ethanol.
Type:
Application
Filed:
March 15, 2023
Publication date:
September 21, 2023
Applicant:
ChromaDex Inc.
Inventors:
Aron Erickson, Philip Redpath, Jacob Roodman, Richard Nygaard
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Grant
Filed:
June 22, 2020
Date of Patent:
September 5, 2023
Assignees:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: Infant formula compositions and methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.
Type:
Application
Filed:
November 30, 2022
Publication date:
June 29, 2023
Applicant:
ChromaDex Inc.
Inventors:
Ryan Dellinger, Troy Rhonemus, Mark Morris, Dietrich Conze, Amy Boileau
Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
December 13, 2022
Assignee:
ChromaDex Inc.
Inventors:
Ryan Dellinger, Troy Rhonemus, Mark Morris, Dietrich Conze, Amy Boileau
Abstract: A process is provided for microencapsulating nicotinamide riboside (NR), and other NR derivatives by using ethyl cellulose which may be polymerized in a particular manner. Further, compositions comprising NR or derivatives thereof microencapsulated in an edible biopolymer are provided.
Type:
Application
Filed:
January 31, 2022
Publication date:
August 4, 2022
Applicant:
ChromaDex Inc.
Inventors:
Aron Erickson, Amanda Storjohann, Joshua Holloway, Philip Redpath
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Grant
Filed:
December 15, 2021
Date of Patent:
May 31, 2022
Assignees:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Application
Filed:
December 15, 2021
Publication date:
April 7, 2022
Applicants:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Grant
Filed:
April 30, 2021
Date of Patent:
March 15, 2022
Assignees:
ChromaDex Inc., The Queen's University of Belfast
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.
Type:
Grant
Filed:
May 18, 2021
Date of Patent:
February 8, 2022
Assignees:
ChromaDex Inc., The Queen's University of Belfast
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: The present disclosure provides crystalline Form II of nicotinic acid riboside, crystalline Form II of nicotinic acid riboside triacetate, and methods of preparation thereof.
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Application
Filed:
April 30, 2021
Publication date:
November 25, 2021
Applicants:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Application
Filed:
June 22, 2020
Publication date:
November 11, 2021
Applicants:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.
Type:
Application
Filed:
December 8, 2020
Publication date:
July 29, 2021
Applicant:
ChromaDex Inc.
Inventors:
Ryan Dellinger, Troy Rhonemus, Mark Morris, Dietrich Conze, Amy Boileau
Abstract: Compositions containing nicotinamide riboside (NR) are provided. NR containing compositions are used in the care or treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing nicotinamide riboside. In further embodiments, the invention relates to methods of using nicotinamide riboside to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival. A method of treating signs or symptoms of aging or skin wrinkles in an individual is provided, comprising topically administering to the individual in need of such treatment an effective amount of the compound nicotinamide riboside, or salts thereof.
Abstract: The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.
Type:
Grant
Filed:
May 11, 2018
Date of Patent:
March 2, 2021
Assignees:
ChromaDex Inc., The Queen's University of Belfast
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Ryan Dellinger, Troy Rhonemus, Sylesh Venkataraman, Brian Nettles
Abstract: Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
December 8, 2020
Assignee:
ChromaDex, Inc.
Inventors:
Ryan Dellinger, Troy Rhonemus, Mark Morris, Dietrich Conze, Amy Boileau
Abstract: Compositions containing nicotinamide riboside (NR) are provided. NR containing compositions are used in the care or treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing nicotinamide riboside. In further embodiments, the invention relates to methods of using nicotinamide riboside to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival. A method of treating signs or symptoms of aging or skin wrinkles in an individual is provided, comprising topically administering to the individual in need of such treatment an effective amount of the compound nicotinamide riboside, or salts thereof.
Abstract: Methods for stabilizing or encapsulating at least one compound selected from the group consisting of nicotinamide riboside (NR), nicotinic acid riboside (NAR), nicotinamide mononucleotide (NMN), nicotinic acid mononucleotide (NaMN), derivatives thereof, or salts thereof, are provided. Compositions including wax prills, stabilized, or encapsulated forms of at least one compound selected from the group consisting of nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, are also provided.
Type:
Application
Filed:
February 21, 2020
Publication date:
August 27, 2020
Applicant:
ChromaDex Inc.
Inventors:
Aron Erickson, Amanda Storjohann, Philip Redpath, Matthew Roberts
Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
Type:
Grant
Filed:
November 10, 2017
Date of Patent:
June 23, 2020
Assignees:
The Queen's University of Belfast, ChromaDex Inc.
Inventors:
Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann