Abstract: Some embodiments of the invention provide a system comprising a meter and a disposable cartridge for analyzing a fluid sample typically blood that is drawn into the cartridge by capillary action, negative pressure, positive pressure, or a combination thereof. The cartridge has at least one flow path, and includes at least one optical chamber for spectroscopic measurement, and at least one biosensor for biosensor measurement. The meter has a sample slot for receiving the disposable cartridge. The cartridges have electrical output contacts, and the meter slot has electrical input contacts. When the output contacts mate with the input contacts, the optical chamber becomes positioned for spectroscopic measurement. The present invention can provide joint-diagnostic spectroscopic and biosensor measurements.

Abstract: A system that is suitable for extracting plasma from blood received from a blood supply is provided. The system comprises a housing, an inlet opening for receiving the blood, a filtration chamber comprising a membrane, and a plasma compartment. The membrane forms a barrier between the blood and the plasma extracted from the blood, and the plasma compartment collects the plasma extracted from the blood. In some embodiments, the system comprises a plasma flow path compression chamber for pulling plasma across the membrane. In some embodiments, the system comprises a blood flow path compression chamber for facilitating blood flow. Some embodiments of the system further comprise means for measuring plasma and blood analytes using spectroscopic and biosensor techniques.

Abstract: A system that is suitable for extracting plasma from blood received from a blood supply is provided. The system comprises a housing, an inlet opening for receiving the blood, a filtration chamber comprising a membrane, and a plasma compartment. The membrane forms a barrier between the blood and the plasma extracted from the blood, and the plasma compartment collects the plasma extracted from the blood. In some embodiments, the system comprises a plasma flow path compression chamber for pulling plasma across the membrane. In some embodiments, the system comprises a blood flow path compression chamber for facilitating blood flow. Some embodiments of the system further comprise means for measuring plasma and blood analytes using spectroscopic and biosensor techniques.

Abstract: An apparatus suitable for measuring at least one plasma analyte in plasma extracted from a whole blood sample within the apparatus is provided. The apparatus can be adapted for insertion into a slot in a meter, which can preferably perform at least spectroscopic or biosensor measurement. The apparatus comprises a whole blood flow path, which begins at the inlet opening of the apparatus, and terminates at a vent or a suction chamber. Included in the blood flow path is a flow-through filtration chamber. The filtration chamber comprises at least one membrane separating a blood compartment from a plasma compartment. The apparatus further comprises a plasma flow path, which begins at the plasma compartment and terminates at a vent or a suction chamber. The plasma flow path includes a plasma analyte signal providing means. The signal is transmitted to a processor in the meter for preparing analyte measurements.

Abstract: A system that is suitable for extracting plasma from blood received from a blood supply is provided. The system comprises a housing, an inlet opening for receiving the blood, a filtration chamber comprising a membrane, and a plasma compartment. The membrane forms a barrier between the blood and the plasma extracted from the blood, and the plasma compartment collects the plasma extracted from the blood. In some embodiments, the system comprises a plasma flow path compression chamber for pulling plasma across the membrane. In some embodiments, the system comprises a blood flow path compression chamber for facilitating blood flow. Some embodiments of the system further comprise means for measuring plasma and blood analytes using spectroscopic and biosensor techniques.

Abstract: Some embodiments of the invention provide one sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some very specific embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells. Also, the sample holder is designed so that air bubbles are easily pushed through the optical chamber and guided out of the sample holder through a vent. In some embodiments, the inlet of the sample holder can be reconfigured with adaptors to receive blood from for example, a pin prick or a syringe. Use of adaptors makes the housing simpler when considering the manufacturing process.

Abstract: Some embodiments of the present invention provide a sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells using sound waves or reagents. The inlet of some embodiments of the sample holder is a piece of capillary tube, and in other embodiments, the inlet is configured to engage a syringe. In some embodiments, the inlet of the sample holder can accommodate adaptors with different configurations, thereby allowing the sample holder to receive blood from any source, for example a pin prick or a syringe.

Abstract: Some embodiments of the invention provide one sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some very specific embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells using sound waves or reagents. Also, the sample holder is designed so that air bubbles are easily pushed through the optical chamber and guided out of the sample holder through a vent. The inlet of some embodiments of a sample holder is a piece of capillary tube and in other embodiments, the inlet is configured to accept the male end of a syringe.

Abstract: Some analyzers cannot measure blood analytes from a sample of whole blood, but can measure the analytes in plasma extracted from the whole blood. Some embodiments of the invention provide a disposable apparatus that is suitable for extracting plasma from whole blood received from a blood supply. The blood supply includes one of a tube containing blood, a syringe containing blood, a drop of blood on the skin resulting from a pin prick, a vein, an artery, and an arterial line. The apparatus includes a housing, and arranged within the housing is a porous membrane, a filtration chamber, and a plasma collection chamber. The porous membrane forms a barrier between the whole blood and the plasma extracted from the whole blood. The filtration chamber receives the whole blood for plasma extraction, and the plasma collection chamber collects the plasma extracted from the whole blood. The apparatus also includes a blood flow path within the housing, and the blood flow path includes the filtration chamber.

Abstract: Some embodiments of the invention provide a needle comprising a shaft with a sharp open end and a hub with a blunt open end, housed in a barrel with an open anterior end and an open posterior end. The hub of the needle can move forward inside the barrel, for extending the sharp open end of the shaft of the needle for insertion into a vessel, e.g. a blood vessel, a catheter, or a capped tube. After use, the hub can move backwards inside the barrel for retracting the shaft of the needle into the barrel. The blunt open end of the needle can be fluidly connected to the inlet opening of a measurement apparatus, so that the blood can flow directly from a vessel, into the measurement apparatus, without the use of a syringe. The hollow needle assembly can also be used with a traditional syringe, as an alternative to traditional needles, in order to minimize the risk of needle-stick injury.

Abstract: Some embodiments of the invention provide one apparatus that is suitable for both the collection and measurement of a blood sample. Once a blood sample is drawn into such an apparatus the blood sample can be analyzed, without having to transfer any portion of the blood sample into another vessel. Also, in some very specific embodiments, the apparatus is provided with an optical chamber that is specifically designed to reduce the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells by using sound waves or by adding reagents to the blood sample. Moreover, as a result of the time saved by using a single apparatus for blood sample collection and measurement, the addition of an anticoagulant is not required to prevent clotting.