Patents Assigned to Chromocell Corporation
  • Publication number: 20210282443
    Abstract: The present disclosure provides edible compositions comprising a flavor-grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or a flavor-grade bitter taste blocker or a combination of flavor-grade bitter taste blockers of the present disclosure, food products comprising such edible compositions and methods of preparing such food products. The present disclosure also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
    Type: Application
    Filed: July 12, 2017
    Publication date: September 16, 2021
    Applicant: Chromocell Corporation
    Inventors: Dennis Sawchuk, Lori Schmid
  • Publication number: 20200297015
    Abstract: The present disclosure provides compounds of Formula (I) and edible compositions comprising compounds of Formula (I) which are suitable for use as sweeteners, for example, by incorporation into edible compositions. Also provided herein are methods of preparing comestible compositions comprising compounds of Formula (I).
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: CHROMOCELL CORPORATION
    Inventors: Deshou JIANG, Purvi SHAH, Dennis SAWCHUK
  • Patent number: 10407400
    Abstract: The present disclosure provides edible compositions comprising a flavor-grade sweet taste modulator or a combination of flavor-grade sweet taste modulators or a flavor-grade bitter taste blocker or a combination of flavor-grade bitter taste blockers of the present disclosure, food products comprising such edible compositions and methods of preparing such food products. The present disclosure also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: September 10, 2019
    Assignee: Chromocell Corporation
    Inventors: Deshou Jiang, Hao Zhou, Stuart Hayden
  • Patent number: 9927424
    Abstract: The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R38, TAS2R39, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: March 27, 2018
    Assignee: Chromocell Corporation
    Inventors: Harish Radhakrishna, Maya Jenkins, Jonathan Anobile, Louise Slade
  • Patent number: 9872514
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 23, 2018
    Assignee: Chromocell Corporation
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones
  • Publication number: 20170303574
    Abstract: The present invention provides edible compositions comprising a sweet taste modulator or bitter taste blocker of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste or blocking a bitter taste in a food product.
    Type: Application
    Filed: September 3, 2015
    Publication date: October 26, 2017
    Applicant: Chromocell Corporation
    Inventors: Robert Luo, Leonard McDonald, Deshou Jiang, Purvi Shah, Hao Zhou
  • Publication number: 20170304306
    Abstract: Provided herein are methods for treating or preventing prediabetes or diabetes, or maintaining or lowering blood or plasma glucose or maintaining or lowering blood or plasma glycated hemoglobin comprising administering to a subject in need thereof a therapeutically effective amount of a compound selectively inhibiting NaV1.7. In particular, provided herein are processes for the preparation of and intermediates used in the preparation of compounds selectively inhibiting NaV 1.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 26, 2017
    Applicant: CHROMOCELL CORPORATION
    Inventors: Yanlin WANG-FISCHER, Olga BABICH, Tina GARYANTES, Robert Z. LUO, Srinivasan P. Venkatachalan
  • Patent number: 9706790
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: July 18, 2017
    Assignee: CHROMOCELL CORPORATION
    Inventors: Francis Xavier Brennan, William P. Jones, Jane V. Leland, David Hayashi
  • Patent number: 9657357
    Abstract: The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs. The invention relates to methods for making cells comprising one or more reporter nucleic acid constructs using fluorogenic oligonucleotides. The methods relate to high throughput screens.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: May 23, 2017
    Assignee: CHROMOCELL CORPORATION
    Inventors: Kambiz Shekdar, Dennis J. Sawchuk, Jessica C. Langer
  • Patent number: 9534035
    Abstract: Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit combinations and various proteolyzed isoforms of ENaC and techniques for creating cell lines. The ENaC-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results.
    Type: Grant
    Filed: January 25, 2009
    Date of Patent: January 3, 2017
    Assignee: CHROMOCELL CORPORATION
    Inventors: Kambiz Shekdar, Jessica Langer, Dennis Sawchuk
  • Patent number: 9458118
    Abstract: Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I?: In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 4, 2016
    Assignee: Chromocell Corporation
    Inventors: Olga Babich, Tina Garyantes, Robert Z. Luo, David J. Palling, Srinivasan P. Venkatachalan, Yanlin Wang-Fischer
  • Patent number: 9408407
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 9, 2016
    Assignees: CHROMOCELL CORPORATION, KRAFT FOODS GROUP BRANDS LLC
    Inventors: Kambiz Shekdar, Daniel Lavery, Joseph Gunnet, Jessica Langer, Jane V. Leland, David Hayashi, Peter H. Brown, Louise Slade, William P. Jones
  • Publication number: 20160221974
    Abstract: Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I?: In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 4, 2016
    Applicant: CHROMOCELL CORPORATION
    Inventors: Olga BABICH, Tina GARYANTES, Robert Z. LUO, David J. PALLING, Srinivasan P. VENKATACHALAN, Yanlin WANG-FISCHER
  • Patent number: 9347934
    Abstract: The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: May 24, 2016
    Assignees: Chromocell Corporation, Kraft Foods Group Brands LLC
    Inventors: Kambiz Shekdar, Purvi Manoj Shah, Joseph Gunnet, Jane V. Leland, Peter H. Brown, Louise Slade
  • Publication number: 20160130239
    Abstract: Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I?: In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 12, 2016
    Applicant: CHROMOCELL CORPORATION
    Inventors: Olga BABICH, Tina GARYANTES, Robert Z. LUO, David J. PALLING, Srinivasan P. VENKATACHALAN, Yanlin WANG-FISCHER
  • Publication number: 20160046617
    Abstract: Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I: In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 18, 2016
    Applicant: CHROMOCELL CORPORATION
    Inventors: Olga BABICH, Robert Z. LUO, Yanlin WANG-FISCHER, David J. PALLING, Srinivasan P. VENKATACHALAN
  • Publication number: 20160015064
    Abstract: The present invention provides edible compositions comprising a sweet taste modulator of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste in a food product.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Applicant: CHROMOCELL CORPORATION
    Inventors: Robert Zhiyong Luo, Kevin Joseph Curran, Stuart Hayden, Gengcheng Yang, Deshou Jiang, Vincent Kral
  • Publication number: 20150050410
    Abstract: The present invention provides edible compositions comprising a sweet taste modulator of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of sugar in a food product, methods of reducing the caloric intake in a diet, and methods of enhancing sweet taste in a food product.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 19, 2015
    Applicant: CHROMOCELL CORPORATION
    Inventors: Robert Zhiyong Luo, Kevin Joseph Curran, Stuart Hayden, Gengcheng Yang
  • Patent number: 8945848
    Abstract: The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs. The invention relates to methods for making cells comprising one or more reporter nucleic acid constructs using fluorogenic oligonucleotides. The methods relate to high throughput screens.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: February 3, 2015
    Assignee: Chromocell Corporation
    Inventors: Kambiz Shekdar, Dennis J. Sawchuk, Jessica C. Langer
  • Publication number: 20140377381
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Application
    Filed: October 20, 2011
    Publication date: December 25, 2014
    Applicants: KRAFT FOODS GROUP BRANDS LLC, CHROMOCELL CORPORATION
    Inventors: Francis Xavier Brennan, William P. Jones, Jane V. Leland, David Hayashi