Patents Assigned to Chromocenter Inc.
  • MOUSE ARTIFICIAL CHROMOSOME VECTOR
    Publication number: 20150096063
    Abstract: Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm distal region at a mouse chromosome long-arm site proximal to the centromere; and a telomere sequence, wherein the vector is stably retained in a cell and/or tissue of a mammal. In addition, disclosed are cells or non-human animals comprising the vector, and use of the cells or non-human animals.
    Type: Application
    Filed: December 18, 2014
    Publication date: April 2, 2015
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, CHROMOCENTER INC.
    Inventors: Mitsuo Oshimura, Yasuhiro Kazuki, Masato Takiguchi, Takashi Matsuoka
  • Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same
    Patent number: 8951789
    Abstract: This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb±500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: February 10, 2015
    Assignees: National University Corporation Tottori University, Chromocenter Inc.
    Inventors: Mitsuo Oshimura, Yasuhiro Kazuki, Takashi Matsuoka, Kazuma Tomizuka, Takeshi Oshima
  • Mouse artificial chromosome vector
    Patent number: 8940533
    Abstract: Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm distal region at a mouse chromosome long-arm site proximal to the centromere; and a telomere sequence, wherein the vector is stably retained in a cell and/or tissue of a mammal. In addition, disclosed are cells or non-human animals comprising the vector, and use of the cells or non-human animals.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: January 27, 2015
    Assignees: National University Corporation Tottori University, Chromocenter Inc.
    Inventors: Mitsuo Oshimura, Yasuhiro Kazuki, Masato Takiguchi, Takashi Matsuoka
  • MAMMALIAN ARTIFICIAL CHROMOSOME VECTOR COMPRISING HUMAN CYTOCHROME P450 GENE (CLUSTER) AND NON-HUMAN MAMMALIAN ANIMAL RETAINING THE SAME
    Publication number: 20110023138
    Abstract: This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb±500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector.
    Type: Application
    Filed: October 14, 2008
    Publication date: January 27, 2011
    Applicants: National University Corporation Tottori University, Chromocenter Inc.
    Inventors: Mitsuo Oshimura, Yasuhiro Kazuki, Takashi Matsuoka, Kazuma Tomizuka, Takeshi Oshima