Patents Assigned to Chromos Molecular Systems Inc.
  • Methods for delivering nucleic acid molecules into cells and assessment thereof
    Patent number: 7294511
    Abstract: Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: November 13, 2007
    Assignee: Chromos Molecular Systems, Inc.
    Inventors: Gary deJong, Sandra Louise Vanderbyl, Volker Oberle, Dirk Hoekstra
  • Methods for delivering nucleic acid molecules into cells and assessment thereof
    Patent number: 6936469
    Abstract: Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: August 30, 2005
    Assignee: Chromos Molecular Systems Inc.
    Inventors: Gary deJong, Sandra Louise Vanderbyl
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6743967
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heteroaromatic are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: June 1, 2004
    Assignees: Chromos Molecular Systems Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Methods for delivering nucleic acid molecules into cells and assessment thereof
    Publication number: 20030113917
    Abstract: Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
    Type: Application
    Filed: September 3, 2002
    Publication date: June 19, 2003
    Applicant: Chromos Molecular Systems, Inc.
    Inventors: Gary de Jong, Sandra Louise Vanderbyl, Jan Drayer, Paul Peter Tak
  • Methods for delivering nucleic acid molecules into cells and assessment thereof
    Publication number: 20030003435
    Abstract: Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
    Type: Application
    Filed: March 22, 2001
    Publication date: January 2, 2003
    Applicant: CHROMOS MOLECULAR SYSTEMS, INC.
    Inventors: Gary DeJong, Sandra Louise Vanderbyl
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6077697
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: June 20, 2000
    Assignees: Chromos Molecular Systems, Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 6025155
    Abstract: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: February 15, 2000
    Assignees: Chromos Molecular Systems, Inc., The Biological Research Center of the Hungarian Academy of Sciences
    Inventors: Gyula Hadlaczky, Aladar A. Szalay