Patents Assigned to Chrysalis Biotechnology, Inc.
  • Synthetic peptide neutrophil cell chemotactic agents
    Publication number: 20020032314
    Abstract: These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neutrophils. Neutrophil response to this peptide is specific, since monocytes and fibroblasts do not show any expression of this receptor. Antibodies against these peptides block the chemotactic response. Such antibodies are useful to modulate neutrophil recruitment to a wound site for enhancing or inhibiting inflammation and early effects of wound healing.
    Type: Application
    Filed: February 5, 2001
    Publication date: March 14, 2002
    Applicant: Chrysalis Biotechnology, Inc.
    Inventors: Darrell H. Carney, Shyam Ramakrishnan
  • Synthetic peptide neutrophil cell chemotactic agents
    Patent number: 6184342
    Abstract: These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neutrophils. Neutrophil response to this peptide is specific, since monocytes and fibroblasts do not show any expression of this receptor. Antibodies against these peptides block the chemotactic response. Such antibodies are useful to modulate neutrophil recruitment to a wound site for enhancing or inhibiting inflammation and early effects of wound healing.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: February 6, 2001
    Assignee: Chrysalis Biotechnology, Inc.
    Inventors: Darrell H. Carney, Shyam Ramakrishnan