Patents Assigned to Chrysalis Pharma AG
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Patent number: 10314789Abstract: Shelf life of soft gelatin capsules comprising a soft gelatin shell encapsulating a pharmaceutical formulation comprising cis-5,8,11,14,17-eicosapentaenoic acid (C20:5 n-3; “EPA”) in free acid form in an amount from 25 wt % to 99 wt % of the formulation and cis-7,10,13,16,19-docosapentaenoic acid (C22:5 n-3; “DPA”) in free acid form in an amount from 1 wt % to 75 wt % of the formulation in which the gelatin component of the shell is Type B gelatin, is improved by replacing up to 75 wt % of the gelatin component with porcine Type A gelatin.Type: GrantFiled: September 6, 2013Date of Patent: June 11, 2019Assignee: Chrysalis Pharma AGInventor: Johannes Spleiss
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Publication number: 20190167599Abstract: Shelf life of soft gelatin capsules comprising a soft gelatin shell encapsulating a pharmaceutical formulation comprising cis-5,8,11,14,17-eicosapentaenoic acid (C20:5 n-3; “EPA”) in free acid form in an amount from 25 wt % to 99 wt % of the formulation and cis-7,10,13,16,19-docosapentaenoic acid (C22:5 n-3; “DPA”) in free acid form in an amount from 1 wt % to 75 wt % of the formulation in which the gelatin component of the shell is Type B gelatin, is improved by replacing up to 75 wt % of the gelatin component with porcine Type A gelatin.Type: ApplicationFiled: January 24, 2019Publication date: June 6, 2019Applicant: Chrysalis Pharma AGInventor: Johannes SPLEISS
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Patent number: 10117844Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.Type: GrantFiled: April 29, 2015Date of Patent: November 6, 2018Assignees: Omthera Pharmaceuticals, Inc., Chrysalis Pharma AGInventors: Timothy J. Maines, Bernardus N. Machielse, Bharat M. Mehta, Gerald L. Wisler, Michael H. Davidson, Peter Ralph Wood
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Publication number: 20170056354Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft to gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: ApplicationFiled: November 14, 2016Publication date: March 2, 2017Applicant: Chrysalis Pharma AGInventors: Jean-Pierre SACHETTO, Roly BUFTON, Thomas BUSER
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Publication number: 20150297529Abstract: Shelf life of soft gelatin capsules comprising a soft gelatin shell encapsulating a pharmaceutical formulation comprising cis-5,8,11,14,17-eicosapentaenoic acid (C20:5 n-3; “EPA”) in free acid form in an amount from 25 wt % to 99 wt % of the formulation and cis-7,10,13,16,19-docosapentaenoic acid (C22:5 n-3; “DPA”) in free acid form in an amount from 1 wt % to 75 wt % of the formulation in which the gelatin component of the shell is Type B gelatin, is improved by replacing up to 75 wt % of the gelatin component with porcine Type A gelatin.Type: ApplicationFiled: September 6, 2013Publication date: October 22, 2015Applicant: CHRYSALIS PHARMA AGInventor: Johannes Spleiss
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Publication number: 20150238430Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: ApplicationFiled: April 29, 2015Publication date: August 27, 2015Applicant: Chrysalis Pharma AGInventors: Jean-Pierre SACHETTO, Roly BUFTON, Thomas BUSER
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Patent number: 9050309Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.Type: GrantFiled: March 12, 2013Date of Patent: June 9, 2015Assignees: Omthera Pharmaceuticals, Inc., Chrysalis Pharma AGInventors: Timothy J. Maines, Bernardus N M Machielse, Bharat M. Mehta, Gerald L. Wisler, Michael H. Davidson, Peter Ralph Wood
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Patent number: 9050308Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.Type: GrantFiled: January 4, 2013Date of Patent: June 9, 2015Assignees: Omthera Pharmaceuticals, Inc., Chrysalis Pharma AGInventors: Timothy J. Maines, Bernardus N M Machielse, Bharat M. Mehta, Gerald L. Wisler, Michael H. Davidson, Peter Ralph Wood
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Patent number: 9012501Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft to gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: GrantFiled: January 4, 2013Date of Patent: April 21, 2015Assignee: Chrysalis Pharma AGInventors: Jean-Pierre Sachetto, Roly Bufton, Thomas Buser
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Publication number: 20140228437Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterised in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: ApplicationFiled: April 22, 2014Publication date: August 14, 2014Applicant: Chrysalis Pharma AGInventors: Jean-Pierre SACHETTO, Roly BUFTON, Thomas BUSER
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Publication number: 20130209556Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.Type: ApplicationFiled: March 12, 2013Publication date: August 15, 2013Applicants: Chrysalis Pharma AG, Omthera Pharmaceuticals, Inc.Inventors: Omthera Pharmaceuticals, Inc., Chrysalis Pharma AG
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Publication number: 20130177643Abstract: DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented.Type: ApplicationFiled: January 4, 2013Publication date: July 11, 2013Applicants: Chrysalis Pharma AG, Omthera Pharmaceuticals, Inc.Inventors: Omthera Pharmaceuticals, Inc., Chrysalis Pharma AG
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Patent number: 8383678Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: GrantFiled: January 5, 2011Date of Patent: February 26, 2013Assignee: Chrysalis Pharma AGInventors: Jean-Pierre Sachetto, Roly Bufton, Thomas Buser