Abstract: A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and/or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

Abstract: A fuel system for use in an internal combustion engine includes a plurality of fuel injectors, each injector including at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat a liquid fuel in the at least one capillary flow passage to a level sufficient to convert at least a portion thereof from the liquid state to a vapor state, and a valve for metering fuel to the internal combustion engine, a controller to control the power supplied to the heat source of each of the plurality of fuel injectors to achieve a predetermined target temperature, a sensor for use in determining engine air flow and a sensor for measuring a value indicative of degree of engine warm-up of the internal combustion engine.

Abstract: A fuel system for use in an internal combustion engine includes a plurality of fuel injectors, each injector including at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat a liquid fuel in the at least one capillary flow passage to a level sufficient to convert at least a portion thereof from the liquid state to a vapor state, and a valve for metering fuel to the internal combustion engine, a controller to control the power supplied to the heat source of each of the plurality of fuel injectors to achieve a predetermined target temperature, a sensor for use in determining engine air flow and a sensor for measuring a value indicative of degree of engine warm-up of the internal combustion engine.

Abstract: A method is provided for generating an aerosol. The method includes preparing a solution formed of a first component in a liquid component such that after volatilization of the liquid component by passing the solution through a flow passage while heating the solution, an aerosol is formed having a predetermined particle size distribution of the first component, wherein the solution is prepared such that the amount of the first component therein is sufficient to achieve the predetermined particle size distribution of the first component. The method also includes passing the solution through the flow passage while heating the solution to a temperature sufficient to volatilize the liquid component, wherein the flow passage comprises an outlet through which the first component and the volatilized liquid component flow, and wherein an aerosol is formed.

Abstract: A method and apparatus for vaporizing liquid fuel. The apparatus includes at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end; a fluid control valve for placing the inlet end of the at least one capillary flow passage in fluid communication with the liquid fuel source and introducing the liquid fuel in a substantially liquid state; a heat source arranged along the at least one capillary flow passage, the heat source operable to heat the liquid fuel in the at least one capillary flow passage to a level sufficient to change at least a portion thereof from the liquid state to a vapor state and deliver a stream of substantially vaporized fuel from the outlet end of the at least one capillary flow passage; and means for cleaning deposits formed during operation of the apparatus. The flow passage can be a capillary tube heated by a resistance heater or a section of a tube heated by passing electrical energy therethrough.

Abstract: An apparatus and method for improving the transient response of a spark-ignited fuel-injected internal combustion engine is disclosed. This is accomplished by employing one or more novel capillary fuel injectors. These devices are port fuel injectors modified by inserting one or more relatively small diameter heated tubular capillaries between the fuel line and a conventional injector. Sufficient heating can be produced so that flash vaporization occurs as the fuel exits the injector. The heaters are turned on using control algorithms that can be based on exhaust gas oxygen concentration, load on the engine, and accelerator pedal position.

Abstract: A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and/or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

Abstract: A cracking tube includes a lining of a fouling resistant and corrosion resistant iron aluminide alloy. The iron aluminide alloy can include 14-32 wt. % Al, at least 2 vol. % transition metal oxides, 0.003 to 0.020 wt. % B, 0.2 to 2.0 wt. % Mo, 0.05 to 1.0 wt. % Zr, 0.2 to 2.0 wt. % Ti, 0.10 to 1.0 wt. % La, 0.05 to 0.2 wt. % C., balance Fe, and optionally ≦1 wt. % Cr, and the coefficient of thermal expansion of the iron aluminide alloy is substantially the same as the coefficient of thermal expansion over the temperature range of ambient to about 1200° C. of an outer metal layer. A cracking tube utilizing the iron aluminide alloy can be formed from powders of the iron aluminide alloy by consolidation methods including cold isostatic pressing (CIP), hot isostatic pressing (HIP), reaction synthesis, spraying techniques, or co-extrusion with a second material of the cracking tube.

Abstract: A fuel injector for vaporizing a liquid fuel for use in an internal combustion engine. The fuel injector includes at least one capillary flow passage, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat the liquid fuel in the at least one capillary flow passage to a level sufficient to change at least a portion thereof from the liquid state to a vapor state and deliver a stream of substantially vaporized fuel from the outlet end of the at least one capillary flow passage; and a valve for metering fuel to the internal combustion engine, the valve located proximate to the outlet end of the at least one capillary flow passage, the valve including a low mass member for substantially occluding the stream of fuel to the internal combustion engine; wherein the low mass member for substantially occluding the stream of fuel to the internal combustion engine is formed of a material having low mass and or a low coefficient of thermal conductivity.

Abstract: Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of the carrier. The carrier can be a mixture of ethanol and water and the liquid aerosol formulation can be propellant free. An aerosol generating device generates the aerosolized insulin by passing the liquid aerosol formulation through a flow passage heated to convert the liquid into a vapor which entrains insulin particles which mix with air to form an aerosol. The insulin particles can be dry insulin particles produced by a hand held inhaler. By controlling the concentration of the insulin in the formulation, the size of the flow passage and/or the amount of heat which heats the flow passage, the aerosol can be provided with a selected mass median aerodynamic diameter of 1 to 3 &mgr;m or less than 1 &mgr;m so as to be delivered to a targeted portion of the lung using the inhaler.

Abstract: Liquid aerosol formulations for generating cromolyn sodium aerosols include at least one high volatility carrier and an optional additive such as a surfactant and/or low volatility liquid. In some embodiments, the liquid aerosol formulation is propellant free. An aerosol generating device generates an aerosol by passing liquid aerosol formulation through a flow passage heated to convert at least some of the liquid into a vapor, which is mixed with air to form an aerosol. In some embodiments, particles of the aerosol consist essentially of the cromolyn sodium or cromolyn sodium in combination with an additive such as a surfactant and/or low volatility liquid. The aerosol generator can be incorporated in a hand held inhaler and the aerosol can be delivered to a targeted portion of the lung using the inhaler for treatment of asthma.

Abstract: An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

Abstract: A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and/or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

Abstract: An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater, which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together, and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets, and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

Abstract: A fuel injector for vaporizing a liquid fuel for use in an internal combustion engine. The fuel injector includes at least one capillary flow passage, the at least one capillary flow passage having an inlet end and an outlet end, a fluid control valve for placing the inlet end of the at least one capillary flow passage in fluid communication with the liquid fuel source and introducing the liquid fuel in a substantially liquid state, a heat source arranged along the at least one capillary flow passage, the heat source operable to heat the liquid fuel in the at least one capillary flow passage to a level sufficient to change at least a portion thereof from the liquid state to a vapor state and deliver a stream of substantially vaporized fuel from the outlet end of the at least one capillary flow passage and means for cleaning deposits formed during operation of the apparatus. The fuel injector is effective in reducing cold-start and warm-up emissions of an internal combustion engine.

Abstract: A fluid vaporizing device includes two concentric, electrically conductive tubes, the tubes being electrically and physically connected near a distal end of the tubes, and the tubes each having electrical connections to the power source, with the electrical connections to a power source being near a proximal end of the tubes. The proximal end of an inner one of the tubes is in fluid communication with a source of fluid. The device can be used to aerosolize medicament containing solutions to produce an aerosol with particles within a desired size range.

Abstract: A programmable aerosol generator forms a volatilized liquid by supplying a material in liquid form to a flow passage and heating the flow passage, such that the material volatilizes and expands out of an outlet of the channel. The volatilized material, if desired, mixes with ambient air such that volatilized material condenses to form the aerosol. An apparatus and method for generating such a volatilized liquid, as well as the control and methods of heating, are disclosed as an analytical tool useful for experimental use, a tool useful for production of commercial products or an inhaler device.

Abstract: An aerosol generating device generates an aerosol having a desired particle size by passing a liquid through a flow passage heated to convert the liquid into a vapor. The flow passage includes an outlet section that controls the exit velocity of the vapor and produces an aerosol with a desired particle size. The aerosol generator can be incorporated in a hand held inhaler, and the liquid can include a medicament, which is delivered to a targeted portion of the lung using the inhaler.

Abstract: Nanoparticles of intermetallic alloys such as FeAl, Fe3Al, NiAl, TiAl and FeCoV exhibit a wide variety of interesting structural, magnetic, catalytic, resistive and electronic, and bar coding applications. The nanosized powders can be used to make structural parts having enhanced mechanical properties, magnetic parts having enhanced magnetic saturation, catalyst materials having enhanced catalytic activity, thick film circuit elements having enhanced resolution, and screen printed images such as magnetic bar codes having enhanced magnetic properties. In contrast to bulk FeAl materials which are nonmagnetic at room temperature, the FeAl nanoparticles exhibit magnetic properties at room temperature.