Patents Assigned to CHU DE BORDEAUX
  • Methods for predicting acute severe colitis treatment response
    Patent number: 11060147
    Abstract: The present invention relates to methods for predicting acute severe colitis treatment response. Currently, there is no biomarker of drug response. The present invention provides the first prediction tool for responses to first- and second-line treatments in acute severe ulcerative colitis. Putative mRNA targets of dysregulated microRNAs were identified from patient biopsies. One classifier of fifteen colonic microRNAs plus five biological values at admission were identified with a prediction accuracy of 96.6% for discriminating responders from non-responders to steroids. Using a similar method, 6 and 4 mucosal microRNA-based algorithms were identified to classify responders from non-responders to infliximab and cyclosporine.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: July 13, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE PARIS, ASSISTANCE PUBLIQUE-HOPPITAUX DE PARIS (APHP), UNIVERSITE DE BORDEAUX, CHU DE BORDEAUX, UNIVERSITE PARIS XIII PARIS-NORD
    Inventors: Eric Ogier-Denis, Xavier Treton, Yoram Bouhnik, Ian Morilla, David Laharie, Gilles Wainrib, Mathieu Uzzan
  • Methods and pharmaceutical compositions for the treatment of ebola virus disease
    Patent number: 10098879
    Abstract: The invention relates to methods and pharmaceutical compositions for the treatment of Ebola Virus Disease. In particular the present relates to a method of treating Ebola Virus Disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of Favipiravir.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: October 16, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE BORDEAUX, CHU DE BORDEAUX, TOYAMA CHEMICAL CO., LTD
    Inventors: Denis Malvy, Sylvain Baize, Xavier De Lamballerie, Hervé Raoul, Cédric Laouenan, Jeremie Guedj, France Mentre
  • MATRIX METALLOPROTEINASE 9 (MMP-9) APTAMER AND USES THEREOF
    Publication number: 20150337308
    Abstract: The present invention relates to a nucleic acid aptamer that binds specifically to human matrix metalloproteinase 9 (h MMP-9) and its use for imaging h MMP-9 in a subject in need thereof.
    Type: Application
    Filed: April 11, 2013
    Publication date: November 26, 2015
    Applicant: CHU DE BORDEAUX
    Inventors: Jean-Jacques Toulme, Sonia Da Rocha, Eric Dausse, Michele Allard, Laurent Azema