Patents Assigned to CHU Sainte-Justine
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Patent number: 11860169Abstract: The present invention provides a method of treating a subject in need thereof comprising classifying the subject into functional group FG1, FG2 or FG3, wherein i) when the subject is classified into the FG1 functional group, (A) the level of OPN or the activity of OPN in said subject is increased; (B) the subject is not treated with a brace; or (C) a combination of (A) and (B); and ii) when the subject is classified into the FG2 or FG3 functional group, (A) the level of OPN or the activity of OPN in said subject is decreased; (B) the subject is treated with a brace; or (C) a combination of (A) and (B).Type: GrantFiled: September 8, 2020Date of Patent: January 2, 2024Assignee: CHU SAINTE-JUSTINEInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20210322509Abstract: A method for preventing or reducing the risk of perinatal or neonatal morbidity and mortality caused by antenatal inflammation in humans is described. This method is based on the administration of a compound of formula I or a pharmaceutically acceptable salt thereof: to an expectant human mother suffering from antenatal fetal inflammation. The method prevents or reduces the risk of organ damages, including brain, lung and intestinal damages, and sequelae therefrom, in the neonates, as well as the risk of neonatal death.Type: ApplicationFiled: June 30, 2021Publication date: October 21, 2021Applicants: CHU SAINTE-JUSTINE, UNIVERSITÉ DE MONTRÉAL, THE UNIVERSITY OF ADELAIDEInventors: Sylvain CHEMTOB, Christiane QUINIOU, Sarah Anne ROBERTSON, Mathieu NADEAU-VALLÉE, William D. LUBELL, David OLSON, Peck Yin CHIN, Sylvie GIRARD, Doan-Ngoc DUC
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Patent number: 10620222Abstract: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.Type: GrantFiled: July 20, 2015Date of Patent: April 14, 2020Assignee: CHU Sainte-JustineInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20190195859Abstract: Disclosed herein are novel molecular markers associated with idiopathic scoliosis (IS). Accordingly, the present invention concerns novel methods of identifying subjects at risk of developing IS or suffering from IS and of genotyping and classifying IS subjects into genetic and functional groups. Also provided are compositions, DNA chips and kits for applying the methods.Type: ApplicationFiled: August 23, 2017Publication date: June 27, 2019Applicant: CHU Sainte-JustineInventors: Alain Moreau, Niaz Oliazadeh, Kristen Fay Gorman, Robert Eveleigh, Guillaume Bourque
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Publication number: 20190178896Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.Type: ApplicationFiled: February 15, 2019Publication date: June 13, 2019Applicant: Chu Sainte-JustineInventors: Alain Moreau, Marie - Yvonne Akoume Ndong
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Patent number: 10247737Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.Type: GrantFiled: September 9, 2014Date of Patent: April 2, 2019Assignee: Chu Sainte-JustineInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Patent number: 10073101Abstract: A method for the prevention or treatment of scoliosis in a human subject comprising: (a)(i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or (ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis.Type: GrantFiled: July 23, 2015Date of Patent: September 11, 2018Assignee: CHU SAINTE-JUSTINEInventor: Alain Moreau
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Patent number: 9989531Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1? tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1? expression and/or activity.Type: GrantFiled: June 17, 2014Date of Patent: June 5, 2018Assignee: Chu Sainte-JustineInventors: Alain Moreau, Marie-Yvonne Akoume Ndong, Mohamed Elbakry
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Publication number: 20160291016Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTP? expression and/or activity and/or PIPK1? expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1? tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1? expression and/or activity.Type: ApplicationFiled: June 17, 2014Publication date: October 6, 2016Applicant: Chu Sainte-JustineInventors: Alain Moreau, Marie - Yvonne Akoume Ndong, Mohamed Elbakry
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Publication number: 20160223567Abstract: The present invention provides a method of predicting brace treatment outcome in a subject in need thereof comprising i) classifying the subject into functional group FG1, FG2 or FG3, wherein the classification enables the prediction of brace treatment outcome. Also provided are methods of determining risk of developing scoliosis, methods of treating Idiopathic scoliosis and kits for applying the methods.Type: ApplicationFiled: September 9, 2014Publication date: August 4, 2016Applicant: Chu Sainte-JustineInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20160216277Abstract: A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.Type: ApplicationFiled: September 9, 2014Publication date: July 28, 2016Applicant: Chu Sainte-JustineInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20160146839Abstract: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.Type: ApplicationFiled: July 20, 2015Publication date: May 26, 2016Applicant: CHU SAINTE-JUSTINEInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20160139146Abstract: Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Gi? protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Gi? and Gs? protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Gi?1 and/or Gi?3 proteins in the cell sample, and/or determining a ratio between the response to Gi? protein stimulation and the response to Gs? protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor.Type: ApplicationFiled: June 16, 2014Publication date: May 19, 2016Applicant: CHU SAINTE-JUSTINEInventors: Alain Moreau, Marie-Yvonne Akoume Ndong
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Publication number: 20150323553Abstract: A method for the prevention or treatment of scoliosis in a human subject comprising: (a)(i) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject over time; or (ii) measuring osteopontin (OPN) protein expression in a biological fluid sample from the subject and comparing the OPN protein expression to an OPN protein expression in a control biological fluid sample; (b) identifying the subject as being at risk of developing scoliosis when OPN protein expression increases in the subject sample over time; or when OPN protein expression is higher in the subject sample than that in the control sample; and (c) reducing OPN protein levels in the subject identified as being at risk of developing a scoliosis, thereby aiding in the prevention or treatment of scoliosis.Type: ApplicationFiled: July 23, 2015Publication date: November 12, 2015Applicant: CHU SAINTE-JUSTINEInventor: Alain Moreau
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Patent number: 9029094Abstract: Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and/or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces/stimuli are described.Type: GrantFiled: October 4, 2011Date of Patent: May 12, 2015Assignee: Chu Sainte-JustineInventors: Alain Moreau, Guoruey Wong
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Publication number: 20130266966Abstract: A method for determining the risk for developing a scoliosis comprising monitoring osteopontin (OPN) expression in a sample from a subject over time; wherein an OPN expression that increases in the subject sample over time is indicative that the subject is at risk for developing a scoliosis.Type: ApplicationFiled: February 22, 2013Publication date: October 10, 2013Applicant: CHU SAINTE-JUSTINEInventor: Alain Moreau
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Publication number: 20130183695Abstract: Methods for diagnosing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and/or a predisposition to developing a scoliosis based on the determination of the variation of osteopontin (OPN) levels induced by mechanical forces/stimuli are described.Type: ApplicationFiled: October 4, 2011Publication date: July 18, 2013Applicant: CHU SAINTE- JUSTINEInventors: Alain Moreau, Guoruey Wong
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Publication number: 20130029871Abstract: A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitx1) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to an AIS subclass.Type: ApplicationFiled: October 2, 2012Publication date: January 31, 2013Applicant: CHU SAINTE-JUSTINEInventor: Chu Sainte-Justine
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Patent number: 8222298Abstract: Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2-propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof, are described.Type: GrantFiled: November 25, 2011Date of Patent: July 17, 2012Assignee: CHU Sainte-JustineInventors: Alain Moreau, Genevieve Mailhot
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Patent number: 8129432Abstract: Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2 propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof, are described.Type: GrantFiled: February 15, 2008Date of Patent: March 6, 2012Assignee: CHU Sainte-JustineInventors: Alain Moreau, Genevieve Mailhot