Patents Assigned to Chung Shan Medical University
  • Publication number: 20230377745
    Abstract: A method of establishing a clinical decision support system for SPC risk evaluation among patients with colorectal cancer includes combining cancer characteristics into a characteristic assembly of SPC risk evaluation; obtaining clinical data of first participants to establish a database of SPC risk evaluation; entering the database into a machine learning algorithm; using the machine learning algorithms to establish a SPC risk evaluation model; using a characteristic interpreter to analyze the model; calculating a risk value of each cancer characteristic; presenting the risk values in graphics to establish a clinical decision support system; obtaining clinical data of second participants and inputting same into the clinical decision support system; using the machine learning algorithm for comparison and analysis; predicting risk for SPC; calculating a risk value of each cancer characteristic; presenting the risk values on the clinical decision support system; giving suggestions of decreasing risk; and monito
    Type: Application
    Filed: May 17, 2022
    Publication date: November 23, 2023
    Applicant: Chung Shan Medical University
    Inventors: Chi-Chang Chang, Chi-Jie Lu, Yi-Ju Tseng, Ssu-Han Chen, Chin-Jen Tseng
  • Publication number: 20230215001
    Abstract: A method for facilitating caries detection is to be performed based on a grayscale image of teeth, and includes: obtaining an object detection model; obtaining a detection image using the object detection model based on the grayscale image, wherein the detection image is the grayscale image labeled with a plurality of tooth crown marks and a caries mark; and for one of the tooth crown marks that has the caries mark provided thereon, determining a width and a height of the tooth crown mark and a width and a height of the caries mark, and calculating a caries ratio based on the aforementioned widths and heights to obtain an evaluation result that indicates a severity of caries.
    Type: Application
    Filed: December 16, 2022
    Publication date: July 6, 2023
    Applicant: CHUNG SHAN MEDICAL UNIVERSITY
    Inventors: Chia-Tze KAO, Chih-Jen TSENG
  • Patent number: 11591368
    Abstract: The invention pertains to cancer treatment or prevention field. Particularly, the invention provides peptide fragments from SLIT2 protein and their applications in inhibition of cancer growth, invasion and metastasis.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 28, 2023
    Assignees: CHUNG SHAN MEDICAL UNIVERSITY, TUNGHAI UNIVERSITY
    Inventors: Jinghua Tsai Chang, Feng-Di Lung
  • Patent number: 11197904
    Abstract: The present invention relates to the area of pharmaceutical compositions. More particularly, the present invention relates to a series of pharmaceutical compositions (PTM) containing phyto-polyphenols (P), clinical drugs with selective targets (T) and a metal ions (M) and the methods thereof for use in prevention and therapy of infectious diseases, neurodegenerative diseases, dementia, diabetes, obesity, metabolic syndromes, osteoporosis, cancers and/or chronic pain.
    Type: Grant
    Filed: January 20, 2019
    Date of Patent: December 14, 2021
    Assignees: Chung Shan Medical University
    Inventor: Shoei-Yn Lin-Shiau
  • Publication number: 20210346444
    Abstract: The present invention provides a composition comprising Nelumbo nucifera leaf extract and a method for the increase of adult hippocampal neurogenesis.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 11, 2021
    Applicant: Chung Shan Medical University
    Inventors: Chau-Jong Wang, Yen-Ling Chang
  • Publication number: 20210038567
    Abstract: The present invention relates to a method for inhibiting a cancer metastasis in a subject in need thereof, comprising administering to said subject a cancer metastasis-inhibiting effective amount of: Camphorataimide B; or a composition comprising Camphorataimide B and a pharmaceutically acceptable adjuvant, vehicle, or carrier.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 11, 2021
    Applicant: Chung Shan Medical University
    Inventors: Chau-Jong Wang, Chia-Hung Hung
  • Patent number: 10912760
    Abstract: The present invention relates to a method for inhibiting a cancer metastasis in a subject in need thereof, comprising administering to said subject a cancer metastasis-inhibiting effective amount of: Camphorataimide B; or a composition comprising Camphorataimide B and a pharmaceutically acceptable adjuvant, vehicle, or carrier.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: February 9, 2021
    Assignee: Chung Shan Medical University
    Inventors: Chau-Jong Wang, Chia-Hung Hung
  • Patent number: 10448878
    Abstract: Many electrodes are positioned inside a skull for obtaining several electric voltage variation wave information. A processing unit computes subtract operation between two neighboring electrical voltage variation wave information respectively and then can obtain electrical voltage difference waves. Furthermore, each electrical voltage difference wave is separated into a first band wave signal and a second band wave signal. After which, several first band wave envelope signals and second band wave envelope signals are obtained. It conducts a co-relation processing about the first band wave envelope signals and the second band wave envelope signals. So, a co-relation table is obtained for determining a position where an intracranial brain wave abnormality occurs. In this invention, a unique scientific approach to determine the spatial position of seizure onset occurred inside the brain. In addition, the position of intracranial brain wave abnormality can be concretized and visualized by the co-relation table.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 22, 2019
    Assignee: CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL
    Inventors: Yue-Loong Hsin, Syu-Jyun Peng
  • Publication number: 20170246233
    Abstract: The invention relates to a method of decreasing blood sugar by inhibition of ?-glucosidase activity in a subject in need thereof, comprising administering pu-erh tea polysaccharides (PTPS) to the subject, wherein the active ingredients in PTPS are neutral sugar, protein, polyphenol, and uronic acids.
    Type: Application
    Filed: February 26, 2016
    Publication date: August 31, 2017
    Applicant: Chung Shan Medical University
    Inventors: Shoei-Yn Lin-Shiau, Jen-Kun Lin
  • Publication number: 20160263050
    Abstract: The present invention provides a method for inducing death of a cancer cell in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of Nelumbo Nucifera leave water extract, wherein the Nelumbo Nucifera leave water extract comprises polyphenols.
    Type: Application
    Filed: March 13, 2015
    Publication date: September 15, 2016
    Applicant: Chung Shan Medical University
    Inventors: Chau-Jong Wang, Mon-Yuan Yang, Tzu-Hsin Chen
  • Patent number: 9326988
    Abstract: Disclosed herein is a method for treatment of a human subject having or suspected of having Parkinson's disease dementia, which includes administering to the human subject ceftriaxone at a daily dosage ranging from about 1.5 mg to about 35 mg per kilogram of a body weight of the human subject.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 3, 2016
    Assignees: CHUNG SHAN MEDICAL UNIVERSITY, TL & GM CHEMICAL COMPANY
    Inventor: Ying-Jui Ho
  • Publication number: 20130296294
    Abstract: Disclosed herein is a method for treatment of a human subject having or suspected of having Parkinson's disease dementia, which includes administering to the human subject ceftriaxone at a daily dosage ranging from about 1.5 mg to about 35 mg per kilogram of a body weight of the human subject.
    Type: Application
    Filed: March 13, 2013
    Publication date: November 7, 2013
    Applicants: TL & GM Chemical Company, CHUNG SHAN MEDICAL UNIVERSITY
    Inventor: Ying-Jui HO
  • Publication number: 20110232533
    Abstract: One aspect of the present invention provides a method for producing calcium silicate-based bone cement, including the steps of mixing calcium salt with silicohydrides to form a first mixture; processing the first mixture with a sol-gel process to form a second mixture; heating the second mixture to form a dried mixture; grinding the second mixture into powder; and adding the powder to water or phosphate solution.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 29, 2011
    Applicant: CHUNG SHAN MEDICAL UNIVERSITY
    Inventor: SHINN JYH DING
  • Patent number: 8003766
    Abstract: This invention provides a monoclonal antibody specific to ochratoxin A and methods of assaying the level of ochratoxin A in food and feed.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: August 23, 2011
    Assignee: Chung Shan Medical University
    Inventor: Feng-Yih Yu
  • Publication number: 20110160260
    Abstract: The present invention provides a method of treating a neurodegenerative disorder in a patient, comprising administration to the patient a therapeutically effective amount of D-cycloserine and its derivatives.
    Type: Application
    Filed: November 5, 2010
    Publication date: June 30, 2011
    Applicants: Chung Shan Medical University, T.L. & G.M. Chemical Company
    Inventor: Ying-Jui Ho
  • Publication number: 20100266603
    Abstract: This invention provides a monoclonal antibody specific to ochratoxin A and methods of assaying the level of ochratoxin A in food and feed.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 21, 2010
    Applicant: CHUNG SHAN MEDICAL UNIVERSITY
    Inventor: Feng-Yih Yu
  • Publication number: 20100221368
    Abstract: A method for inhibition a cytokine, transgluaminase type 2 (TG2) or matrix metalloproteinase 9 (MMP-9) was provided.
    Type: Application
    Filed: February 27, 2009
    Publication date: September 2, 2010
    Applicant: CHUNG SHAN MEDICAL UNIVERSITY
    Inventor: Gregory J. Tsay
  • Publication number: 20100196514
    Abstract: The present invention provides a method for producing calcium silicate-based bone cement and a composition produced by the method. It further provides a novel composition for bone tissue repair.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 5, 2010
    Applicant: Chung Shan Medical University
    Inventor: Shinn-Jyh Ding
  • Patent number: 7662413
    Abstract: The present invention provides Nelumbo extract and a method thereof. The present invention further provides a composition comprising said extract and a method for treating subject suffering from breast cancer with the composition.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: February 16, 2010
    Assignees: Chung Shan Medical University
    Inventors: Chau-Jong Wang, Mong-Yuan Yang
  • Publication number: 20090299233
    Abstract: A device for measuring functional reach is disclosed, which comprises three parts: a support, one end thereof being attached to an object; a ruler, one end thereof being connected to the support; and a vernier, being connected to the ruler and moving on the ruler forward and backward. The invention is used for a functional evaluation test for measuring balance.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 3, 2009
    Applicant: CHUNG SHAN MEDICAL UNIVERSITY
    Inventors: Ching-Yi Wang, Yung-Wen Tang