Patents Assigned to Ciba-Geigy Corporation
  • Patent number: 4654302
    Abstract: The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof.The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: March 31, 1987
    Assignees: Ciba-Geigy Corporation, Plantorgan Werk Heinrich G.E. Christensen KG
    Inventors: Hans Fritz, Johannes Dodt, Ursula Seemuller, Ernst Fink
  • Patent number: 4654046
    Abstract: The invention relates to a thermosol pad-steam process for the continuous dyeing of cellulose/polyamide blends, which comprises impregnating said blends with a pad liquor which contains a non-ionic surfactant or a mixture of non-ionic surfactants, in addition to at least one vat dye and at least one metal complex dye and optionally further auxiliaries.This process is particularly suitable for dyeing large yardages.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: March 31, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Hellmut Felle
  • Patent number: 4652631
    Abstract: 1:2 chromium complex dyes suitable for dyeing nitrogen-containing materials and materials which contain hydroxyl groups, are disclosed which, in the form of the free acid, have the formula ##STR1## wherein each of the symbols independently has the following meanings: Z is nitrogen or a --CH,A is a benzene or naphthalene radical which carries the hydroxyl or carboxy ortho to the azo or azomethine group, or, if n is 1 and Z is a --CH, is the radical of an aliphatic, cycloaliphatic or aromatic aminocarboxylic acid,B and D are each independently of the other the radical of a coupling component which couples in the alpha- or o-position relative to X if Z is nitrogen, or the radical of an o-hydroxyaldehyde if Z is --CH,X is oxygen or --NR, wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl, with the proviso that X must be oxygen if Z is --CH,Y is a bridge member of the formula --SO.sub.2 or --SO.sub.2 --NR--SO.sub.2 --, wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl,n is 0 or 1, andp is an integer from 0 to 6.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Fabio Beffa, Ulrich Schlesinger
  • Patent number: 4652653
    Abstract: The reaction of 2-mercapto-benzothiazole or -benzimidazole with .alpha.,.beta.-unsaturated carboxylic acid derivatives in a strongly acid reaction medium gives compounds of the formula I ##STR1## in which X is sulfur or NH, each radical R independently of one another is H, alkyl, halogenalkyl, alkoxy, alkylthio, alkylsulfonyl, phenyl, alkylphenyl, phenylalkyl, cycloalkyl, halogen, NO.sub.2, CN, COOH, COOalkyl or a tertiary amino or carbamoyl group and R.sup.1, R.sup.2 and R.sup.3 independently of one another are H, alkyl, halogenalkyl, hydroxyalkyl, alkoxyalkyl unesterified or esterified carboxyl or carboxylalkyl, carbamyol, carbamyolalkyl or unsubstituted or substituted aryl or aralkyl, or R.sup.1 and R.sup.2 together are straight-chain or branched alkylene, which can be substituted by 1 or 2 carboxyl groups, R.sup.4 is unsubstituted or substituted amino, alkoxy, cycloalkoxy, aryloxy or aralkyloxy, or R.sup.2 and R.sup.4 together are CH.sub.2 --CO--O-- or --CH.sub.2 CO--NR.sup.5 -- or R.sup.3 and R.sup.
    Type: Grant
    Filed: May 7, 1985
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Marcus Baumann, Hans Bosshard, Hans Greuter
  • Patent number: 4652645
    Abstract: There are described novel cationic compounds of the formula ##STR1## wherein the symbols B and Z have the meanings defined in claim 1, and also processes for producing them and their use for dyeing and printing textile materials, such as polyacrylonitrile materials, leather and particularly paper, there being obtained greenish to reddish yellow dyeings which are distinguished by good general fastness properties.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Willy Stingelin, Jean-Marie Adam
  • Patent number: 4652648
    Abstract: Phosphonous acid monoester-monoamides of the formula ##STR1## in which n is 1, R.sub.1 is phenyl, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or alkyl, R.sub.5 is alkyl or cyclohexyl, R.sub.6 is 2,2,6,6-tetramethylpiperidin-4-yl or ##STR2## R.sub.3 may also be ##STR3## where X is methylene or isopropylidene and R.sub.6 is alkyl or cyclohexyl. Said compounds are suitable for protecting organic material from the harmful effect of heat, oxygen and light.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Michael Rasberger
  • Patent number: 4652269
    Abstract: Process for the continuous trichromatic dyeing of synthetic polyamide materials which comprises using at least one blue-dyeing fibre-reactive sulfo-containing anthraquinone dye together with at least one red-dyeing sulfo-containing azo dye and at least one yellow- or orange-dyeing sulfo-containing azo dye.The process according to the invention is suitable for the continuous dyeing of synthetic polyamide materials from aqueous liquors, producing level dyeings having good fastness properties, in particular good ozone fastness.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: March 24, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: James B. Bowles, Marshall White, Jr., Alois Puntener, Jean-Marie Adam, Peter Loew
  • Patent number: 4650867
    Abstract: A process for the preparation of 2,4,6-tris(aminophenylamino)triazines by condensing s-trichlorotriazine with 3 equivalents of a partially protected phenylenediamine and subsequently removing the protective groups, which process comprises carrying out the condensation in an anhydrous or water-containing aliphatic C.sub.2 -C.sub.4 alcohol, in the presence of an acid acceptor.2,4,6-Tris(aminophenylamino)triazines are important intermediates in dyestuff chemistry and are used, inter alia, for synthesizing textile, leather and paper dyes as well as pigments.
    Type: Grant
    Filed: March 19, 1986
    Date of Patent: March 17, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Roland Ronco, Willy Stingelin, Ernst Hanggi
  • Patent number: 4650870
    Abstract: Compounds of the formula (T).sub.g -E where T is a substituted 4-acyl-2-piperazinone group, g is 1 or 2 and E is a selected terminal or linking group, are effective light stabilizers for polyolefins and other organic polymers.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: March 17, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Thomas E. Conetta, Roger F. Malherbe, Roland A. E. Winter
  • Patent number: 4650861
    Abstract: This invention relates to novel azo dyes containing a 4-nitropyrazole azo moiety which may be substituted, for example, with an alkyl group which itself may be substituted, and an aniline coupler which may be substituted. The dyes produce bright red shades on hydrophobic textile fiber including polyesters, polyamides, and cellulose esters and show unexpected improvements in one or more of such properties as fastness to light, wash, ozone, gas such as oxides of nitrogen, perspiration, crock and sublimation, dyeability at desirable low energy levels to deep shades, build, pH stability, bloom resistance, leveling, migration, dye bath exhaustion, dye transfer, and the like.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: March 17, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Max A. Weaver, Gary T. Clark, Bill A. Eller
  • Patent number: 4650859
    Abstract: Chrome azo-azomethine dyes are disclosed which contain a benzthiazolylphenyl or stilbenyl radical bound via an aldehyde group to the aldehyde moiety of the azomethine dyes. The dyes are particularly useful for dyeing wool, polyamide and leather.
    Type: Grant
    Filed: December 31, 1984
    Date of Patent: March 17, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Fabio Beffa
  • Patent number: 4649181
    Abstract: Novel glycidyloxy diketones of the formula I ##STR1## (in which, for example, X is glycidyloxy, Y is H and R is 1,3-phenylene) are described.The compounds of the formula can be used together with customary curing agents and/or curing catalysts for the preparation of crosslinked (cured) products which have good thermal and mechanical properties.
    Type: Grant
    Filed: April 1, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Roland Darms, Charles E. Monnier
  • Patent number: 4649149
    Abstract: The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R.sub.1 represents an optionally 4-substituted piperazino group or a group of the formula R.sub.2 --alk--X.sub.2 --,R.sub.2 represents optionally esterified carboxy or represents hydroxymethyl,alk represents lower alkylene or lower alkylidene,X.sub.1 and X.sub.2, independently of one another, each represents oxygen or sulphur,Ph represents 1,2-phenylene optionally substituted as well as by the group R.sub.1 --C(.dbd.X.sub.1)--NH--,X.sub.3 represents oxygen, sulphur or optionally substituted imino, andR.sub.3 represents optionally fluorine-substituted lower alkyl or cycloalkyl,and their salts.The compounds of the formula I, which have proved to be excellent micro- and macrofilaricides and schistosomacides, are manufactured according to methods known per se.
    Type: Grant
    Filed: January 17, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Jacques Gallay, Ernst Schweizer
  • Patent number: 4648895
    Abstract: The invention relates to oxime ethers of the formula I ##STR1## wherein n is 1 or 2, each of R.sub.1 and R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl each of R.sub.3 and R.sub.4 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfonyl or nitro; each of R.sub.5 and R.sub.6 independently of the other is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, phenyl or phenyl which is substituted by halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, carboxyl, carbamoyl, C.sub. 1 -C.sub.4 alkylcarbamoyl, nitro or cyano, or R.sub.5 and R.sub.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Henry Martin, Urs Fricker
  • Patent number: 4649215
    Abstract: Novel asymmetric thioethers of the formula ##STR1## in which R.sup.1 represents a C.sub.1-3 -alkyl radical or a C.sub.1-3 -hydroxyalkyl radical of which the hydroxy group may be in esterified form,R.sup.2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms,R.sup.3 represents hydroxy, alkoxy or an optionally substituted amino group, and-X- represents a single bond, a methylene group or an optionally N-acylated primary aminomethylene groupwherein the O-atom of the hydroxy group is in the transconfiguration relative to the S-atom, are effective as leucotriene-antagonists since they eliminate the contractions of smooth muscles caused by leucotrienes and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.
    Type: Grant
    Filed: June 25, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas von Sprecher, Ivan Ernest, Alan J. Main, Andreas Beck
  • Patent number: 4648992
    Abstract: Novel phthalocyanine compounds are described, which have the formula ##STR1## in which MePc is the Si(IV)-, P(V)-, Ti(IV)-, Ge(IV)-, Cr(IV)-, Ga(III)-, Zr(IV)-, In(III)-, Sn(IV)- or Hf(IV)- phthalocyanine or -naphthalocyanine ring system, A is an anionic, nonionic or cationic group which imparts solubility in water, Z is the counter-ion to A, if the latter is an ionic group, and is 0 if A is a nonionic group, n is any desired number from 1 to 8, Y is a neutral substituent which does not impart solubility in water and p is any desired number from 0 to 6, it being possible for the groups AZ and Y present in the molecule to be identical or different in either case, and the sum of n+p being not more than 8 and MePc not being the Sn(IV)-phthalocyanine or Sn(IV)-naphthalocyanine ring system if p is 0 and if the only groups imparting water-solubility in the molecule are sulfo groups.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Gregor Graf, Gerd Holzle, Gerhard Reinert
  • Patent number: 4649062
    Abstract: Vehicles for ultraviolet radiation-curable ceramic enamels comprise (a) acrylate- or methacrylate-modified oligomers; (b) acrylate or methacrylate monomers, the functionality of (a) and (b) being selected to provide desired film and firing characteristics; (c) a combination of photoinitiators to provide a balance of surface and through cure; and an inhibitor to enhance shelf life. Printing media comprising pigmented frits and the vehicles are described, as are methods for their application to heat-resistant substrates, especially glass.
    Type: Grant
    Filed: April 25, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Raymond S. Kosiorek, Leslie R. Gatechair
  • Patent number: 4649221
    Abstract: Polyhydroxylamines are effective in stabilizing polyolefin compositions containing a stabilizer or mixture of stabilizers selected from the group consisting of the phenolic antioxidants, the hindered amine light stabilizers, the alkylated hydroxybenzoate light stabilizers, the ultraviolet light absorbers, the organic phosphorus compounds, the alkaline metal salts of fatty acids and the thiosynergists, against degradation upon high temperature extrusion, exposure to the combustion products of natural gas, gamma irradiation or upon storage for extended periods.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Ramanathan Ravichandran, Roger F. Malherbe, Raymond Seltzer
  • Patent number: 4648896
    Abstract: 2-Aryl-4,6-dihalopyrimidines of the formula I ##STR1## wherein Hal is halogen,E is unsubstituted or substituted phenyl, thienyl or furyl, andY is a group bound by way of nitrogen, oxygen or sulfur,are able as antidote or `safener` to protect cultivated plants against the phytotoxic action of herbicides. Cultivated plants concerned are particularly sorghum, cereals, maize, rice and soya bean, and herbicides concerned are chloroacetanilides or other herbicidally effective substances.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans-Georg Brunner
  • Patent number: 4648994
    Abstract: The invention discloses a process for the preparation of 1-amino-2-bromo-4-hydroxyanthraquinone by brominating 1-aminoanthraquinone in the 2- and 4-position in concentrated sulfuric acid and subsequently hydrolyzing the 1-amino-2,4-dibromoanthraquinone obtained as intermediate, which process comprises removing excess bromine and/or hydrobromic acid formed during the bromination from the reaction mixture and carrying out the hydrolysis at elevated temperature in the presence of an aldehyde. 1-Amino-2-bromo-4-hydroxyanthraquinone is an important intermediate for dyestuff synthesis and is used in particular for synthesizing anthraquinoid disperse dyes.
    Type: Grant
    Filed: January 24, 1986
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Muller, Hans Niederer, Othmar Hahn