Patents Assigned to Ciba-Geigy Ltd.
-
Patent number: 5919773Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.Type: GrantFiled: November 24, 1997Date of Patent: July 6, 1999Assignees: Isis Pharmaceuticals, Inc., Ciba-Geigy, Ltd.Inventors: Brett P. Monia, Pierre Martin, Karl-Heinz Altmann
-
Patent number: 5744362Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.Type: GrantFiled: June 5, 1995Date of Patent: April 28, 1998Assignees: Isis Pharmaceuticals, Inc., Ciba-Geigy, Ltd.Inventors: Brett P. Monia, Pierre Martin, Karl-Heinz Altmann
-
Patent number: 5359044Abstract: Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.Type: GrantFiled: December 13, 1991Date of Patent: October 25, 1994Assignees: ISIS Pharmaceuticals, Ciba-Geigy Ltd.Inventors: Phillip D. Cook, Gerhard Baschang
-
Patent number: 4866996Abstract: A sample metering valve for both liquid samples and slurry samples with entrained gas bubbles. The sample metering valve for liquids is comprised of a piston with sample chambers formed in the side thereof said piston moving freely into and out of a cylinder having an aperture matching the size of the piston. Sealing is provided by a seal which has no dead volume which cold flows under a spring bias to maintain the seal under various operating conditions. The sample metering valve for slurry samples includes a syringe embodiment having separately moving piston and valve in a cylinder. The syringe valve sucks up sample with a piston, isolates the sample with the valve and compresses the entrained gas bubbles with the piston. Another embodiment uses three, three way valves which are coupled to a pump and a means to compress the sample.Type: GrantFiled: June 16, 1987Date of Patent: September 19, 1989Assignee: Ciba-Geigy Ltd.Inventors: Andre J. Nohl, Vance J. Nau, Andre Metzger
-
Patent number: 4374914Abstract: Negative color images are produced by the silver dye bleach process, by exposure of a photographic silver dye bleach material, silver developing, dye bleaching, silver bleaching and fixing, the silver bleaching being optionally carried out simultaneously with the dye bleaching and/or the fixing, in a single treatment bath.Type: GrantFiled: July 13, 1981Date of Patent: February 22, 1983Assignee: Ciba-Geigy Ltd.Inventors: Herbert Mollet, Dieter Wyrsch
-
Patent number: 4369038Abstract: Auxiliary supports for dry transfer printing, which comprise dyestuffs of which the shades obtained by transfer at 205.degree. C. do not reach 60% of the intensity obtained by transfer at 235.degree. C.Type: GrantFiled: March 10, 1980Date of Patent: January 18, 1983Assignee: Ciba-Geigy Ltd.Inventor: Wolfgang Mehl
-
Patent number: 4369318Abstract: A process for the production of colored photographic images by the silver dye-bleach process by image-wise exposure and subsequent processing by developing the silver image, dye-bleaching and silver bleaching, it being possible, optionally, for the last two steps to be combined, silver fixing and washing, in which process dye-bleaching and/or silver bleaching is carried out in the presence of at least one bleach catalyst of the formula ##STR1## In the formula, A and B are in each case the non-metallic atoms necessary to complete a benzene or pyridine ring, R.sub.1 and R.sub.3 are each hydrogen, hydroxyl, halogen, alkyl, carboxyl, carbalkoxy, carbalkoxyalkoxy, --CH.sub.2 OH, --O(CH.sub.2).sub.n OH, --O(CH.sub.2).sub.2 O(CH.sub.2).sub.2 OH, --CH.sub.2 Cl, --CH.sub.2 Br, --NR.sub.5 R.sub.6, --CH.sub.2 NR.sub.5 R.sub.6, --O(CH.sub.2).sub.n NR.sub.5 R.sub.6, --CH.sub.2 SO.sub.3 M, --O(CH.sub.2).sub.n SO.sub.3 M or --SO.sub.3 M, R.sub.2 and R.sub.4 are each hydrogen, hydroxyl, alkyl or alkoxy and R.sub.5 and R.sub.Type: GrantFiled: July 17, 1980Date of Patent: January 18, 1983Assignee: Ciba-Geigy Ltd.Inventor: Gerald Jan
-
Patent number: 4369310Abstract: Dyestuffs of the general formula ##STR1## wherein A and B each represent a cyano, acyl or carbalkoxy group save that when A is cyano B cannot be cyano or carbalkoxy, or A and B form together with the carbon atom to which they are attached a carbocyclic or heterocyclic ring system, R.sub.1 is hydrogen, alkyl or alkoxy, R.sub.2 alkyl, R.sub.3, R.sub.4, R.sub.5 each are hydrogen, alkyl, carboxyalkyl, alkoxy-carbonyl-alkyl or aryl, or two of R.sub.3, R.sub.4 and R.sub.5 or all three R.sub.3, R.sub.4 and R.sub.5 may form together with the nitrogen atom to which they are bonded a ring system, Z is a linking group and X.sup..crclbar. an anion.The dyes can be bleached easily and they are suitable as antihalation or filter dyes in photographic materials.Type: GrantFiled: October 22, 1980Date of Patent: January 18, 1983Assignee: Ciba-Geigy Ltd.Inventor: Stephen R. Postle
-
Patent number: 4366232Abstract: A method for processing exposed and developed photographic silver dye-bleach materials, in which the exposed and developed material is treated with aqueous bleaching preparations which contain (a) an acid component, (b) a silver complexing agent, (c) one or more bleach catalysts, (d) optionally an antioxidant, (e) optionally a water-soluble oxidizing agent and (f) optionally a bleaching accelerator.A water-soluble and as a rule solid adduct of an acid amide or a lactam and a strong mineral acid is used as acid component (a).Type: GrantFiled: February 17, 1981Date of Patent: December 28, 1982Assignee: Ciba-Geigy Ltd.Inventors: Hansjorg Buser, Adolf Morand
-
Patent number: 4215782Abstract: A non-returnable container is made from at least two dish-shaped parts which have outward facing flanges joined together by a sealed seam and is intended for holding liquid and/or pasty, granular and/or powdery substances. The flanges of the dish-shaped parts, which are made of a metal-plastic composite are joined together by means of at least one sealed seam and are held in a bent position by means of a holding device.Type: GrantFiled: November 24, 1978Date of Patent: August 5, 1980Assignees: Swiss Aluminium Ltd., Ciba-Geigy Ltd.Inventors: Werner Festag, Hans-Ueli Muller, Oldrich Stanek, Peter Bahler