Abstract: A method for reducing or preventing the effects of inflammation arising from injured tissue, which method comprises the steps of:
a. bringing the injured tissue, or pre-injured tissue, into contact with a photosensitizing agent capable of penetrating into the tissue, resulting in the desired degree of biodistribution in less than one hour; and
b. exposing the tissue thus contacted to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to reduce or prevent inflammation in the exposed tissue, but not so long as to cause necrosis or erythema of the exposed tissue, or a pharmaceutical composition or an article for reducing or preventing the effects of inflammation arising from injured tissue.
The composition comprises:
a. from about 1 &mgr;/mL to about 2 mg/mL of a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution less than one hour; and
b. a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
October 2, 1997
Date of Patent:
August 14, 2001
Assignees:
QLT Inc., The University of British Columbia, CIBA Vision AG
Inventors:
Anna M. Richter, Julia G. Levy, Claude A. A. Hariton, Gustave Huber, William C. Stewart, Mario G. Fsadni