Patents Assigned to Ciblex Corporation
  • Modulators of leaderless protein export and methods for identifying and using the same
    Patent number: 6306613
    Abstract: Methods of modulating the export of a leaderless protein from a cell by contacting the cell with a compound that alters the binding of the leaderless protein and a transport molecule are provided. Transport molecules include gastrin binding protein/alpha subunit of mitochondrial fatty acid &bgr;-oxidation multienzyme complex (p70, GenBank Accession Nos. U04627/D16480), phosphotyrosine-independent ligand of the SH2 domain of p56lck (p62, GenBank Accession No. U46751), mitochondrial fatty acid &bgr;-oxidation trifunctional protein &bgr; subunit (TP-&bgr;) (p48, GenBank Accession No. D16481), actin related protein 3 (Arp3) (p48, GenBank Accession No. U29610), K-glypican (GenBank Accession No. X83577), tubulin (p50, GenBank Accession No. AF081484) and related polypeptides that are functionally equivalent in their role as leaderless protein trafficking components. Leaderless proteins include, for example, FGF-1, FGF-2, IL-1&agr;, IL-1&bgr;, CNTF, MIF, and HIV tat.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: October 23, 2001
    Assignee: Ciblex Corporation
    Inventors: Robert Z. Florkiewicz, Andrew Baird, Dale E. Warnock
  • Inhibitors of leaderless protein export
    Patent number: 6083706
    Abstract: Methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a compound that inhibits the binding of the leaderless protein and a transport molecule are provided. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta., CNTF and HIV-tat. These methods are useful in treatment of various conditions, including tumors and diabetes.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: July 4, 2000
    Assignee: Ciblex Corporation
    Inventors: Robert Z. Florkiewicz, Andrew Baird
  • Methods and compositions for regulating nuclear trafficking of proteins
    Patent number: 6028058
    Abstract: Methods are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29 kD, is identified as binding to and regulating nuclear localization of FGF-2. Inhibitors of the binding of the 29 kD component and FGF-2 are provided.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: February 22, 2000
    Assignee: Ciblex Corporation
    Inventor: Robert Z. Florkiewicz