Patents Assigned to Cibus US LLC
  • Patent number: 10676755
    Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are cassava plants, cells, and seeds comprising the mutated genes.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: June 9, 2020
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Tracey A. Lincoln, Gregory F. W. Gocal
  • Publication number: 20200123563
    Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are canola plants, cells, and seeds comprising the mutated genes.
    Type: Application
    Filed: December 27, 2019
    Publication date: April 23, 2020
    Applicant: Cibus US LLC
    Inventors: Christian Schopke, Gregory F. W. Gocal, Keith A. Walker, Peter R. Beetham
  • Patent number: 10612035
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: April 7, 2020
    Assignee: CIBUS US LLC
    Inventors: Greg F. W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Publication number: 20190264219
    Abstract: The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.
    Type: Application
    Filed: May 13, 2019
    Publication date: August 29, 2019
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel Joy SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Publication number: 20190249182
    Abstract: Provided herein include methods and compositions for making targeted changes to a DNA sequence. In various aspects and embodiments, methods and compositions for modifying a DNA sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided. In some aspects and embodiments the modification of DNA involves combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms, such as a DNA cutter.
    Type: Application
    Filed: September 16, 2016
    Publication date: August 15, 2019
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Patent number: 10287594
    Abstract: The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 14, 2019
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. Beetham, Gregory F. W. Gocal, Christian Schopke, Noel Joy Sauer, James Pearce, Rosa E. Segami, Jerry Mozoruk
  • Publication number: 20180355327
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 13, 2018
    Applicant: CIBUS US LLC
    Inventors: PETER R. BEETHAM, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Publication number: 20180327773
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 15, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Publication number: 20180327774
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Application
    Filed: July 19, 2018
    Publication date: November 15, 2018
    Applicants: CIBUS US LLC, INCIMA US LLC
    Inventors: Greg F.W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Publication number: 20180320190
    Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
    Type: Application
    Filed: April 30, 2018
    Publication date: November 8, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Patent number: 10035991
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: July 31, 2018
    Assignee: CIBUS US LLC
    Inventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Patent number: 9957515
    Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 1, 2018
    Assignees: CIBUS US LLC, CIBUS EUROPE, B.V.
    Inventors: Peter R. Beetham, Gregory F. W. Gocal, Christian Schopke, Noel Sauer, James Pearce, Rosa E. Segami, Jerry Mozoruk
  • Publication number: 20180051296
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Application
    Filed: October 16, 2017
    Publication date: February 22, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
  • Publication number: 20170369899
    Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are cassava plants, cells, and seeds comprising the mutated genes.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 28, 2017
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Tracey A. LINCOLN, Gregory F.W. GOCAL
  • Patent number: 9790515
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 17, 2017
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
  • Publication number: 20160145638
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 26, 2016
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
  • Publication number: 20130019349
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 17, 2013
    Applicants: INCIMA US LLC, CIBUS US LLC
    Inventors: CIBUS US LLC, INCIMA US LLC
  • Patent number: 8268622
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: September 18, 2012
    Assignees: Cibus US LLC, Incima US LLC
    Inventors: Greg F. W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Patent number: 8106259
    Abstract: Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germinating the microspores.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: January 31, 2012
    Assignee: Cibus US LLC
    Inventors: Peter R. Beetham, Keith A. Walker, Patricia L. Avissar