Patents Assigned to Ciclofilin Pharmaceuticals Corp.
  • Cyclosporine analogue molecules modified at amino acid 1 and 3
    Patent number: 9200038
    Abstract: Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: December 1, 2015
    Assignee: Ciclofilin Pharmaceuticals Corp.
    Inventors: Alexander Hegmans, Bruce W. Fenske, Dan J. Trepanier, Mark D. Abel, Daren R. Ure, Shin Sugiyama