Patents Assigned to Cilag AG
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Publication number: 20170022211Abstract: The present invention relates to an improved process for O-demethylating methoxy substituted morphinan-6-one derivatives using AlCl3 as a demethylating agent in a reaction-inert solvent having a water content ranging from 0.1% wt to 0.8% wt.Type: ApplicationFiled: April 7, 2015Publication date: January 26, 2017Applicant: CILAG AGInventors: Georg Ulrich WEIGL, Dominik Stefan STÄMPFLI, Nelli MAURER
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Patent number: 8318936Abstract: Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): wherein X? represents an anion other than the bromide anion, and R represents hydrogen or a leaving group, is dissolved or dispersed in a suitable polar solvent, the solution or dispersion is mixed with a compound containing bromide anions, and the resulting reaction mixture is stirred until N-methylnaltrexone bromide has formed and crystallized, wherein, in the case where R represents a leaving group, that group is removed during or after the reaction.Type: GrantFiled: May 14, 2008Date of Patent: November 27, 2012Assignee: Cilag AGInventors: Ulrich Weigl, Pascal Schär, Alfred Stutz
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Patent number: 8227609Abstract: A process for purifying plant extracts which consist essentially of noroxymorphone compounds and which comprise, as impurities, ?,?-unsaturated noroxymorphone compounds, by (a) converting the plant extract or the product of a subsequent stage in the synthesis of a selected noroxymorphone compound in a reaction which converts the hydroxyl groups present in the mixture to leaving groups of the formula —OR2 in which R2 is the introduced radical of the leaving group, (b) these leaving groups are optionally detached again, then (c) the resulting mixture is subjected to a selective hydrogenation, so that a saturated bond is formed in the ?,?-position of the unsaturated noroxymorphone compounds and any remaining leaving groups are each converted to a hydroxyl group and then optionally (d) the pure noroxymorphone compound is isolated; processing of the noroxymorphone purified in this way to naltrexone or naloxone or a salt of these compounds or a quaternary derivative of these compounds; pharmaceutical formulations cType: GrantFiled: February 9, 2006Date of Patent: July 24, 2012Assignee: CILAG AGInventors: Ulrich Weigl, Ulf Kötz, Ilia Freifeld
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Publication number: 20110178469Abstract: The present invention concerns an injection device with a housing adapted to receive a syringe having a discharge nozzle, the housing having an indicator opening. There is a trigger and a forward drive arranged to act upon the syringe on actuation of the trigger to advance the syringe from a retracted position to an extended position thereby discharging the contents of the syringe through the discharge nozzle. A support member is in contacting juxtaposition with the housing and a return drive is supported by the support member and arranged to act upon the syringe after the contents of the syringe has been discharged so that the syringe can be withdrawn from the extended position to the retracted position. Advantageously, the support member is arranged in the housing so that the second drive does not obscure an inspection of the contents of the syringe through the indicator opening. Hence, it can be clearly determined whether the contents of the syringe have been expelled from the syringe.Type: ApplicationFiled: May 27, 2005Publication date: July 21, 2011Applicant: CILAG AG INTERNATIONALInventors: David Johnston, Rosemary Habeshaw, Nigel Harrison
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Publication number: 20110144346Abstract: The invention relates to a method for producing N-phenyl-N-(4-piperidinyl)amide salts, particularly pharmaceutically tolerable addition salts of the compound Remifentanil, in that a compound of the formula (III) is reacted with an acrylic acid alkyl ester of the formula CH2?CH—C(O)—OR: where independently of each other R denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl, R1 denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl; and HX denotes an inorganic or organic acid, wherein the components are optionally reacted in the presence of a catalyst, preferably at a higher temperature, thereby obtaining the salt of the compound of formula (I).Type: ApplicationFiled: July 3, 2008Publication date: June 16, 2011Applicant: CILAG AGInventors: Oliver Flogel, Ulrich Weigl
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Publication number: 20100210675Abstract: Solvent-free crystalline polymorphic form of naltrexone, characterized in that it has the XRD data listed in Table 1, and a method for the preparation of this polymorphic form; and a method for converting this polymorphic form of naltrexone into a known polymorphic form of naltrexone.Type: ApplicationFiled: April 27, 2007Publication date: August 19, 2010Applicant: CILAG AGInventors: Ulrich Weigl, Ulf Költz
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Patent number: 7759364Abstract: The invention relates to non-hydrated fexofenadine hydrochloride which can be obtained from a fexofenadine base and hydrogen chloride, according to the reaction conditions, either in the form of a novel polymorph (“form A”), in an amorphous form, or in the form of a mixture of different polymorphs. Said novel polymorph (“form A”) can be used as a therapeutic active ingredient and can be processed to form a pharmaceutical containing the same and a pharmaceutically acceptable carrier. Said pharmaceutical is suitable for use as an antihistaminic agent, an antiallergic agent and/or a bronchodilating agent.Type: GrantFiled: January 17, 2002Date of Patent: July 20, 2010Assignee: Cilag AGInventor: Volker Kirsch
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Publication number: 20100168427Abstract: Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): wherein X? represents an anion other than the bromide anion, and R represents hydrogen or a leaving group, is dissolved or dispersed in a suitable polar solvent, the solution or dispersion is mixed with a compound containing bromide anions, and the resulting reaction mixture is stirred until N-methylnaltrexone bromide has formed and crystallised, wherein, in the case where R represents a leaving group, that group is removed during or after the reaction.Type: ApplicationFiled: May 14, 2008Publication date: July 1, 2010Applicant: CILAG AGInventors: Ulrich Weigl, Pascal Schär, Alfred Stutz
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Publication number: 20090054849Abstract: An injection device 110 is described having a housing 112 and a housing closure means 130. The injection device 110 houses a syringe 114 having a needle 118 which is sealed by a boot 120. The housing closure means 130 is arranged so that the boot 120 can be connected to the housing closure means 130 simply, but cannot be removed from the housing closure means 130. The housing 112 and housing closure means 130 are arranged so that upon rotation of the housing closure means 130, the housing closure means 130 is moved axially away from the housing 112 and the boot 120 is removed from the syringe 114. The injection device is simple to use and manufacture.Type: ApplicationFiled: May 27, 2005Publication date: February 26, 2009Applicant: CILAG AG INTERNATIONALInventors: Rosemary Burnell, Tim Barrow-Williams, Matthew Brady, Nigel Harrison
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Publication number: 20090054838Abstract: The invention concerns an injection device with a housing adapted to receive a syringe having a discharge nozzle and a plunger. There is a trigger and a drive arranged to act upon the plunger on actuation of the trigger to advance the syringe from a retracted position to an extended position through an opening in the housing. A locking mechanism is arranged in and moveable relative to the housing. The locking mechanism is engaged with the plunger when the syringe is not in its extended position and disengaged from the plunger when the syringe is in its extended position. This means that movement of the plunger relative to the syringe is prevented when, in use, the syringe is advanced from a retracted position to an extended position. Hence the contents of the syringe are not expelled from the syringe during advancement from the retracted position to the extended position. The contents are only expelled when the syringe reaches the extended position.Type: ApplicationFiled: May 27, 2005Publication date: February 26, 2009Applicant: CILAG AG INTERNATIONALInventor: Nigel Harrison
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Publication number: 20090012471Abstract: An injection device 110 is described having a housing 112 that receives a syringe 114 having a needle 118, wherein the syringe is supported in a syringe carrier 150. The syringe 114 and syringe carrier 150 are biased by a return spring 126 from an extended position in which the needle 118 extends from the housing 112 through an exit aperture 128 to a retracted position in which it does not. A drive spring 130 acts via a drive to advance the syringe 114 from its retracted position to its extended position and discharge its contents through the needle 118 and a return spring 126, brought into play when the drive has reached a nominal return position, restores the syringe 114 to its retracted position. The injection device is less prone to failure than prior art devices and is safer should failure occur.Type: ApplicationFiled: May 27, 2005Publication date: January 8, 2009Applicant: CILAG AG INTERNTIONALInventor: Nigel Harrison
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Publication number: 20090012470Abstract: An injection device (210) is described. A housing (212) receives a syringe and includes a return spring (226) for biasing the syringe from an extended position in which its needle (218) extends from the housing (212) to a retracted position in which the it does not. A drive spring (230) acts on a first drive element (232) and a second drive element (234) acts upon the syringe to advance it from its retracted position to its extended position and discharge its contents through the needle. The first drive element (232) is capable of movement relative to the second (234) once a nominal decoupling position has been reached. A release mechanism is activated when the first drive element (234) is further advanced to a nominal release position, to release the syringe (214) from the action of the drive spring (230), whereupon the return spring (226) restores the syringe (214) to its retracted position. A locking mechanism (337, 375) confines the returned syringe in its retracted position.Type: ApplicationFiled: May 27, 2005Publication date: January 8, 2009Applicant: CILAG AG INTERNTIONALInventor: Tim Barrow-Williams
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Publication number: 20060147527Abstract: This invention relates to an oral pharmaceutical preparation, suitable for dosing every 24 hours, comprising a substrate, which substrate comprises a pharmaceutically effective amount of tramadol or a salt thereof and a pharmaceutically effective amount of topiramate and wherein said substrate may be coated with a controlled release coating; said preparation having a specific dissolution rate in vitro.Type: ApplicationFiled: December 12, 2003Publication date: July 6, 2006Applicant: CILAG AGInventors: Dieter Bachmann, Reza Eivaskhani, Christian Braun, Rene Spycher, Brian Strong
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Patent number: 7034155Abstract: N-ethyl-N-[3-(3-cyanopyrazolo[1,5-a]pyrimidine-7-yl)phenyl]acetamide (Zaleplon) can be produced by condensing 3-(N-acetyl-N-ethyl-amino)-?-oxo-phenylpropanal sodium salt with 3-amino-4-cyanopyrazole. Said sodium salt can be produced by first treating 3-acetylamino-acetophenone with an alkali metal hydroxide, in particular with powdered potassium hydroxide and then with an ethylating reagent, in particular ethyl bromide and the N-(3-acetylphenyl)-N-ethyl-acetamide that is obtained is reacted with a formic acid alkyl ester in the presence of an alkali metal alkanolate, in particular in the presence of sodium ethanolate. Zaleplon is the active ingredient of the soporific licensed under the trade name Sonata®.Type: GrantFiled: January 17, 2003Date of Patent: April 25, 2006Assignee: Cilag AGInventor: Stefan Horns
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Patent number: 7005531Abstract: The present invention refers to a method for making iron(III)gluconate complex, preferably alkali iron(III)gluconate complex. The method includes the following steps: (i) mixing a water soluble iron(III)salt in aqueous solution, simultaneously or in any desired sequence, with a member selected from gluconic acid, a water soluble salt of gluconic acid and combinations thereof, and a member selected from an alkali hydroxide, an alkali carbonate, an alkali hydrogen carbonate and combinations thereof, so that the reaction mixture has an acid value (pH-value) within the range of from 7.0 to 12, provided that when alkali hydroxide is used, gluconic acid or a water soluble salt of gluconic acid is provided at the beginning of the reaction or is added to the reaction mixture simultaneously with the alkali hydroxide; (ii) heating the reaction mixture until the iron(III)gluconate complex has formed; and (iii) adding an organic solvent which is miscible with water until the iron(III)gluconate complex is precipitated.Type: GrantFiled: November 18, 2004Date of Patent: February 28, 2006Assignee: Cilag AGInventors: Michael Justus, Rolf Hänseler
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Patent number: 6841679Abstract: A compound of the general formula (1), in which: Y denotes hydrogen, a halogen or a C1-4 alkyl group; X1 and X2 denote, independently of each other, hydrogen, a halogen, a C1-4 alkoxy, C1-6 alkyl, CF3, CH3S CH3SO2 or NO2 group; and R1 and R2 denote independently of each other, hydrogen or a C1-5 alkyl group, with the proviso that R1 and R2 do not both denote hydrogen, or a salt thereof, and is prepared by a multi-step process, the last step of which comprises reducing a compound of the general formula (6), in which Y, X1, X2, R1 and R2 are as defined above with an appropriate reducing agent, such as Zn, and, if desired, converting the compound of formula (1) thus obtained, into a salt. The products of this process are known to have useful pharmacological properties, e.g. as anxiolytics.Type: GrantFiled: August 17, 2001Date of Patent: January 11, 2005Assignee: Cilag AGInventors: Heidedore Hisabeth Rey-Papina, Armin Rossler, Giusep Derungs, Jae Kyoung Pak, Max Rey
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Patent number: 6753349Abstract: The invention relates to a method for producing compounds which contain at least one molecule valproic acid salt and at least one molecule valproic acid. The valproic acid salt represents alkali or alkaline earth salt. Valproic acid is directly converted with the calculated amount of the corresponding alkali carbonate or earth alkaline carbonate and/or the calculated amount of the corresponding alkali bicarbonate or earth alkaline bicarbonate without adding a solvent and at a temperature that is higher than the melting temperature of valproic acid.Type: GrantFiled: July 16, 2002Date of Patent: June 22, 2004Assignee: Cilag AGInventor: Christian Weh
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Patent number: 6645522Abstract: The present invention relates to a liposome based formulation of erythropoietin comprising: (a) an effective amount of an erythropoietin; (b) a lipidic phase comprising: (i) lecithin or hydrogenated lecithin; (ii) optionally, a charged electropositive or electronegative lipid compound; and (iii) cholesterol or a derivative thereof selected from cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols), and organic acid derivatives of cholesterols; and (c) a phosphate buffer. The liposome based parenteral dosage form of the invention is prepared by means of an ethanol injection technique. The composition avoids the need for use of human serum albumin and exhibits superior stability.Type: GrantFiled: February 18, 1999Date of Patent: November 11, 2003Assignee: Cilag AGInventors: Rainer Naeff, Sandro Delmenico, André Wetter, Frank-Ulrich Floether
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Patent number: 5834016Abstract: A liposome-based formulation with good skin penetration of the effective substance, particularly calcitriol, is described. This formulation is well suited for the treatment of psoriasis.Type: GrantFiled: March 6, 1997Date of Patent: November 10, 1998Assignee: Cilag AGInventors: Rainer Naeff, Sandro Delmenico, Rene Spycher, Mike Corbo, Frank Flother
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Patent number: 4698359Abstract: A medicated suppository for use in the vaginal or rectal cavity comprising a medicament, a mixture of triglycerides of fatty acids, a gel forming agent and a gel dispersing agent is described.Type: GrantFiled: May 31, 1985Date of Patent: October 6, 1987Assignee: Cilag, AGInventors: Roland R. Niederer, Hans W. Zulliger