Patents Assigned to Cilag Ltd.
  • Patent number: 7923558
    Abstract: The invention relates to a method for obtaining pure tetrahydrocannabinol from reaction mixtures containing tetrahydrocannabinol compounds or from raw products containing tetrahydrocannabinol compounds. According to said method, the tetrahydrocannabinol compounds in the reaction mixture or in the raw product are converted into crystallisable derivatives, preferably using a suitable solvent, said derivatives are then crystallised and isolated, and the pure tetrahydrocannabinol compounds are then obtained from the crystallised derivatives. The invention also related to the use of compounds produced in this way for the production of a medicament for human therapy, and to the medicaments thus produced.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: April 12, 2011
    Assignee: Cilag Ltd.
    Inventors: Enver Arslantas, Ulrich Weigl
  • Patent number: 7915421
    Abstract: Method for preparing (S)(+)phenyl acetic acid derivatives having the general formula (I): wherein R1 is a linear or branched alkyl group with 1-6 carbon atoms or substituted benzyl group, and R2 is methyl, ethyl or propyl group said method, characterised in that a compound of the general formula (II): wherein R1 is as given above, and R3 is a nucleofuge, or a suitable salt of a compound of the general formula (II) is reacted with a compound having the general formula (III): wherein R2 is as given above, and R4 is hydrogen or a nucleofuge that can be removed hydrolytically, and the protective group R4 that may be present, may be subsequently removed hydrolytically.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: March 29, 2011
    Assignee: Cilag Ltd.
    Inventors: Rainer Heck, Michael Justus, Roland Müller, Thomas Otten, Martin Rettig
  • Publication number: 20070299260
    Abstract: The invention concerns a method for preparing optionally substituted 3-indolcarboxylic acid esters, with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the optionally substituted 3-indolcarboxylic acid is converted by means of a suitable halogenating agent, into corresponding acid halide, preferably corresponding acid chloride, and the latter is transformed with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the entire reaction occurs in acid medium with a maximum pH of 7.
    Type: Application
    Filed: November 25, 2004
    Publication date: December 27, 2007
    Applicant: CILAG LTD.
    Inventors: Hans-Ulrich Bichsel, Vit Lellek
  • Patent number: 7235666
    Abstract: Phosphoric acid diester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl esters, both of whose ester groups can be selectively cleaved, are obtained by converting 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione to an alkylsulfonate or arylsulfonate and reacting this with a phosphoric acid diester whose ester groups can be selectively cleaved from the reaction product. The two ester groups can be selectively cleaved from the phosphoric acid diesters obtained and the resulting product can be converted to 5,5-diphenyl-3-[(phosphonooxy)methyl]imidazolidine-2,4-dione disodium salt. The latter is an anticonvulsive, antiepileptic and antiarrhythmic known under the abbreviated name of sodium fosphenytoin.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: June 26, 2007
    Assignee: Cilag Ltd.
    Inventor: Volker Kirsch