Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: Provided herein is a method of diagnosing and treating a subject suffering from atopic dermatitis (AD), the method comprising: (a) obtaining a skin biopsy from a subject suspected of suffering from AD; (b) determining a level of RNA expression in the skin biopsy of genes selected from the 89ADGES gene panel; (c) comparing the determined level of RNA expression of the selected genes to the level of RNA expression of the selected genes in a reference sample comprising RNA expression products from normal healthy skin cells; (d) diagnosing the subject as suffering from AD when specific genes are up-regulated compared to the reference sample and when specific genes are down-regulated compared to the reference sample; and (e) treating the subject with a therapy effective for the treatment of AD. Methods of managing treatment of a subject suffering from AD are also provided.

Abstract: A current system allows data-driven hypothesis generation to identify therapeutic candidates for a disease phenotype treatment by identifying drugs and clinical indications associated with lower occurrences of disease-associated phenotype(s) by a drug/drug class. A current system may include a pharmaceutical hierarchical ontology; a phenotype hierarchical ontology; a record database comprising clinical event records; a database mining engine; and a mapping engine. The database mining engine may iteratively progress through a portion of the pharmacological hierarchical ontology and phenotype hierarchical ontology to iteratively select pairs of cohort entries from each ontology; and for each pair of cohort entries, query the clinical record database for matching records.

Abstract: Provided herein are methods and kits related to use of vanin-1 (VNN1) expression for assessing responsiveness to steroid treatment in subjects with asthma and for treating subjects with asthma.

Abstract: Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

Abstract: Diagnostic methods for assessing risk of or presence of inflammatory bowel disease in a patient based on glycosyltransferase or histo-blood group antigen signatures or a combination thereof. Also disclosed herein are prognostic methods for monitoring inflammatory bowel disease progression in a patient.

Abstract: Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In particular, certain microRNAs and messenger RNAs are useful indicators of response to NSAID chemoprevention and therapy of patients having Lynch syndrome or hereditary non-polyposis colorectal cancer.

Abstract: The present invention provides methods of inhibiting angiogenesis in a malignant tumor, inhibiting metastasis of a malignant tumor and of inhibiting transformation of a benign tumor to a malignant tumor. The present invention also provides assays for identifying inhibitors of angiogenesis in a malignant tumor, inhibitors of metastasis of a malignant tumor and of inhibitors of transformation of a benign tumor to a malignant tumor.

Abstract: A system and a method is disclosed for consistently and verifiably optimizing computed tomography (CT) radiation dose in the clinical setting. Mathematical models allow for estimation of patient size, image noise, size-specific radiation dose, and image quality targets based on digital image data and radiologists preferences. A prediction model estimates the scanner's tube current modulation and predicts image noise and size-specific radiation dose over a range of patient sizes. An optimization model calculates specific scanner settings needed to attain target image quality at the minimum radiation dose possible. An automated system processes the image and dose data according to the mathematical models and stores and displays the information, enabling verification and ongoing monitoring of consistent dose optimization.

Abstract: The present invention provides methods for differentiating a pediatric subject with pediatric septic shock from a healthy pediatric subject or one having sudden inflammatory response syndrome (SIRS). Also provided is a method of predicting pediatric septic shock mortality in a pediatric septic shock patient.

Abstract: Methods of treating solid organ injuries using compounds that enhance Wnt signalling are described.

Abstract: An instrument guide apparatus for use with a surgical or other guided intervention of a patient utilizing a guided instrument is disclosed. The instrument guide apparatus includes at least two line lasers mounted above the patient and generating intersecting planar laser lines along an instrument axis of entry in three-dimensional space above the patient. In an embodiment, the instrument axis of entry in three dimensional space above the patient is received from an imaging apparatus imaging the patient's body at least along a portion of the instrument's axis of entry into the patient. In an embodiment, the instrument axis of entry in three-dimensional space above the patient is a line-of-site for a camera mounted above the patient and controlled by the imaging apparatus.

Abstract: Methods, systems, devices and/or apparatus related to predicting availability of medical facility beds. Specifically, the disclosed methods, systems, devices and/or apparatus relate to determining which beds in the medical facility are available or unavailable at specific time periods (including past, present and/or future time periods).

Abstract: Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

Abstract: The present invention refers to muteins of the C5a anaphylatoxin (C5a) which are C5a receptor antagonists, to nucleic acid molecules comprising a nucleotide sequence encoding such muteins of C5a anaphylatoxin, to host cells containing a nucleic acid molecule comprising a nucleotide sequence encoding such muteins of the C5a anaphylatoxin as well as to a pharmaceutical composition comprising a mutein of the C5a anaphylatoxin acting as a C5a receptor antagonists. A mutein of the invention is a C5a receptor antagonist wherein the amino acid residue naturally occurring at sequence position 69 is mutated.

Abstract: The present invention provides an automated triage system performs a computerized method that includes the steps of: (1) for plurality of patients, gathering medical factor(s) associated with each patient's medical condition, where the medical condition may be (a) a type of injury, (b) a symptom, (c) a condition of a patient, and/or (d) a demographic statistic of the patient; (2) for the same plurality of patients, gathering subjective perception(s) associated with each patient's medical condition, which may be (a) the anxiety of the patient, (b) the anxiety/concern of the referring physician, and/or (c) the anxiety of the reviewing attendee; and (3) ordering, by a computerized algorithm, the plurality of patients for medical treatment and/or medical assessment, based upon the medical factors and subjective perceptions gathered for each of the plurality of patients.

Abstract: Systems and methods for debulking visceral fat within a subject, include: providing a focused ultrasound transducer configured to focus ultrasonic power at a focal spot; positioning the focused ultrasound transducer with respect to the subject so that the focused ultrasound transducer is enabled to transfer ultrasonic power into the subject; locating the focal spot of the focused ultrasound transducer with respect to at least one target region containing visceral fat within the subject; and debulking visceral fat within the target region by applying ultrasonic energy from the focused ultrasound transducer with sufficient power to cause the death of visceral fat tissue within the target region.

Abstract: Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (BPD).

Abstract: Methods of treating solid organ injuries using compounds that enhance Wnt signalling are described.

Abstract: A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being cared-for or treated according to the patient's true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject's biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject's recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data.