Patents Assigned to Cincinnati
  • Hydrogen peroxide-activated compounds as selective anti-cancer therapeutics
    Patent number: 10071954
    Abstract: Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of hydrogen peroxide and are therefore selective anti-cancer therapeutics for cancers associated with elevated reactive oxygen species (ROS). Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: September 11, 2018
    Assignee: University of Cincinnati
    Inventors: Edward J. Merino, James Mulloy, Anish K. Vadukoot, Mark Wunderlich, Safnas F. Abdulsalam
  • Therapeutic uses of CD137pos regulatory T cells
    Patent number: 10071134
    Abstract: A method for treating or preventing a T-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble CD137 or CD137pos regulatory T cells. Also provided are pharmaceutical compositions for treating or preventing T-cell-mediated autoimmune diseases, the pharmaceutical compositions including a therapeutically effective amount of soluble CD137 or CD137pos regulatory T cells and a pharmaceutically-acceptable carrier.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: September 11, 2018
    Assignee: University of Cincinnati
    Inventors: William Ridgway, David Erwin Adams, Kritika Kachapati
  • Silver nanoparticle-enhanced photosensitizers
    Patent number: 9999225
    Abstract: The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). A method of killing bacteria may include contacting bacteria with a nanostructure (10) including a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16) to form a blend and exposing the blend to light.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 19, 2018
    Assignee: University Of Cincinnati
    Inventors: Peng Zhang, Bo Hu, Hong Tang
  • Microfluidic methods for passive separation of cells and particles
    Patent number: 9987632
    Abstract: A method of separating a plurality of particles (14) from a portion of fluid, comprising directing the plurality of particles (14) into a microchannel (12). A first portion (16) of particles (14) is focused into an equilibrium position in the microchannel (12). The focused first portion (16) is directed into a first outlet (18) aligned with the equilibrium position. A portion of the fluid is directed into one or more outlets (20, 22). A microfluidic device (10) for separating a plurality of particles (14) from a portion of fluid, comprising a microchannel (12) having a first aspect ratio and a length L, thereby focusing the particles (14) directed therein into an equilibrium position in the microchannel, wherein at least a first portion (16) of the particles (14) focuses at distance X from a beginning of the microchannel (12).
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: June 5, 2018
    Assignee: University of Cincinnati
    Inventors: Ian Papautsky, Jian Zhou
  • Device for producing plastic tubes
    Patent number: 9969114
    Abstract: An apparatus produces plastic tubes by extrusion with an extruder, a pipehead being attached to the extruder in production direction, having a base material with at least one mandrel and a sleeve, a melt channel between the mandrel and the sleeve, the melt channel shaped to aid flow in production direction at least at the mandrel's end and at the sleeve's end, the mandrel and sleeve being adjustable backwards and forward relatively to one another, the outer surface of the mandrel and/or the inner surface of the sleeve at least partially has a material that allows for a higher sliding quality than the base material. The outer and/or the inner surface (i) has a coating either unvaried, or whose sliding quality constantly improves, or whose sliding quality alternately improves and worsens, in the production direction, or (ii) is partially coated, or (iii) the mandrel and/or sleeve fronts are coated.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: May 15, 2018
    Assignee: BATTENFELD-CINCINNATI GERMANY GMBH
    Inventors: Henning Stieglitz, Heinrich Dohmann
  • Device for cutting extruded plastics profiles to length
    Patent number: 9969096
    Abstract: A device for cutting a preferably thick-walled extruded pipe to length, has at least one cutting tool and a receiving unit for the cutting tool, wherein the cutting tool is movable radially with respect to the extension axis and is rotatable by a further means about the pipe to be cut to length, in order to cut the pipe to length. The receiving unit preferably has two toothed rods arranged in a block, wherein the first toothed rod is movable back and forth axially and the second toothed rod radially with respect to the extension axis, the axial movement is converted into a radial movement, and the cutting tool is arranged on the second toothed rod.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: May 15, 2018
    Assignee: BATTENFELD-CINCINNATI GERMANY GMBH
    Inventors: Joerg Droege, Christian von Hippel
  • Compositions and methods for treating cocaine-related disorders
    Patent number: 9957332
    Abstract: A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In a specific embodiment, the antibody is a monoclonal antibody comprising a murine lambda light chain variable region, a human gamma heavy chain variable region, and a human kappa or lambda light chain constant region.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 1, 2018
    Assignee: University of Cincinnati
    Inventors: Andrew B. Norman, William J. Ball
  • Method of treating diabetes using non-glycosylated apolipoprotein A-IV
    Patent number: 9951120
    Abstract: Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed, wherein the methods and compositions of the invention are based on the use of non-glycosylated apolipoprotein A-IV produced by a protein expression system, such as a bacterial expression system. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof based on administering non-glycosylated apolipoprotein A-IV produced by a protein expression system.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: April 24, 2018
    Assignee: University of Cincinnati
    Inventors: Patrick Tso, Fei Wang, Sean Davidson
  • Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
    Patent number: 9951024
    Abstract: Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: April 24, 2018
    Assignees: Children's Hospital Medical Center, Univeristy of Cincinnati
    Inventors: Yi Zheng, Matthew Wortman
  • Compositions and Methods for Treating Cocaine-Related Disorders
    Publication number: 20180100025
    Abstract: A method of treating a cocaine-related disorder in an individual is provided, the method including administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In a specific embodiment, the antibody is a monoclonal antibody comprising a murine lambda light chain variable region, a human gamma heavy chain variable region, and a human kappa or lambda light chain constant region.
    Type: Application
    Filed: March 13, 2014
    Publication date: April 12, 2018
    Applicant: UNIVERSITY OF CINCINNATI
    Inventors: Andrew B. Norman, William J. Ball, JR.
  • Hyperspectral optical element for monolithic detectors
    Patent number: 9939321
    Abstract: A hyperspectral optical element for monolithic detectors is provided. In one embodiment, for example a hyperspectral optical element includes a faceplate layer adapted to be mounted on top of a monolithic detector. The faceplate layer comprises a reflective inner surface. A notched layer includes a plurality of notched surfaces and is mounted to the faceplate layer. The notched surfaces oppose the reflective inner surface of the faceplate and define a plurality of variable depth cavities between the reflective inner surface of the faceplate layer and the plurality of notched surfaces of the notched layer. The faceplate layer and the notched layer are substantially transparent to a received signal and the plurality of variable depth cavities provides resonant cavities for one or more wavelengths of the received signal.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 10, 2018
    Assignee: L-3 COMMUNICATIONS CINCINNATI ELECTRONICS CORPORATION
    Inventors: Michael Bartosewcz, Tristan Van Hoorebeke, Phillip Michael Henry, Anthony William Sarto
  • Stimulation via TLR4/MD-2 to reverse type 1 diabetes
    Patent number: 9938348
    Abstract: Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed methods and compositions. Also disclosed are methods of restoring adaptive immune T cell tolerance, treating pernicious insulitis, improving immune tolerance, and treating autoimmune diseases using the disclosed methods and compositions.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: April 10, 2018
    Assignee: University of Cincinnati
    Inventor: William Ridgway
  • Device for guiding and/or forming an extruded strand of plastic and process for coating a flat material
    Patent number: 9937517
    Abstract: A device for guiding and/or forming a plastics profile includes a region of alterable cross-section formed by a wound flat element. The wound flat element overlaps in a region and is in close mutual contact in the overlapping region. The wound flat element includes a flexible and resiliently deformable coating thereon. A device is provided for altering the region of alterable cross-section.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 10, 2018
    Assignee: BATTENFELD-CINCINNATI GERMANY GMBH
    Inventors: Heinrich Dohmann, Thomas Gesper
  • Compositions and methods for treating bacterial infection
    Patent number: 9925206
    Abstract: Compositions and methods of utilizing the same are provided for treating bacterial infections. The compositions comprise acidified nitrite in combination with an iron chelator and an antibiotic. The compositions of the present invention are effective at treating bacterial infections with minimal to no side effects. Surprisingly, the combination of these three agents has a synergistic effect, which advantageously permits a lower dose of one or more of the active agents (e.g., the antibiotic).
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 27, 2018
    Assignee: UNIVERSITY OF CINCINNATI
    Inventor: Daniel J. Hassett
  • Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices
    Patent number: 9920113
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: March 20, 2018
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATI, YALE UNIVERSITY
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • Optical sensor based on PFSI membrane comprising associated benzene-1,3-diol for detecting target compounds, and method thereof
    Patent number: 9921167
    Abstract: An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition metal-free dye component, wherein exposure of the optical sensor to a specific environmental condition produces a color shift on the optical sensor.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 20, 2018
    Assignee: University of Cincinnati
    Inventors: Anastasios Angelopoulos, Subasri M Ayyadurai, Jonathan A. Bernstein, Daniel S. Kanter
  • Tunneling Barrier Infrared Detector Devices
    Publication number: 20180076345
    Abstract: Embodiments of the present disclosure are directed to infrared detector devices incorporating a tunneling structure. In one embodiment, an infrared detector device includes a first contact layer, an absorber layer adjacent to the first contact layer, and a tunneling structure including a barrier layer adjacent to the absorber layer and a second contact layer adjacent to the barrier layer. The barrier layer has a tailored valence band offset such that a valence band offset of the barrier layer at the interface between the absorber layer and the barrier layer is substantially aligned with the valence band offset of the absorber layer, and the valence band offset of the barrier layer at the interface between the barrier layer and the second contact layer is above a conduction band offset of the second contact layer.
    Type: Application
    Filed: November 9, 2017
    Publication date: March 15, 2018
    Applicant: L-3 Communications Cincinnati Electronics Corporation
    Inventor: Yajun Wei
  • Device for cutting extruded plastic profiles to length
    Patent number: 9914231
    Abstract: A device for cutting a preferably thick-walled, extruded pipe to length, has at least one cutting tool and a receiving unit for the cutting tool. The cutting tool is radially movable in relation to the extrusion axis, is rotatable via a further component about the pipe to be cut to length, in order to cut the pipe to length, and is in operative connection with a ring element, which ring element can be moved via an axial drive, and the depth of penetration of the cutting tool and the path of movement can be defined using an adjustment unit. The depth of penetration of the cutting tool and the path of movement can be defined via the axial drive, wherein toothed rails can be moved more or less in order to achieve the desired depth of penetration.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: March 13, 2018
    Assignee: BATTENFELD-CINCINNATI GERMANY GMBH
    Inventors: Joerg Droege, Christian von Hippel
  • Tunneling Barrier Infrared Detector Devices
    Publication number: 20180069140
    Abstract: Embodiments of the present disclosure are directed to infrared detector devices incorporating a tunneling structure. In one embodiment, an infrared detector device includes a first contact layer, an absorber layer adjacent to the first contact layer, and a tunneling structure including a barrier layer adjacent to the absorber layer and a second contact layer adjacent to the barrier layer. The barrier layer has a tailored valence band offset such that a valence band offset of the barrier layer at the interface between the absorber layer and the barrier layer is substantially aligned with the valence band offset of the absorber layer, and the valence band offset of the barrier layer at the interface between the barrier layer and the second contact layer is above a conduction band offset of the second contact layer.
    Type: Application
    Filed: November 9, 2017
    Publication date: March 8, 2018
    Applicant: L-3 Communications Cincinnati Electronics Corporation
    Inventor: Yajun Wei
  • Inorganic microporous ion exchange membranes for redox flow batteries
    Patent number: 9911985
    Abstract: A composite structure comprising a layer of zeolite having a high silica to alumina ratio supported on a support layer acts as a separator in a redox flow battery. The zeolite can be either supported on a rigid substrate, such as alumina, or a flexible substrate, such as a polymeric film. The polymeric film, in particular, can be an ion exchange membrane such as Nafion. The zeolite layer with a high silica to aluminum ratio provides a long-lasting separator for redox flow batteries.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 6, 2018
    Assignees: University Of Cincinnati, Bettergy Corp.
    Inventors: Junhang Dong, Zhi Xu, Lin-Feng Li, Ruidong Yang