Abstract: A method for the formation of intramolecular amide bonds by the action of cyanogen, under mild reaction conditions, in the preparation of cyclic amides, including lactams, in biologically active compounds. A compound containing at least one carboxylic acid group and at least one primary or secondary amino group is reacted with cyanogen to form an intramolecular amide bond. The method has utility in the synthesis of B-lactam antibiotics, such as penicillins, cephalosporins, and their derivatives, in enzyme modification, in cyclization of peptides, and in covalent cross-linking of proteins.

Abstract: A fiber placement machine has a head for controlling fiber tows running from an upstream supply creel to a downstream work laydown zone, and the head includes a bracket supporting a presser member which impresses and compacts the fiber against a workpiece. The head includes a relatively rigid fiber guide assembly and a drive for moving the fiber guide to an advanced position near the presser member and a retracted position away from the presser member. In the advanced position, fiber tows run uninhibited through channels in the fiber guide. However, when it is desired to cut the fibers, the fiber guide is run to the retracted position, at which point the guide is clamped to the incoming fiber tows. After the exiting cut fiber has been laid down on the workpiece by the presser member, the incoming fibers may be restarted by driving the fiber guide and its clamped fiber tow to an advanced position where the fiber tow end may be grabbed in the nip formed between the presser member and the workpiece.

Abstract: A method and apparatus for controlling the hydraulic pressure in an hydraulic clamping cylinder to correspond with a desired clamping force and to compensate for overshoot of the hydraulic pressure caused by time delays in operating the components in the hydraulic circuit. The control arrangement involves the sensing of the actual hydraulic pressure during the clamp force maintenance portion of a clamping cycle and comparing the actual pressure with a desired pressure to provide a correction signal to be utilized to control the operation of the hydraulic system during the next succeeding cycle so that the actual hydraulic pressure during the clamp maintenance portion of the clamping cycle during the next succeeding cycle results in a clamping force that is closer to the desired clamping force.

Abstract: A short monopole RF antenna tuned over a predetermined RF frequency band in response to binary control signals includes a conductive tubular radiating element extending generally at right angles to a ground plane on which the antenna is mounted. A conductive top load inductively coupled to the element extends approximately parallel to the ground plane so that stray capacitance subsists between the ground plane and top load. The antenna is tuned in response to the control signals to a frequency in the band by selectively short-circuiting different plural series-connected inductors in proximity with the top load. Plural leads extend through the interior of the tubular element between a source of the control signals and switches for selectively short circuiting the inductors. The inductors are electrical conductors in a tube-like structure. The leads extend through the interior of the tube-like structure. Electrical conductors in the tube-like structure are in a return path to the control signal source.

Abstract: A longitudinal conveying system for mechanically feeding one or more workpieces to a predetermined loading position, comprising a pair of spaced, parallel longitudinal workpiece supports, with each such supports including an upper support face and having a distal end and a proximal end. The predetermined loading position is located adjacent the proximal end of the workpiece supports, and a longitudinal conveying beam is moveably located intermediate the workpiece supports. The conveying beam has an upper surface for supporting one or more workpieces. Driving apparatus for moving the conveying beam in an upward direction, a forward conveying direction toward the proximal end, a downward direction, and a backward direction is provided for enabling the conveying beam to lift workpieces from the workpiece supports for movement toward the proximal end.

Abstract: A durable wooden golf club head is disclosed having a hitting face with a non-wooden durable insert that is screw threaded into the head whereby the wooden head and face are protected from deterioration upon impact by a golf ball. The wooden head is made by screw threading the insert into a matching socket and causing a hardenable liquid adhesive to hydraulically penetrate the head from the socket to the surface of the wood whereby the head provides a solid golf ball hitting body.

Abstract: A sterile pyrogen free Re.sup.196 or Re.sup.188 radiopharmaceutical is prepared by reducing radioactive perrhenate in the presence of a bone seeking ligand to form a solution including complexed Re-ligand compound together with impurities such as uncomplexed perrhenate, ReO.sub.2 and free ligand. The radiopharmaceutical is obtained by a low pressure purification method. The solution is added to a separation column, preferably an ion exchange column, and a first portion is eluted and discarded. The radiopharmaceutical is collected in a second eluted portion defined as having 25-85% of the activity of the Re on the column, less than 10% unligated perrhenate and less than 1% ReO.sub.2. This can be used as is to image and treat metastatic bone leasions. A simple kit is also disclosed.

Abstract: A solid state microanemometer with improved sensitivity and response time is micromachined out of a single deep level doped semiconductor crystal and includes four corner supports interconnected to four spanning members which form the resistor legs of a Wheatstone bridge. The bottom of the supports are electrostatically bonded to a glass plate, thus thermally isolating the resistor legs a predetermined distance above the top surface of the plate and electrically isolating the supports. Electrically conductive material deposited on the four corner supports provides electrical contacts which enable a voltage to be applied across the resistor legs. Preferably, an n.sup.+ material is diffused into the region of the crystal located beneath the electrically conductive material, and the exposed surfaces of the crystal are sealed with a passivation layer.

Abstract: A composition of matter having the following general formula ##STR1## wherein L represents 2-hydroxy isobutyric acid. This composition of matter is useful in improving the reaction efficiency or yield when bonding rhenium to a chelating ligand preferably a polydentate sulfur, selenium, phosphorous or nitrogen ligand. This provides a method to bond radioactive rhenium to various chelating ligands for a radiopharmaceutical. Further, this also provides a method to bond a radioactive rhenium to a protein such as a monoclonal antibody. This in turn provides a method to provide beta emitting radiation to cancer cells.

Abstract: A method and apparatus for reducing the intensity of the sound that accompanies a rapid decompression in a pressurized hydraulic system such as that of an injection molding machine. The apparatus includes a reduced area valve that interconnects the high pressure system with a low pressure system, with the valve connected with a tubular muffler so that high pressure fluid is initially released through the valve and into the muffler. The muffler includes a plurality of spaced apertures that face a rigid structural surface so that the high pressure fluid passing through the muffler issues from the several apertures and impinges on the rigid structure to dissipate the pressure shock accompanying decompression, and thereby modulate the intensity of the sound of decompression.

Abstract: A myocardial imaging agent for humans is a technetium(III) complex ligated in the planar positions by a tetradentate ligand such as (acac).sub.2 en and in the axial positions by an ether containing phosphine ligand such as tris(3-methoxy-1-propyl)phosphine. The agent exhibits extremely rapid blood clearance after injection into a human and has a sufficiently high heart/liver and heart/lung ratios to provide effective myocardial images.

Abstract: A base supports a workpiece form-holding means in either a stationary or rotatable manner. A cross-slide and corresponding fiber creel assembly which is affixed to, and depends from, the cross-slide assembly is carried with respect to the workpiece form-holding means by a hanging carriage carried on an overhead support beam. A fiber payout eye is carried on the cross-slide assembly for guiding fiber from the fiber creel assembly to the workpiece form as the carriage and cross-slide are moving.

Abstract: An improved computer controlled hydraulic system for a conventional toggle-operated plastic injection molding machine comprising an injection assembly and a mold clamping assembly. The hydraulic system includes a first low volume pump and a second high volume pump connected between a reservoir of hydraulic fluid and a pressure and flow control manifold. The output of the pressure and flow control manifold is connected to an injection control manifold, in turn conected to and operating the instrumentalities of the injection assembly. The output of the pressure and flow control manifold is also connected to a clamping control manifold, in turn connected to and operating the cylinder of the clamping assembly. An isolation manifold is connected between the pressure and flow control manifold and the clamping control manifold. A third low volume pump is connected between the reservoir and the isolation manifold. The isolation manifold is also connected to the reservoir.

Abstract: A method of detecting anti-neoplastics particularly adriamycin by shining visible light through a filter at the anti-neoplastic. The filter effectively removes light which is not in the absorption spectrum of the anti-neoplastic. Light which is reflected off of the anti-neoplastic as well as fluorescing light is then permitted to pass through a second filter and into a detector. The second filter is designed to filter out any light emitted by the light source and permit basically only light that is fluorescing from the anti-neoplastic. The light passing through the filter is then detected by a detector. In one embodiment, the second filter is a pair of glasses and the detector is the eye of an individual. The light source can be portable providing a hand held light source to quickly scan the environment. This is effective in detecting extremely dilute concentrations of adrimycin.

Abstract: An adjustable angle mount particularly useful for removably supporting a police radar detector horizontally to the inside of any of a variety of vehicle windshields of various inclination angles. The mount has a pair of planar members hinged together at a horizontal axis, one member being attachable to the windshield by two horizontally spaced suction cups and with a third windshield contact point. Below the axis is a bearing surface against which a cam pinned to the other member bears, under the weight of a receiver removably supported thereon, to limit the angle between said members and support the receiver horizontally. The cam is rotatable by a driver accessible lever formed integrally of the cam.

Abstract: A useful brain perfusion imaging agent comprises ##STR1## wherein R completes a four or five member ring. The agent is stable in vitro permitting its use up to six to eight hours after preparation.

Abstract: A machine and control are provided for effecting motion of a function element, such as an adhesive material dispensing gun, and controlling the operation of the function element by means of a control signal proportional to the velocity of a workpoint associated with the function element. The control produces a velocity signal representing the velocity of the workpoint, calculates the value of a control signal using the velocity signal and predetermined constant defining the constant of proportionality and zero velocity output and applies the control signal to a digital-to-analogue converter to produce an output signal for controlling the function element.