Abstract: Methods of producing biopolymer ladders and their use to obtain structural information about the biopolymer. The ladders are produced by setting up catalytic cleavage and terminating reactions at the end of biopolymer molecules. The terminating reactions terminate cleavage of a percentage of the biopolymer molecules at each round of cleavage.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
August 11, 1998
Assignees:
The Rockefeller University, Scripps Research Institute, Ciphergen Biosystems, Inc.
Inventors:
Brian T. Chait, Rong Wang, Stephen B. H. Kent, Steven M. Clark
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