Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.
Type:
Grant
Filed:
April 16, 2020
Date of Patent:
September 27, 2022
Assignee:
CIPLA USA, INC.
Inventors:
Raissa Trend, Michael Dappen, Christopher E. Henry, Adam Aaron Goldblum, James Bradley Aggen, Ricardo Filipe de Jesus Gonçalves Mendonça, João Carlos Falcão Sardinha
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
September 14, 2021
Assignee:
CIPLA USA, INC.
Inventors:
James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt