Patents Assigned to Circassia Limited
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Patent number: 10143991Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: GrantFiled: September 15, 2015Date of Patent: December 4, 2018Assignee: Circassia LimitedInventors: James Robinson, Graham Ruecroft
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Patent number: 9850281Abstract: Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and comprise: (I) the amino acid sequence: (a) GGYKAAVRPTMLE (SEQ ID NO: 35; Cla35), (b) AE V YQKLK SLTKK (SEQ ID NO: 31; Cla16), (c) VAITYASRAQGAE (SEQ ID NO: 32; Cla25), (d) GHHFKERGT-GSLVIT (SEQ ID NO: 33; Cla26), or (e) ANYTQTKTVSIRL (SEQ ID NO: 34; Cla29); or (II) a T cell epitope-containing variant sequence which is a said amino acid sequence (I) having up to six amino acid modifications, each of which is independently a deletion, substitution or insertion.Type: GrantFiled: May 30, 2013Date of Patent: December 26, 2017Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Pascal Hickey, Mark Larche
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Patent number: 9744222Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: October 17, 2016Date of Patent: August 29, 2017Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
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Patent number: 9657061Abstract: The present invention relates to a hydrochloride salt of a peptide consisting of the sequence of CPAVKRDVDLFLT (SEQ ID NO: 1) as well as its combinations with other peptides for immunosuppressive purposes.Type: GrantFiled: May 9, 2013Date of Patent: May 23, 2017Assignee: Circassia LimitedInventors: Paul Laidler, Imre Farkas
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Patent number: 9375470Abstract: The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.Type: GrantFiled: October 6, 2015Date of Patent: June 28, 2016Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler
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Patent number: 9347937Abstract: The present invention relates to compositions for preventing or treating allergy to ragweed by tolerization. The compositions are based on combinations of peptide fragments derived from the major allergen in ragweed pollen, Amb a 1. The invention also relates to products, vectors and formulations which may be used to provide polypeptides of the invention in combination. The invention further relates to in vitro methods for determining whether T cells recognize a polypeptide of the invention, and for determining whether an individual has or is at risk of a condition characterized by allergic symptoms in response to a ragweed allergen.Type: GrantFiled: June 14, 2013Date of Patent: May 24, 2016Assignee: Circassia LimitedInventors: Mark Larche, Roderick Peter Hafner, Paul Laidler
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Patent number: 9340580Abstract: The present invention relates to peptides comprising multiple MHC Class II-binding T cell epitopes for tolerization therapy.Type: GrantFiled: August 15, 2008Date of Patent: May 17, 2016Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Mark Larche
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Patent number: 9180098Abstract: The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.Type: GrantFiled: November 27, 2009Date of Patent: November 10, 2015Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler
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Patent number: 9168295Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.Type: GrantFiled: August 22, 2013Date of Patent: October 27, 2015Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Mark Larche, Anthony Barrington Kay
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Patent number: 9120865Abstract: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having Bermuda grass allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Bermuda grass pollen allergy. The molecules of the present invention are useful in the development of diagnostic, therapeutic and prophylactic agents for conditions characterized by an aberrant, inappropriate or otherwise unwanted immune response to Bermuda grass pollen or derivative or homolog thereof.Type: GrantFiled: August 30, 2010Date of Patent: September 1, 2015Assignee: Circassia LimitedInventors: Robyn O'Hehir, Jennifer Rolland
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Patent number: 9017689Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: February 15, 2011Date of Patent: April 28, 2015Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
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Patent number: 8821887Abstract: A first or second polypeptide for use in a method of treating or preventing a disorder by tolerization, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterized by an inappropriate immune response to the protein allergen from which the second polypeptide derives.Type: GrantFiled: August 14, 2009Date of Patent: September 2, 2014Assignee: Circassia LimitedInventors: Mark Larche, Roderick Peter Hafner, Paul Laidler
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Publication number: 20140186403Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: January 8, 2014Publication date: July 3, 2014Applicant: CIRCASSIA LIMITEDInventors: Roderick Peter HAFNER, Paul LAIDLER, Mark LARCHE
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Patent number: 8753644Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: February 5, 2010Date of Patent: June 17, 2014Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
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Publication number: 20140050750Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptidesType: ApplicationFiled: August 22, 2013Publication date: February 20, 2014Applicant: CIRCASSIA LIMITEDInventors: RODERICK PETER HAFNER, MARK LARCHE, ANTHONY BARRINGTON KAY
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Patent number: 8652485Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: August 15, 2008Date of Patent: February 18, 2014Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
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Publication number: 20130336999Abstract: The present invention relates to peptide which are formulated or engineered to prevent or reduce the formation of dimers.Type: ApplicationFiled: August 23, 2013Publication date: December 19, 2013Applicant: CIRCASSIA LIMITEDInventors: RODERICK PETER HAFNER, PAUL LAIDLER
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Patent number: 8551493Abstract: The present invention relates to peptides which are formulated or engineered to prevent or reduce the formation of dimers.Type: GrantFiled: August 15, 2008Date of Patent: October 8, 2013Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler
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Patent number: 8551492Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.Type: GrantFiled: May 30, 2008Date of Patent: October 8, 2013Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Mark Larche, Anthony Barrington Kay
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Publication number: 20130243798Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: February 15, 2011Publication date: September 19, 2013Applicant: CIRCASSIA LIMITEDInventors: Christopher Hugh Reginald Stocker, Paul Laidler, Mark Larche, Roderick Peter Hafner