Patents Assigned to Circassia Limited
  • Patent number: 10143991
    Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: December 4, 2018
    Assignee: Circassia Limited
    Inventors: James Robinson, Graham Ruecroft
  • Patent number: 9850281
    Abstract: Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and comprise: (I) the amino acid sequence: (a) GGYKAAVRPTMLE (SEQ ID NO: 35; Cla35), (b) AE V YQKLK SLTKK (SEQ ID NO: 31; Cla16), (c) VAITYASRAQGAE (SEQ ID NO: 32; Cla25), (d) GHHFKERGT-GSLVIT (SEQ ID NO: 33; Cla26), or (e) ANYTQTKTVSIRL (SEQ ID NO: 34; Cla29); or (II) a T cell epitope-containing variant sequence which is a said amino acid sequence (I) having up to six amino acid modifications, each of which is independently a deletion, substitution or insertion.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: December 26, 2017
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler, Pascal Hickey, Mark Larche
  • Patent number: 9744222
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: August 29, 2017
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
  • Patent number: 9657061
    Abstract: The present invention relates to a hydrochloride salt of a peptide consisting of the sequence of CPAVKRDVDLFLT (SEQ ID NO: 1) as well as its combinations with other peptides for immunosuppressive purposes.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: May 23, 2017
    Assignee: Circassia Limited
    Inventors: Paul Laidler, Imre Farkas
  • Patent number: 9375470
    Abstract: The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: June 28, 2016
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler
  • Patent number: 9347937
    Abstract: The present invention relates to compositions for preventing or treating allergy to ragweed by tolerization. The compositions are based on combinations of peptide fragments derived from the major allergen in ragweed pollen, Amb a 1. The invention also relates to products, vectors and formulations which may be used to provide polypeptides of the invention in combination. The invention further relates to in vitro methods for determining whether T cells recognize a polypeptide of the invention, and for determining whether an individual has or is at risk of a condition characterized by allergic symptoms in response to a ragweed allergen.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: May 24, 2016
    Assignee: Circassia Limited
    Inventors: Mark Larche, Roderick Peter Hafner, Paul Laidler
  • Patent number: 9340580
    Abstract: The present invention relates to peptides comprising multiple MHC Class II-binding T cell epitopes for tolerization therapy.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: May 17, 2016
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Mark Larche
  • Patent number: 9180098
    Abstract: The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: November 10, 2015
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler
  • Patent number: 9168295
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: October 27, 2015
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Mark Larche, Anthony Barrington Kay
  • Patent number: 9120865
    Abstract: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having Bermuda grass allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Bermuda grass pollen allergy. The molecules of the present invention are useful in the development of diagnostic, therapeutic and prophylactic agents for conditions characterized by an aberrant, inappropriate or otherwise unwanted immune response to Bermuda grass pollen or derivative or homolog thereof.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: September 1, 2015
    Assignee: Circassia Limited
    Inventors: Robyn O'Hehir, Jennifer Rolland
  • Patent number: 9017689
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: April 28, 2015
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
  • Patent number: 8821887
    Abstract: A first or second polypeptide for use in a method of treating or preventing a disorder by tolerization, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterized by an inappropriate immune response to the protein allergen from which the second polypeptide derives.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: September 2, 2014
    Assignee: Circassia Limited
    Inventors: Mark Larche, Roderick Peter Hafner, Paul Laidler
  • Publication number: 20140186403
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 3, 2014
    Applicant: CIRCASSIA LIMITED
    Inventors: Roderick Peter HAFNER, Paul LAIDLER, Mark LARCHE
  • Patent number: 8753644
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: June 17, 2014
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
  • Publication number: 20140050750
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides
    Type: Application
    Filed: August 22, 2013
    Publication date: February 20, 2014
    Applicant: CIRCASSIA LIMITED
    Inventors: RODERICK PETER HAFNER, MARK LARCHE, ANTHONY BARRINGTON KAY
  • Patent number: 8652485
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: February 18, 2014
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
  • Publication number: 20130336999
    Abstract: The present invention relates to peptide which are formulated or engineered to prevent or reduce the formation of dimers.
    Type: Application
    Filed: August 23, 2013
    Publication date: December 19, 2013
    Applicant: CIRCASSIA LIMITED
    Inventors: RODERICK PETER HAFNER, PAUL LAIDLER
  • Patent number: 8551493
    Abstract: The present invention relates to peptides which are formulated or engineered to prevent or reduce the formation of dimers.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: October 8, 2013
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Paul Laidler
  • Patent number: 8551492
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: October 8, 2013
    Assignee: Circassia Limited
    Inventors: Roderick Peter Hafner, Mark Larche, Anthony Barrington Kay
  • Publication number: 20130243798
    Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.
    Type: Application
    Filed: February 15, 2011
    Publication date: September 19, 2013
    Applicant: CIRCASSIA LIMITED
    Inventors: Christopher Hugh Reginald Stocker, Paul Laidler, Mark Larche, Roderick Peter Hafner