Patents Assigned to CIRCULOGENE THERANOSTICS, LLC
  • Method of preparing cell free nucleic acid molecules by in situ amplification
    Patent number: 11015213
    Abstract: Methods for in situ amplification (ISA) of cfNA, such as cfDNA, in a sample are provided wherein the cfNA in the sample is not subject to a nucleic acid purification step. The methods disclosed may be used to generate an analyzable pool of cfNA present in the sample. The analyzable pool may be used with a variety of analytical techniques to characterize the nucleic acid in the sample. Methods of diagnosis, determining a therapeutic intervention and monitoring of a subject are also provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 25, 2021
    Assignee: CIRCULOGENE THERANOSTICS, LLC
    Inventor: Chen-Hsiung Yeh