Patents Assigned to CISBIO BIOASSAYS
  • Patent number: 11993618
    Abstract: The invention relates to complexing agents of formula (I): wherein Chrom1, Chrom2 and Chrom3 are as defined in the description. The invention also relates to lanthanide complexes obtained from these complexing agents.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: May 28, 2024
    Assignee: CISBIO BIOASSAYS
    Inventors: Laurent Lamarque, Jurriaan Zwier, Emmanuel Bourrier
  • Publication number: 20230382928
    Abstract: The invention relates to a compound of formula (I) wherein R1; R2, R3 and R4 are as defined in the description. The invention also relates to europium (III) complexes obtained from a compound of formula (I), or from a complexing agent including said compound, and to the use of such complexes to label organic or biological molecules.
    Type: Application
    Filed: October 27, 2021
    Publication date: November 30, 2023
    Applicant: CISBIO BIOASSAYS
    Inventors: David PARKER, Jack FRADGLEY, Matthieu STARCK, Jurriaan ZWIER, Laurent LAMARQUE
  • Patent number: 10597409
    Abstract: The invention relates to complexing agents of formula (I) in which A1, A2, A3 and R1 are as defined in the description. The invention also relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: March 24, 2020
    Assignees: CISBIO BIOASSAYS, UNIVERSITE PAUL SABATIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Laurent Lamarque, Claude Picard, Chantal Galaup, Nadine Leygue, Jurriaan Zwier, Emmanuel Bourrier
  • Patent number: 10287360
    Abstract: The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: May 14, 2019
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale, Université d' Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), CISBIO Bioassays, Institut Jean Paoli & Irene Calmettes
    Inventors: Daniel Baty, Patrick Chames, Damien Nevoltris, Gérard Mathis
  • Patent number: 10174115
    Abstract: The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: January 8, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE MONTPELLIER, CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ PARIS-SUD
    Inventors: Daniel Baty, Jean-Philippe Pin, Patrick Chames, Damien Nevoltris, Philippe Rondard, Pauline Scholler, Gérard Mathis
  • Patent number: 9880176
    Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 30, 2018
    Assignee: CISBIO BIOASSAYS
    Inventors: Delphine Jaga, Hamed Mokrane, Stéphane Martinez, Michel Fink
  • Patent number: 9296762
    Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: March 29, 2016
    Assignees: CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Laurent Lamarque, Olivier Maury, David Parker, Jurriaan Zwier, James W. Walton, Adrien Bourdolle
  • Publication number: 20150361116
    Abstract: The invention relates to complexing agents of formula (I): in which A, chrom1, chrom2 and chrom3 are as defined in the description. The invention also relates to the lanthanide complexes obtained from these complexing agents.
    Type: Application
    Filed: January 16, 2014
    Publication date: December 17, 2015
    Applicant: CISBIO BIOASSAYS
    Inventors: Laurent LAMARQUE, David PARKER, Stephen J. BUTLER, Martina DELBIANCO
  • Publication number: 20150185150
    Abstract: The subject matter of the invention is a method for measuring the luminescence of a long-life fluorescent compound present in a measuring medium, said medium containing a biological sample, characterized in that it comprises the following steps: a) introduction of a long-life fluorescent compound into the measuring medium, b) introduction, into the measuring medium, of a fluorescent marking agent, the absorption spectrum of which allows the excitation thereof at the same wavelength as that used to excite the long-life fluorescent compound, wherein said emission spectrum allows the measurement of the luminescence thereof at the same wavelength as that used to measure the luminescence of the long-life fluorescent compound, c) excitation of the measuring medium with a wavelength corresponding to an absorption peak of the long-life fluorescent compound, d) measurement of the luminescence emitted by the measuring medium immediately after excitation of said medium, mainly corresponding to the luminescence of the
    Type: Application
    Filed: February 22, 2012
    Publication date: July 2, 2015
    Applicant: CISBIO BIOASSAYS
    Inventors: Gerard Mathis, Herve Bazin
  • Publication number: 20150024410
    Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 22, 2015
    Applicant: CISBIO BIOASSAYS
    Inventors: Delphine Jaga, Hamed Mokrane, Stéphane Martinez, Michel Fink
  • Publication number: 20140336373
    Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.
    Type: Application
    Filed: July 17, 2012
    Publication date: November 13, 2014
    Applicants: CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Laurent Lamarque, Olivier Maury, David Parker, Jurriaan Zwier, James W. Walton, Adrien Bourdolle
  • Publication number: 20140242611
    Abstract: The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.
    Type: Application
    Filed: July 4, 2012
    Publication date: August 28, 2014
    Applicant: CISBIO BIOASSAYS
    Inventors: Hervé Bazin, Gérard Mathis