Patents Assigned to CISBIO BIOASSAYS
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Patent number: 11993618Abstract: The invention relates to complexing agents of formula (I): wherein Chrom1, Chrom2 and Chrom3 are as defined in the description. The invention also relates to lanthanide complexes obtained from these complexing agents.Type: GrantFiled: June 11, 2018Date of Patent: May 28, 2024Assignee: CISBIO BIOASSAYSInventors: Laurent Lamarque, Jurriaan Zwier, Emmanuel Bourrier
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Publication number: 20230382928Abstract: The invention relates to a compound of formula (I) wherein R1; R2, R3 and R4 are as defined in the description. The invention also relates to europium (III) complexes obtained from a compound of formula (I), or from a complexing agent including said compound, and to the use of such complexes to label organic or biological molecules.Type: ApplicationFiled: October 27, 2021Publication date: November 30, 2023Applicant: CISBIO BIOASSAYSInventors: David PARKER, Jack FRADGLEY, Matthieu STARCK, Jurriaan ZWIER, Laurent LAMARQUE
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Patent number: 10597409Abstract: The invention relates to complexing agents of formula (I) in which A1, A2, A3 and R1 are as defined in the description. The invention also relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.Type: GrantFiled: December 9, 2016Date of Patent: March 24, 2020Assignees: CISBIO BIOASSAYS, UNIVERSITE PAUL SABATIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Laurent Lamarque, Claude Picard, Chantal Galaup, Nadine Leygue, Jurriaan Zwier, Emmanuel Bourrier
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Patent number: 10287360Abstract: The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.Type: GrantFiled: May 22, 2015Date of Patent: May 14, 2019Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale, Université d' Aix-Marseille, Centre National de la Recherche Scientifique (CNRS), CISBIO Bioassays, Institut Jean Paoli & Irene CalmettesInventors: Daniel Baty, Patrick Chames, Damien Nevoltris, Gérard Mathis
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Patent number: 10174115Abstract: The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.Type: GrantFiled: July 3, 2015Date of Patent: January 8, 2019Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, UNIVERSITE DE MONTPELLIER, CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ PARIS-SUDInventors: Daniel Baty, Jean-Philippe Pin, Patrick Chames, Damien Nevoltris, Philippe Rondard, Pauline Scholler, Gérard Mathis
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Patent number: 9880176Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.Type: GrantFiled: September 13, 2012Date of Patent: January 30, 2018Assignee: CISBIO BIOASSAYSInventors: Delphine Jaga, Hamed Mokrane, Stéphane Martinez, Michel Fink
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Patent number: 9296762Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.Type: GrantFiled: July 17, 2012Date of Patent: March 29, 2016Assignees: CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYONInventors: Laurent Lamarque, Olivier Maury, David Parker, Jurriaan Zwier, James W. Walton, Adrien Bourdolle
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Publication number: 20150361116Abstract: The invention relates to complexing agents of formula (I): in which A, chrom1, chrom2 and chrom3 are as defined in the description. The invention also relates to the lanthanide complexes obtained from these complexing agents.Type: ApplicationFiled: January 16, 2014Publication date: December 17, 2015Applicant: CISBIO BIOASSAYSInventors: Laurent LAMARQUE, David PARKER, Stephen J. BUTLER, Martina DELBIANCO
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Publication number: 20150185150Abstract: The subject matter of the invention is a method for measuring the luminescence of a long-life fluorescent compound present in a measuring medium, said medium containing a biological sample, characterized in that it comprises the following steps: a) introduction of a long-life fluorescent compound into the measuring medium, b) introduction, into the measuring medium, of a fluorescent marking agent, the absorption spectrum of which allows the excitation thereof at the same wavelength as that used to excite the long-life fluorescent compound, wherein said emission spectrum allows the measurement of the luminescence thereof at the same wavelength as that used to measure the luminescence of the long-life fluorescent compound, c) excitation of the measuring medium with a wavelength corresponding to an absorption peak of the long-life fluorescent compound, d) measurement of the luminescence emitted by the measuring medium immediately after excitation of said medium, mainly corresponding to the luminescence of theType: ApplicationFiled: February 22, 2012Publication date: July 2, 2015Applicant: CISBIO BIOASSAYSInventors: Gerard Mathis, Herve Bazin
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Publication number: 20150024410Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.Type: ApplicationFiled: September 13, 2012Publication date: January 22, 2015Applicant: CISBIO BIOASSAYSInventors: Delphine Jaga, Hamed Mokrane, Stéphane Martinez, Michel Fink
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Publication number: 20140336373Abstract: The present invention concerns complexing agents of formula (I) in which a, b, c, chrom1, chrom2, chrom3, R3, R4 and R5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesizing said agents.Type: ApplicationFiled: July 17, 2012Publication date: November 13, 2014Applicants: CISBIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYONInventors: Laurent Lamarque, Olivier Maury, David Parker, Jurriaan Zwier, James W. Walton, Adrien Bourdolle
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Publication number: 20140242611Abstract: The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.Type: ApplicationFiled: July 4, 2012Publication date: August 28, 2014Applicant: CISBIO BIOASSAYSInventors: Hervé Bazin, Gérard Mathis