Patents Assigned to CISCIO BIOASSAYS
  • Single-domain antibody binding to the G protein alpha
    Patent number: 12187793
    Abstract: The present invention relates to a single-domain antibody (sdAb) which binds to the G protein alpha, comprising an amino acid sequence consisting of 3 CDR regions (CDR1 to CDR3) and 4 hinge regions (FR1 to FR4) according to the following formula (I): FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4 (I) and advantageously having a dissociation constant (Kd), measured in FRET, of less than 100 nM.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: January 7, 2025
    Assignees: CISCIO BIOASSAYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Thomas Fabien Michel Roux, Elodie Julie Dupuis, Eric Jacques Christian Trinquet, Mélanie Da Silva, Camille S. Mailhac, Patrick J M Chames, Daniel Baty, Julien Jean-Marius Soule, Philippe Rondard, Jean-Philippe R. Pin