Abstract: A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.
Type:
Grant
Filed:
August 8, 2018
Date of Patent:
October 26, 2021
Assignees:
CALIFORNIA INSTITUTE OF TECHNOLOGY, CITY OF HOPE, A NON-PROFIT CHARITABLE ORGANIZATION
Inventors:
Haowen Ruan, Jacob Berlin, Tom Haber, Changhuei Yang