Abstract: The present disclosure relates to methods of collecting exosomes and microvesicles (EMV) from urine, isolating corresponding mRNA, and analyzing expression patterns in order to diagnose and treat various urothelial cancers. In particular, various expression patterns are analyzed through a unique diagnostic formula.

Abstract: Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles contained in patient urine samples. In some embodiments, the quantified RNA from urine vesicles is compared to a normal population and in some embodiments is compared to the patient to evaluate kidney function over time.

Abstract: Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles contained in patient urine samples.

Abstract: A large-sized pneumatic radial tire is disclosed. The tire comprises a tread including grooves, a belt composed of a plurality of rubberized layers each containing steel cords, and a carcass of a substantially radial construction. The tread includes two half regions divided with respect to a crown center, one a region in a direction of plysteer due to the tire construction and the ground contact reaction force acting on steel cords of at least one rubberized layer disposed near the tread, and the other being a region opposite to the direction of plysteer. A row of small holes are formed in an island part along its edge near the kicking-out side of the groove in the region opposite to the direction of plysteer.