Abstract: This invention is related to a bag for digital devices with self-lock high-pressure sealing device, including lock body and core. The lock body has a long cylinder with a long groove at one side. The width of the groove is smaller than that of the lock core. Both sides of the groove have slope inside. The lock core is located in the long cylinder. The lock core and lock body are fixed by a positioning mechanism making the two interact with a proper clearance which is smaller than the thickness of the bag for digital devices. The invention utilizes the interaction between the lock body and the lock core to clamp the opening of the bag for digital devices and make it sealed for effective waterproof.