Patents Assigned to CJ HealthCare Corporation
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Patent number: 11202783Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease or dyslipidemia comprising an aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: July 20, 2018Date of Patent: December 21, 2021Assignee: CJ Healthcare CorporationInventors: Hyungjin Jun, So Young Ki, Keunho Lee, Jin Woo Jung, Dong Hyun Kim, Chi Hye Park, Hyoung Rok Bak, Shin-Young Ryu, Ju Hyun Lee, Ho-Youl Lee, Won-Hyuk Jung, Dong Hyun Ko, Seungin Kim, Joonseok Byun, Jae Ho Yoo, Seunghee Ji
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Patent number: 10723775Abstract: The present invention relates to a method for purifying darbepoetin alfa by selectively separating only a structural isoform having a high content of sialic acid from a mixture of structural isoforms of darbepoetin alfa having various contents of sialic acid. Since the method of the present invention is a novel method for purifying darbepoetin alfa which can be conveniently and simply produced, it is possible to remarkably increase productivity due to process efficiency improvement, as well as to yield high purity darbepoetin alfa when mass-producing darbepoetin alfa according to the present invention.Type: GrantFiled: November 28, 2014Date of Patent: July 28, 2020Assignee: CJ Healthcare CorporationInventors: Yoon Jung Lee, Kyung Hwa Kim, Yoo Hee Yang, Jung Min Yoo, Se Jun Kim, Ji Hyun Moon, Hoo Keun Oh, Dong Eok Lee, Won Jeong Lee, Jung Rok Lee, Chung Min Lee, Eun Young Choi, Gyong Sik Ha
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Publication number: 20200146974Abstract: The present disclosure relates to a composition for injection, which comprises a pharmaceutically acceptable salt of a compound represented by Formula 1 and one or more selected from mannitol, trehalose, lactose and glucose as a stabilizing agent, having improved stability.Type: ApplicationFiled: July 6, 2018Publication date: May 14, 2020Applicant: CJ HEALTHCARE CORPORATIONInventors: Hyo Jin KIM, Sung Jun KIM, Min Kyoung LEE, Sung Ah LEE, Mi Young YOON
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Publication number: 20200147101Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating non-alcoholic fatty liver disease or dyslipidemia comprising an aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof as an active ingredient.Type: ApplicationFiled: July 20, 2018Publication date: May 14, 2020Applicant: CJ Healthcare CorporationInventors: Hyungjin Jun, So Young Ki, Keunho Lee, Jin Woo Jung, Dong Hyun Kim, Chi Hye Park, Hyoung Rok Bak, Shin-Young Ryu, Ju Hyun Lee, Ho-Youl Lee, Won-Hyuk Jung, Dong Hyun Ko, Seungin Kim, Joonseok Byun, Jae Ho Yoo, Seunghee Ji
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Publication number: 20200069652Abstract: The present invention relates to a use of benzimidazole derivative compounds for improvement and treatment of nocturnal acid breakthrough (NAB). The benzimidazole derivative compounds can more effectively prevent and treat gastric acid-related diseases by effectively improving and treating nocturnal nocturnal acid breakthrough symptoms.Type: ApplicationFiled: November 7, 2019Publication date: March 5, 2020Applicants: CJ HEALTHCARE CORPORATION, RaQualia Pharma Inc.Inventors: Ha Jin LEE, Bong Tae KIM, Hyun KIM, Ji Yeon NAM, Jie Eun PARK, Geun Seog SONG, Shin Young RYU, Shinichi KOIZUMI, Nobuyuki TAKAHASHI, Masaomi TAJIMI
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Patent number: 10512635Abstract: The present invention relates to a use of benzimidazole derivative compounds for improvement and treatment of nocturnal acid breakthrough (NAB). The benzimidazole derivative compounds can mere effectively prevent and treat gastric acid-related diseases by effectively improving and treating nocturnal nocturnal acid breakthrough symptoms.Type: GrantFiled: June 8, 2016Date of Patent: December 24, 2019Assignees: CJ Healthcare Corporation, RaQualia Pharma Inc.Inventors: Ha Jin Lee, Bong Tae Kim, Hyun Kim, Ji Yeon Nam, Jie Eun Park, Geun Seog Song, Shin Young Ryu, Shinichi Koizumi, Nobuyuki Takahashi, Masaomi Tajimi
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Patent number: 10195149Abstract: The present invention relates to a continuous process for preparing microspheres and microspheres prepared thereby, and in particular, a process for preparing microspheres comprising steps of injecting a first emulsion and a second emulsion at the same time to form microspheres instantaneously, applying high pressure to the microspheres formed, and injecting the microspheres into an agitator, wherein the steps can be carried out continuously, and microspheres prepared thereby. When microspheres are prepared using the method of the present invention, scale variables, which have been the biggest disadvantage in existing preparation methods of microspheres, can be significantly reduced, drug encapsulation efficiency can be improved, and small and uniform particles can be obtained.Type: GrantFiled: May 15, 2014Date of Patent: February 5, 2019Assignee: CJ HEALTHCARE CORPORATIONInventors: Yi Mi Kim, Sun Kyung Lim, Mi Ran Park, Young Joon Park, Seung Hee Baek, Hyun Woo Shin
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Publication number: 20180338954Abstract: The present invention relates to a use of benzimidazole derivative compounds for improvement and treatment of nocturnal acid breakthrough (NAB). The benzimidazole derivative compounds can mere effectively prevent and treat gastric acid-related diseases by effectively improving and treating nocturnal nocturnal acid breakthrough symptoms.Type: ApplicationFiled: June 8, 2016Publication date: November 29, 2018Applicants: CJ HEALTHCARE CORPORATION, RaQualia Pharma Inc.Inventors: Ha Jin LEE, Bong Tae KIM, Hyun KIM, Ji Yeon NAM, Jie Eun PARK, Geun Seog SONG, Shin Young RYU, Shinichi KOIZUMI, Nobuyuki TAKAHASHI, Masaomi TAJIMI
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Patent number: 10047041Abstract: The present invention relates to a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating diabetes comprising the same as an active ingredient.Type: GrantFiled: July 14, 2015Date of Patent: August 14, 2018Assignee: CJ HEALTHCARE CORPORATIONInventors: Jae Ho Yoo, Seung Chan Kim, Soo Yeon Jung, Hyoung Rok Bak, Young Mee Chung, Sung Jun Kim, Sook Kyung Park, Seog Beom Song, Shin-Young Ryu, Mi Young Yoon, Dong Hyun Ko, Sun Young Park, Chi Hye Park, Nak Hyun Choi
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Patent number: 9908870Abstract: The present invention relates to a novel crystalline form of a benzimidazole derivative and a preparation method thereof. The novel crystalline form according to the present invention is hardly changed chemically and/or physically under a long-term photo-stressed condition, has a low hygroscopicity, and has an extremely low static-electricity-inducing capability, thus being advantageous for formulation, and due to the excellent stability of the crystal form itself, it is very useful for long-term storage of the compound.Type: GrantFiled: November 18, 2015Date of Patent: March 6, 2018Assignee: CJ HEALTHCARE CORPORATIONInventors: Young Ju Kim, Eun Sun Kim, Ji Yun Lee, Hyuk Woo Lee, Jae Hong Kweon, Sung Ah Lee, Kwang Do Choi, Dong Hyun Ko, Seung Pyeong Heo
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Patent number: 9902753Abstract: The present invention relates to a long-acting human growth hormone NexP-hGH protein and its production method. More specifically, it relates to a specific isoform of long-acting human growth hormone NexP-hGH protein in which human growth hormone is fused with a highly glycosylated alpha-1 antitrypsin mutant whereby long-acting properties in vivo are increased.Type: GrantFiled: June 5, 2013Date of Patent: February 27, 2018Assignees: CJ HEALTHCARE CORPORATION, ALTEOGEN, INCInventors: Gil Bu Kang, Chung Min Lee, Jee Won Ahn, Dong Eok Lee, Chang Bong Jun, Won Jeong Lee, Sung Yoo Cho, Chi Hye Park, Ki Wan Kim, Yoon Jung Lee, Ji Hyun Moon, Hoo Keun Oh, Young Joon Park, Sang Hyun Lee, Hyoung Taek Lim, Soon Jae Park, Hye Shin Chung, Sang Mee Lee
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Patent number: 9890129Abstract: The present invention relates to a novel aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating constipation comprising the same as an active ingredient.Type: GrantFiled: August 28, 2015Date of Patent: February 13, 2018Assignee: CJ HEALTHCARE CORPORATIONInventors: Won-Hyuk Jung, Seung In Kim, Seung Hee Ji, Dong Hyun Ko, Seog Beom Song, Keun Ho Lee, Hyung Jin Jun, Dong Kyu Kim, Dong Hyun Kim
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Publication number: 20170304208Abstract: The present invention relates to a gastric-retention type sustained-release formulation of metformin as an insulin-independent diabetic agent, and a preparation method thereof. More specifically, the present invention relates to a gastric-retention type sustained-release formulation, which can effectively control drug release even with a small amount of a polymer by forming a sustained-release granulated material, which comprises granules containing metformin or a pharmaceutically acceptable salt thereof and a swellable polymer, and a water-insoluble coated on the surface of the granules; and also can allow a tablet containing the drug to swell rapidly at an early stage by formulating via mixing of a superdisintegrant, which is capable of controlling the speed of gelation forming hydrogels, with the granulated material; and a preparation method thereof.Type: ApplicationFiled: July 21, 2015Publication date: October 26, 2017Applicant: CJ HEALTHCARE CORPORATIONInventors: Jun Hong PARK, Ji Eun LEE, Yu Jeong KIM, Chun Seon LYU, Hyuk Seong SEO, Tack Oon OH, Eun Kyung JEON, Sung Kyun HAN
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Publication number: 20170283386Abstract: The present invention relates to a novel aminoalkylbenzothiazepine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating constipation comprising the same as an active ingredient.Type: ApplicationFiled: August 28, 2015Publication date: October 5, 2017Applicant: CJ Healthcare CorporationInventors: Won-Hyuk Jung, Seung In Kim, Seung Hee Ji, Dong Hyun Ko, Seog Beom Song, Keun Ho Lee, Hyung Jin Jun, Dong Kyu Kim, Dong Hyun Kim
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Publication number: 20170247320Abstract: The present invention relates to a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating diabetes comprising the same as an active ingredient.Type: ApplicationFiled: July 14, 2015Publication date: August 31, 2017Applicant: CJ Healthcare CorporationInventors: Jae Ho Yoo, Seung Chan Kim, Soo Yeon Jung, Hyoung Rok Bak, Young Mee Chung, Sung Jun Kim, Sook Kyung Park, Seog Beom Song, Shin-Young Ryu, Mi Young Yoon, Dong Hyun Ko, Sun Young Park, Chi Hye Park, Nak Hyun Choi
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Patent number: 9687482Abstract: The present invention relates to a solifenacin preparation containing solifenacin or a pharmaceutically acceptable salt thereof, an antioxidant, and a binder, which is manufactured via direct compression. Compared to the preparations manufactured via conventional wet granulation process, the preparation of the present invention can be manufactured by a simplified process such as direct compression, and has improved content uniformity, mixing degree, etc., even when the preparation is manufactured by high speed tableting.Type: GrantFiled: January 29, 2015Date of Patent: June 27, 2017Assignee: CJ HEALTHCARE CORPORATIONInventors: Young Hee Suh, Young Dae Cho, Chun Seon Lyu, Mi Young Yoon, Ha Yong Choi, Sung Kyun Han
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Patent number: 9629844Abstract: The present invention relates to a stabilized pemetrexed formulation, and more specifically, to a stabilized pemetrexed formulation comprising acetylcysteine as an antioxidant and sodium citrate as a buffering agent. Additionally, the present invention relates to a pemetrexed formulation filled in a sealed container, comprising pemetrexed or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the oxygen gas content within the headspace of the container is 3 v/v % or less.Type: GrantFiled: May 8, 2014Date of Patent: April 25, 2017Assignee: CJ HEALTHCARE CORPORATIONInventors: Myung Jin Shin, Hong Chul Jin, Young Joon Park, Nak Hyun Choi, Ha Yong Choi
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Patent number: 9539213Abstract: The present invention relates to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby, and more particularly, to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby capable of preventing a solvent in a polymer solution for a carrier from being rapidly diffused to the aqueous medium before formation of the microspheres to reduce porosity of the microspheres and reduce surface roughness of the microspheres in order to obtain microspheres having a sphere shape, and increasing an encapsulation ratio of a bioactive substance, by using a polymer having a sol-gel transition property as a surfactant included in an aqueous medium into which a primary emulsion is injected and gelating a secondary emulsion formed after injecting the primary emulsion using the sol-gel transition property of the polymer used as the surfactant.Type: GrantFiled: March 20, 2014Date of Patent: January 10, 2017Assignee: CJ HEALTHCARE CORPORATIONInventors: Yi Mi Kim, Young Joon Park, Seung Hee Baek, Sun Kyung Lim
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Publication number: 20160361278Abstract: The present invention relates to a combination formulation containing metformin for treating non-insulin-dependent diabetes and an HMG-CoA reductase inhibitor for treating dyslipidemia. The present invention provides a combination formulation and a method for preparing the combination formulation, wherein the combination formulation contains metformin and an HMG-CoA reductase inhibitor, and has effectively improved stability by blocking physical and chemical reactions between the active ingredients while securing the stable release of respective active ingredients.Type: ApplicationFiled: July 25, 2014Publication date: December 15, 2016Applicant: CJ HEALTHCARE CORPORATIONInventors: Kwi Man KANG, Young Joon PARK, Jun Hong PARK, Ji Eun LEE, Seok Kee YOON, Yu Jeong KIM, Tack Oon OH, Tae Keun CHO
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Patent number: 9493425Abstract: The present invention provides a method for preparing a compound with a benzimidazole structure with an excellent yield using a low-cost starting material, not requiring an additional separation process, or not using a dangerous reagent during the manufacturing process. Furthermore, the present invention also provides an intermediate and a final product produced by the preparing method.Type: GrantFiled: July 4, 2014Date of Patent: November 15, 2016Assignee: CJ HEALTHCARE CORPORATIONInventors: Jae Hong Kweon, Eun Sun Kim, Seog Beom Song, Sung Ah Lee, Ji Yun Lee, Kwang Do Choi, Young Joon Park