Patents Assigned to Claragen, Inc.
  • Patent number: 7122344
    Abstract: The present invention relates generally to the production of recombinant human uteroglobin (rhUG) for use as a therapeutic in the treatment of inflammation and fibrotic diseases. More particularly, the invention provides processes, including broadly the steps of bacterial expression and protein purification, for the scaled-up production of rhUG according to current Good Manufacturing Practices (cGMP). The invention further provides analytical assays for evaluating the relative strength of in vivo biological activity of rhUG produced via the scaled-up cGMP processes.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: October 17, 2006
    Assignee: Claragen, Inc.
    Inventors: Aprile L. Pilon, Richard W. Welch
  • Publication number: 20020173460
    Abstract: Method for treatment of inflammatory and fibrotic conditions in vivo using pure rhUG is disclosed. Method for treating or preventing inflammatory or fibrotic conditions characterized by a deficiency of endogenous fictional UG is also disclosed. Compositions containing pure rhUG, optionally also containing lung surfactant, and assay procedures for detection of UG-fibronectin complexes, are also provided.
    Type: Application
    Filed: May 21, 2001
    Publication date: November 21, 2002
    Applicant: Claragen, Inc.
    Inventors: Aprile L. Pilon, Anil B. Mukherjee, Zhongjian Zhang
  • Patent number: 6255281
    Abstract: Method for treatment of inflammatory and fibrotic conditions in vivo using pure rhUG is disclosed. Method for treating or preventing inflammatory or fibrotic conditions characterized by a deficiency of endogenous functional UG is also disclosed. Compositions containing pure rhUG, optionally also containing lung surfactant, and assay procedures for detection of UG-fibronectin complexes, are also provided.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: July 3, 2001
    Assignee: Claragen, Inc. and U.S. Government
    Inventors: Aprile L. Pilon, Anil B. Mukherjee, Zhongjian Zhang