Patents Assigned to Clarapath, Inc.
  • Patent number: 11169056
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: November 9, 2021
    Assignee: Clarapath, Inc.
    Inventors: Partha P. Mitra, Baris Yagci, Cong Zhang
  • Patent number: 10796781
    Abstract: Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 6, 2020
    Assignee: Clarapath, Inc.
    Inventor: Partha P. Mitra
  • Patent number: 10724929
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Grant
    Filed: May 6, 2017
    Date of Patent: July 28, 2020
    Assignee: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20200166434
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 28, 2020
    Applicant: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20200064232
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Applicant: Clarapath, Inc.
    Inventors: Partha P. Mitra, Alexander S. Tolpygo, Robert L. Kleinberg
  • Patent number: 10571368
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: February 25, 2020
    Assignee: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Patent number: 10473557
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 12, 2019
    Assignee: Clarapath, Inc.
    Inventors: Partha P. Mitra, Alexander S. Tolpygo, Robert L. Kleinberg
  • Patent number: 10446260
    Abstract: The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalog of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the cataloged three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 15, 2019
    Assignee: Clarapath, Inc.
    Inventor: Partha P. Mitra
  • Publication number: 20170328818
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Application
    Filed: May 6, 2017
    Publication date: November 16, 2017
    Applicant: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20170205317
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Application
    Filed: April 1, 2017
    Publication date: July 20, 2017
    Applicant: Clarapath, Inc.
    Inventors: CONG ZHANG, Mark Fasciano, Partha P. Mitra
  • Publication number: 20170003309
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Application
    Filed: June 10, 2016
    Publication date: January 5, 2017
    Applicant: Clarapath, Inc.
    Inventors: PARTHA P. MITRA, Alexander S. Tolpygo, Robert L. Kleinberg