Patents Assigned to Clariant LSM Italia S.p.A
  • Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
    Patent number: 6433177
    Abstract: It is here described a new process for the synthesis of (S)-N-tertbutyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide wherein the N-carboxy anhydride of formula is treated with tert-butylamine in an organic inert solvent, preferably toluene, at a temperature of between −80 and −30° C.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: August 13, 2002
    Assignee: Clariant LSM Italia S.P.A.
    Inventors: Pietro Bellani, Aldo Banfi
  • Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide
    Patent number: 6340760
    Abstract: A description is given here of a novel process for the synthesis of N-carboxyanhydride of formula VI by reacting (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid with triphosgene in dioxane; a description is also given of a process for the synthesis of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide by treating the N-carboxyanhydride VI so obtained with tert-butylamine.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: January 22, 2002
    Assignee: Clariant LSM Italia S.p.A
    Inventors: Pietro Bellani, Marco Frigerio