Patents Assigned to Clavis Pharma ASA
  • Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
    Patent number: 9428540
    Abstract: The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: August 30, 2016
    Assignee: CLAVIS PHARMA ASA
    Inventors: Finn Myhren, Marit Liland Sandvold, Ole Henrik Eriksen, Steinar Hagen
  • Parenteral formulations of elacytarabine derivatives
    Patent number: 8912162
    Abstract: The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 1-?-D-arabinofuranosylcytosine (cytarabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in treatment of cancer.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: December 16, 2014
    Assignee: Clavis Pharma ASA
    Inventors: Sayeh Ahrabi, Finn Myhren, Ole Henrik Eriksen
  • PARENTERAL FORMULATIONS OF ELACYTARABINE DERIVATIVES
    Publication number: 20130196941
    Abstract: The present invention relates to parenteral formulations for certain long chain saturated and monounsaturated fatty acid derivatives of 1-?-D-arabinofuranosylcytosine (cytarabine). In particular, the present invention relates to a parenteral pharmaceutical composition and a method of the preparation thereof, in order to accommodate therapeutically effective doses of the said derivatives ameliorating compliance in treatment of cancer.
    Type: Application
    Filed: July 1, 2011
    Publication date: August 1, 2013
    Applicant: CLAVIS PHARMA ASA
    Inventors: Sayeh Ahrabi, Finn Myhren, Ole Henrik Eriksen
  • Azacytidine analogues and uses thereof
    Patent number: 8399420
    Abstract: The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3—(CH2)n—(CH?CH—CH2)m—CH?CH—(CH2)k—; k is an integer from 0 to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: March 19, 2013
    Assignees: Mount Sanai School of Medicine, Clavis Pharma ASA
    Inventors: Lewis Silverman, James Holland, Marit Liland Sandvold, Finn Myhren, Ole Henrik Eriksen
  • Methods and Compositions for Treating or Ameliorating Cancer Using Gemcitabine-5'-Elaidate
    Publication number: 20130005678
    Abstract: This invention provides methods and compositions for treating or otherwise ameliorating cancer in a subject, along with methods and compositions for measuring the levels of nucleoside transporters in a tumor and correlating this level to a predicated efficacy of a given anti-cancer drug regime, and methods and compositions for treating patients with low levels of hENT1 expression in cancer cells using a lipophilic gemcitabine analog such as gemcitabine-5?-elaidate.
    Type: Application
    Filed: March 30, 2011
    Publication date: January 3, 2013
    Applicant: CLAVIS PHARMA ASA
    Inventors: Marit Liland Sandvold, Finn Myhren
  • FATTY ACID ESTERS OF GLUCOCORTICOIDS AS ANTI-INFLAMMATORY AND ANTI-CANCER AGENTS
    Publication number: 20100099654
    Abstract: The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.
    Type: Application
    Filed: March 13, 2008
    Publication date: April 22, 2010
    Applicant: CLAVIS PHARMA ASA
    Inventors: Myhren Finn, Marit Liland Sandvold, Ole Henrik Eriksen, Steinar Hagen