Abstract: A clean containment room construction (2) comprising a work room (4) having a floor (6), walls (8) and a ceiling (10), an isolation void (12) which surrounds the walls (8) and the ceiling (10) of the work room (4), air-circulating apparatus (14) for maintaining a circulation of air in the workroom (4) which is at a positive pressure with respect to atmospheric pressure, and air-circulating apparatus (16) for maintaining air in the isolation void (12) which is at a negative pressure with respect to atmospheric pressure.