Abstract: The present disclosure relates to devices, systems, and methods for using foam fractionation to remove non-polar waste molecules, including, but not limited to, sewage bacteria, environmental contaminants, and/or sediment/turbidity caused by dredging activities, from open-water aquatic environments. Some foam fractionation systems disclosed herein generally include a plurality of floating foam fractionation devices, each floating foam fractionation device including a floating body, a submerged hood coupled to the body, and at least one submerged air conduits for releasing bubbles into the surrounding water. Other foam fractionation systems disclosed herein generally include a submerged bubble generation device and a floating intake unit positioned remotely from the submerged bubble generation device.