Patents Assigned to Clear Solutions Biotech, Inc.
  • Sodium hyaluronate microspheres
    Publication number: 20040127459
    Abstract: The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing hyaluronic acid and a dihydrazide with a crosslinker in an aqueous solution, adding a solvent and an emulsifying agent to form an emulsion, and lowering the pH of the emulsion to allow intramolecular and intermolecular crosslinking to occur, are also disclosed. The invention also provides for pharmaceutical or cosmetic formulations based on the microspheres described herein, further containing one or more active or cosmetic agents, and methods of using such formulations.
    Type: Application
    Filed: August 26, 2003
    Publication date: July 1, 2004
    Applicant: Clear Solutions Biotech, Inc
    Inventors: Philip Dehayza, Cheng Lu
  • Gene encoding hyaluronan synthase
    Patent number: 6602693
    Abstract: An isolated and purified DNA molecule encoding hyaluronan synthase-2 (Has2) is provided, as is purified and isolated Has2 polypeptide. Also provided is an isolated and purified DNA molecule encoding hyaluronan synthase-3 (Has3), as is purified and isolated Has3 polypeptide.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: August 5, 2003
    Assignee: Clear Solutions Biotech, Inc.
    Inventors: John A. McDonald, Andrew P. Spicer, Mary Louise Augustine
  • Sodium hyaluronate microspheres
    Publication number: 20030096734
    Abstract: The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing hyaluronic acid and a dihydrazide with a crosslinker in an aqueous solution, adding a solvent and an emulsifying agent to form an emulsion, and lowering the pH of the emulsion to allow intramolecular and intermolecular crosslinking to occur, are also disclosed. The invention also provides for pharmaceutical or cosmetic formulations based on the microspheres described herein, further containing one or more active or cosmetic agents, and methods of using such formulations.
    Type: Application
    Filed: December 5, 2002
    Publication date: May 22, 2003
    Applicant: Clear Solutions Biotech, Inc.
    Inventors: Philip Dehazya, Cheng Lu