Patents Assigned to Clear Vascular, Inc.
  • Compositions of high specific activity Sn and methods of preparing the same
    Patent number: 8632748
    Abstract: Compositions of high specific activity 117mSn with specific activity of greater than 100 Ci/g Sn and methods of producing the same. The method includes exposing 116Cd to an ?-particle beam of sufficient incident kinetic energy and duration to convert a portion of the 116Cd to 117mSn to form an irradiated material. The irradiated material is dissolved to form an intermediate solution containing 117mSn and 116Cd. The 117mSn is separated from the 116Cd to yield high specific activity 117mSn.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: January 21, 2014
    Assignee: Clear Vascular, Inc.
    Inventors: Nigel Raymond Stevenson, Ian Martin Horn
  • COMPOSITIONS OF HIGH SPECIFIC ACTIVITY SN-117M AND METHODS OF PREPARING THE SAME
    Publication number: 20120321558
    Abstract: Compositions of high specific activity 117mSn with specific activity of greater than 100 Ci/g Sn and methods of producing the same. The method includes exposing 116Cd to an ?-particle beam of sufficient incident kinetic energy and duration to convert a portion of the 116Cd to 117mSn to form an irradiated material. The irradiated material is dissolved to form an intermediate solution containing 117mSn and 116Cd. The 117mSn is separated from the 116Cd to yield high specific activity 117mSn.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 20, 2012
    Applicant: CLEAR VASCULAR, INC.
    Inventors: Nigel Raymond Stevenson, Ian Martin Horn
  • METHODS AND COMPOSITIONS FOR TREATING LUMINAL INFLAMMATORY DISEASE
    Publication number: 20110077211
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Application
    Filed: December 8, 2010
    Publication date: March 31, 2011
    Applicant: Clear Vascular, Inc.
    Inventors: Gilbert R. Gonzales, Nicolas Chronos
  • Methods and compositions for treating luminal inflammatory disease
    Patent number: 7874975
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: January 25, 2011
    Assignee: Clear Vascular, Inc.
    Inventors: Gilbert R. Gonzales, Nicolas Chronos
  • COMPOSITIONS OF HIGH SPECIFIC ACTIVITY SN-117M AND METHODS OF PREPARING THE SAME
    Publication number: 20100166653
    Abstract: Compositions of high specific activity 117mSn with specific activity of greater than 100 Ci/g Sn and methods of producing the same. The method includes exposing 116Cd to an ?-particle beam of sufficient incident kinetic energy and duration to convert a portion of the 116Cd to 117mSn to form an irradiated material. The irradiated material is dissolved to form an intermediate solution containing 117mSn and 116Cd. The 117mSn is separated from the 116Cd to yield high specific activity 117mSn.
    Type: Application
    Filed: December 26, 2008
    Publication date: July 1, 2010
    Applicant: CLEAR VASCULAR, INC.
    Inventors: Nigel Raymond Stevenson, Ian Martin Horn
  • PEPTIDE AND MULTIVALENT PEPTIDE CONJUGATE FOR DIAGNOSIS AND TREATMENT OF VASCULAR PLAQUES
    Publication number: 20090191126
    Abstract: This invention encompasses compositions and methods for treating and imaging vulnerable plaque and other inflamed regions in a subject.
    Type: Application
    Filed: November 28, 2008
    Publication date: July 30, 2009
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CLEAR VASCULAR, INC.
    Inventors: Claude F. Meares, Mark R. McCoy, Jeffrey J. Day, Jinsheng Li
  • Methods and Therapies for Treating Inflammatory Conditions with Exposed Collagen
    Publication number: 20070071676
    Abstract: Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides to regions of exposed collagen in the vasculature or other body lumens. The conversion electron-emitting sources or other radionuclides are coupled to a collagen-binding substance and administered to the vasculature or other body lumen to permit binding for imaging and/or therapeutic purposes.
    Type: Application
    Filed: September 25, 2006
    Publication date: March 29, 2007
    Applicant: CLEAR VASCULAR, INC.
    Inventors: Gilbert Gonzales, Dale DeVore, Suresh Srivastava
  • Methods and compositions for treating luminal inflammatory disease
    Publication number: 20070021641
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Application
    Filed: July 5, 2006
    Publication date: January 25, 2007
    Applicant: Clear Vascular, Inc.
    Inventors: Gilbert Gonzales, Nicolas Chronos
  • Methods and apparatus for treatment of luminal hyperplasia
    Publication number: 20060235504
    Abstract: A luminal implant comprises a conversion electron emitting source present on an expandable scaffold. Implant may be positioned within a blood vessel or other luminal site at risk of hyperplasia or neoplasia. The conversion electrons emitted by the source will inhibit hyperplasia or neoplasia.
    Type: Application
    Filed: February 9, 2006
    Publication date: October 19, 2006
    Applicant: Clear Vascular, Inc.
    Inventor: Gilbert Gonzales