Patents Assigned to Clearside Biomedical, Inc.
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Patent number: 11944703Abstract: An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the suprachoroidal space (SCS). The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.Type: GrantFiled: August 3, 2023Date of Patent: April 2, 2024Assignee: Clearside Biomedical, Inc.Inventors: Ronald Yamamoto, Stanley R. Conston, David Sierra
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Publication number: 20230363941Abstract: Embodiments described herein relate to systems and methods of retinal injection. In some aspects, a method includes inserting a distal end portion of a hollow conduit of a medical injector into an eye of a patient until the distal end portion reaches a reference location, the medical injector having a housing from which the hollow conduit distally extends and confirming disposal of the distal end portion of the hollow conduit in the reference location. After the confirming, the method further includes extending the distal end portion of the hollow conduit distally relative to the housing and from the reference location such that the distal end portion enters an injection region of the eye. With the distal end portion of the hollow conduit disposed in the injection region of the eye, medicament is conveyed into the injection region via the hollow conduit.Type: ApplicationFiled: April 10, 2023Publication date: November 16, 2023Applicant: Clearside Biomedical, Inc.Inventors: Rafael Victor ANDINO, Chen-rei WAN, Clay G. PRICKETT, Jay HOPE, Jordan MYKLEBY, Nicolo GARBIN, Bradford A. RANGE, Justin D. HENRY
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Patent number: 11752101Abstract: An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the SCS. The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.Type: GrantFiled: April 1, 2022Date of Patent: September 12, 2023Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Ronald Yamamoto, Stanley R. Conston, David Sierra
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Publication number: 20230157869Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: January 19, 2023Publication date: May 25, 2023Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Patent number: 11596545Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.Type: GrantFiled: November 1, 2018Date of Patent: March 7, 2023Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor Andino, Thomas Edward Godfrey, Shelley Eckert Hancock, Samirkumar Patel, Keleigh Jo Mahn, Jesse Yoo, Vladimir Zarnitsyn
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Patent number: 11559428Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: July 12, 2019Date of Patent: January 24, 2023Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20220347014Abstract: An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the SCS. The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.Type: ApplicationFiled: April 1, 2022Publication date: November 3, 2022Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Ronald YAMAMOTO, Stanley R. CONSTON, David SIERRA
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Publication number: 20220062041Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.Type: ApplicationFiled: November 10, 2021Publication date: March 3, 2022Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Amy Lee HAMMACK, Stanley R. CONSTON, Ronald YAMAMOTO
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Publication number: 20210366311Abstract: Embodiments disclosed include fabrication and use of a three-dimensional, multi-compartmental anatomical model of a portion of an eye.Type: ApplicationFiled: May 24, 2021Publication date: November 25, 2021Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Nathan E. FISHER, Chen-rei WAN, Rafael Victor ANDINO
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Publication number: 20210220173Abstract: An apparatus includes a housing, an adjustment member, and a microneedle. The housing can be coupled to a medicament container, and includes a hub surface that can contact a target surface. The adjustment member is within the housing and separates an inner volume of the housing into a first chamber and a second chamber. The first chamber is fluidically coupled with the medicament container. The adjustment member, which is coupled to the microneedle, can transition between a first configuration and a second configuration. A proximal end portion of the microneedle is fluidically coupled to the first chamber such that a substance can be conveyed from the medicament container through the microneedle. A distal tip of the microneedle extends from the hub surface by a first distance when the adjustment member is in the first configuration, and by a second distance when the adjustment member is in the second configuration.Type: ApplicationFiled: April 6, 2021Publication date: July 22, 2021Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Shelley Eckert HANCOCK
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Publication number: 20210212940Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.Type: ApplicationFiled: March 30, 2021Publication date: July 15, 2021Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Ronald YAMAMOTO, Stanley R. CONSTON, David SIERRA
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Patent number: 10973681Abstract: An apparatus includes a housing, an adjustment member, and a microneedle. The housing can be coupled to a medicament container, and includes a hub surface that can contact a target surface. The adjustment member is within the housing and separates an inner volume of the housing into a first chamber and a second chamber. The first chamber is fluidically coupled with the medicament container. The adjustment member, which is coupled to the microneedle, can transition between a first configuration and a second configuration. A proximal end portion of the microneedle is fluidically coupled to the first chamber such that a substance can be conveyed from the medicament container through the microneedle. A distal tip of the microneedle extends from the hub surface by a first distance when the adjustment member is in the first configuration, and by a second distance when the adjustment member is in the second configuration.Type: GrantFiled: August 11, 2017Date of Patent: April 13, 2021Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael V. Andino, Shelley Eckert Hancock
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Patent number: 10952894Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.Type: GrantFiled: January 16, 2018Date of Patent: March 23, 2021Assignee: CLEARSIDE BIOMEDICAL, INC.Inventors: Amy Lee Hammack, Stanley R. Conston, Ronald Yamamoto
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Publication number: 20200390692Abstract: Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.Type: ApplicationFiled: January 13, 2020Publication date: December 17, 2020Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Ronald YAMAMOTO, Stanley R. CONSTON, David SIERRA
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Patent number: 10722396Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: October 2, 2019Date of Patent: July 28, 2020Assignee: CLEARSIDE BIOMEDICAL., INC.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Patent number: 10555833Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: April 6, 2018Date of Patent: February 11, 2020Assignee: Clearside Biomedical, Inc.Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20200030143Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: October 2, 2019Publication date: January 30, 2020Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Patent number: 10517756Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: GrantFiled: April 11, 2019Date of Patent: December 31, 2019Assignee: CLEARSIDE BIOMEDICAL, INCInventors: Rafael Victor Andino, Vladimir Zarnitsyn, Jesse Yoo, Christopher John Brooks, Trent John Kahute, Justin William Arsenault, David Jackson Trettin, Andrew Kent Bauer, Stephanie Elaine Lewis
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Publication number: 20190350755Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.Type: ApplicationFiled: July 12, 2019Publication date: November 21, 2019Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Vladimir ZARNITSYN, Jesse YOO, Christopher John BROOKS, Trent John KAHUTE, Justin William ARSENAULT, David Jackson TRETTIN, Andrew Kent BAUER, Stephanie Elaine LEWIS
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Publication number: 20190290485Abstract: Devices, methods, and kits for ocular drug delivery are described herein. In some embodiments, a method includes inserting a distal end portion of a puncture member into an eye to define a delivery passageway within the eye. The delivery passageway extends through ha sclera of the eye and a choroid of the eye. The delivery passageway is less than about 1.5 mm. The method further includes conveying a substance into a subretinal space within the eye via the distal end portion of the puncture member.Type: ApplicationFiled: June 13, 2019Publication date: September 26, 2019Applicant: CLEARSIDE BIOMEDICAL, INC.Inventors: Rafael Victor ANDINO, Thomas Edward GODFREY, Shelley Eckert HANCOCK, Samirkumar PATEL, Keleigh Jo STRUDTHOFF, Jesse YOO, Vladimir ZARNITSYN